دورية أكاديمية
Pediatric nephrology
| العنوان: | Pediatric nephrology |
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| المؤلفون: | van Stralen, Karlijn, Krischock, Leah, Schaefer, Franz, Verrina, Enrico, Groothoff, Jaap, Jager, Kitty, Tizard, Jane, Harambat, J., van Stralen, K.J., Espinosa, L., Groothoff, J.W., Hulton, S.A., Jankauskiene, A., Schaefer, F., Verrina, E., Jager, K.J., Cochat, P., Ruggiero, Barbara, Gianviti, Alessandra, Benetti, Elisa, Peruzzi, Licia, Barbano, Gian Carlo, Corona, Fabrizia, Ventura, Giovanna, Pecoraro, Carmine, Murer, Luisa, Ghiggeri, Gian Marco, Pennesi, Marco, Edefonti, Alberto, Coppo, Rosanna, Emma, Francesco, Bonthuis, Marjolein, van Stralen, Karlijn J., Jager, Kitty J., Musumeci, Antonino, Graziano, Ugo, Nuzzi, Francesca, Ferraiuolo, Salvatore, Severino, Giovanni, Malgieri, Gabriele, Minale, Bruno |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2011 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Friday 24 June 2011 |
| الوصف: | INTRODUCTION AND AIMS: Anaemia is a universal problem amongst children on peritoneal (PD) or hemodialysis (HD), due mainly to poor or complete lack of erythropoietin synthesis by the diseased kidneys, and an absolute and functional iron deficiency. The use of iron therapy and erythropoiesis stimulating agents (ESA) is recommended on dialysis to achieve optimal haemoglobin levels based on age. METHODS: To determine the prevalence and risk factors for anaemia in Europe we conducted several analyses on data from children registered in the ESPN/ERA-EDTA Registry, a large European registry collecting data on children in Europe on renal replacement therapy (RRT). Information on haemoglobin levels (hb) was available for a total of 2,147 children on dialysis between 1 month and 18 years of age, providing 5030 measurements from 17 countries. Analyses were performed using linear and logistic mixed model analyses and were adjusted for age, sex, cause of renal failure, duration and modality of RRT. Anaemia was defined using current guidelines according to age. RESULTS: Mean Hb level was 11.0 g/dl and 90.9% of the patients were on ESA. Of all patients, 9.3% had severely low Hb levels (<8.0 g/dl for those under 2 years, <8.5 g/dl for those ≥2), while 35.9% were mildly anaemic (8-10 g/dl and 8.5-11.0 resp.). Severly anaemic patients had lower median ferritin levels, and used less iron compared with those with higher Hb levels. Hb levels increased with age, were higher in PD compared with HD patients, and among those being on RRT for a longer period. There were no differences between males and females. Both very low and high ferritin levels were associated with lower Hb levels. Patients with congenital anomalies of the kidney and urinary tract (CAKUT) had the highest Hb levels, while the lowest were seen amongst those with metabolic disorders, specifically oxalosis (0.8 g/dl lower). Furthermore, patients with Finnish type nephropathy (FN) (0.4 g/dl lower) or a kidney tumour (1.7 g/dl lower) often requiring bilateral ... |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://ckj.oxfordjournals.org/cgi/content/short/4/suppl_2/4.s2.6Test; http://dx.doi.org/10.1093/ndtplus/4.s2.6Test |
| DOI: | 10.1093/ndtplus/4.s2.6 |
| الإتاحة: | https://doi.org/10.1093/ndtplus/4.s2.6Test http://ckj.oxfordjournals.org/cgi/content/short/4/suppl_2/4.s2.6Test |
| حقوق: | Copyright (C) 2011, European Renal Association - European Dialysis and Transplant Assoc |
| رقم الانضمام: | edsbas.273639D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndtplus/4.s2.6 |
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