Clinical evaluation of the recombinant 38 kDa protein of Mycobacterium tuberculosis
| العنوان: | Clinical evaluation of the recombinant 38 kDa protein of Mycobacterium tuberculosis |
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| المؤلفون: | Xiang-yu Huang, Shi-Ming Yan, Long-Feng Ma, Zhong-Yuan Wang, Xiuyun He, Feng-Zhi Luo, Zhuang Y, Jia Guo, Xiaogang Zhang, Yuan-Dong Liu, Yong-Ai Luo, Qing Wang, Ya-Jun Dong, Yan-jun Wang, Ji-Ping Zhang |
| المصدر: | Scandinavian Journal of Infectious Diseases. 40:121-126 |
| بيانات النشر: | Informa UK Limited, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Microbiology (medical), Tuberculosis, Lipoproteins, Guinea Pigs, Tuberculin, Sensitivity and Specificity, law.invention, Mycobacterium tuberculosis, Tuberculosis diagnosis, Antigen, law, Animals, Humans, Medicine, Antigens, Bacterial, General Immunology and Microbiology, biology, Tuberculin Test, business.industry, Significant difference, Nontuberculous Mycobacteria, General Medicine, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Mycobacterium bovis, Recombinant Proteins, Infectious Diseases, Immunology, Recombinant DNA, business, Clinical evaluation |
| الوصف: | The diagnosis of tuberculosis remains among public health concerns due to shortcomings of the purified protein derivative (PPD). Recombinant truncated 38 kDa protein (rTPA38) of Mycobacterium tuberculosis was evaluated to screen new tuberculosis-specific tuberculin. 539 patients, 1133 healthy controls, and 55 guinea pigs were recruited to assess their sensitivity and specificity to rTPA38; 221 healthy controls, with negative responses to rTPA38 and PPD, were vaccinated with M. bovis BCG to determine their cross-reactions with M. bovis BCG. The Mantoux technique was adopted to perform skin tests. No difference in the sensitivity of skin tests was detected between rTPA38 and PPD (78.2% vs 83.4%), but there was a significant difference in the specificity of skin tests between rTPA38 and PPD (75.2% vs 47.0%). Compared to PPD, rTPA38 elicited low positive responses for those recruitments vaccinated with M. bovis BCG. The rTPA38 had significant skin reactions in M. tuberculosis-sensitized guinea pigs, and the opposite was true for both M. fortuitum- and M. kansasii-sensitized guinea pigs. These findings indicate that rTPA38 may have potential as a tuberculosis-specific skin test antigen. |
| تدمد: | 1651-1980 0036-5548 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3f3665017a428dafbf926967dbc7e1Test https://doi.org/10.1080/00365540701596011Test |
| رقم الانضمام: | edsair.doi.dedup.....6a3f3665017a428dafbf926967dbc7e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16511980 00365548 |
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