المؤلفون: Shisha, Tamas, Posch, Maximilian G., Lehmann, Jeanette, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter

المساهمون: Novartis

المصدر: European Journal of Drug Metabolism and Pharmacokinetics ; volume 48, issue 5, page 553-566 ; ISSN 0378-7966 2107-0180

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الإتاحة: https://doi.org/10.1007/s13318-023-00847-3Test

المؤلفون: Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

المساهمون: Novartis

المصدر: Cell Reports Medicine ; volume 4, issue 5, page 101036 ; ISSN 2666-3791

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.xcrm.2023.101036Test
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/plainTest

المؤلفون: Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi

المصدر: ACS Medicinal Chemistry Letters; 8/10/2023, Vol. 14 Issue 8, p1054-1062, 9p

المؤلفون: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene, Zink, Florence

العلاقة: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene and Zink, Florence (2023) Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. ACS medicinal chemistry letters, 14 (8). pp. 1054-1062. ISSN 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test
https://oak.novartis.com/48414Test/
https://urldefense.com/v3/__https://pubs.acs.org/articlesonrequest/AOR-XMSQJCAESAJE7ANDBGJR__;!!N3hqHg43uw!uFA3uM4olcCL8tpKCJYXYyL3M18AlqJHvL11w9Hn1C8hAOd_Qr-Gh2R1bCZu3OuuUBvMawz8PHcn3D4u2P0BKWejMgTest$

المؤلفون: Shisha, Tamas, Posch, Maximilian G, Jeanette, Lehmann, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter

العلاقة: Shisha, Tamas, Posch, Maximilian G, Jeanette, Lehmann, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard and Gergely, Peter (2023) First-in-human study of safety, pharmacokinetics, and pharmacodynamics of MHV370, a dual inhibitor of Toll-like receptors 7 and 8, in healthy adults. European Journal of Drug Metabolism and Pharmacokinetics, 1 (1). pp. 1-14. ISSN 21070180

الإتاحة: https://doi.org/10.1007/s13318-023-00847-3Test
https://oak.novartis.com/49986Test/

المؤلفون: Velcicky, Juraj, Bodendorf, Ursula, Rigollier, Pascal, Epple, Robert, Beisner, Daniel R., Guerini, Danilo, Smith, Philip, Liu, Bo, Feifel, Roland, Wipfli, Peter, Aichholz, Reiner, Couttet, Philippe, Dix, Ina, Widmer, Toni, Wen, Ben, Brandl, Trixi

المصدر: Journal of Medicinal Chemistry ; volume 61, issue 3, page 865-880 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.7b01371Test

المؤلفون: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

العلاقة: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00696Test
https://oak.novartis.com/46530Test/

المؤلفون: Leist, Marcel, Uhlig, Stefan, Revesz, Laszlo, Feifel, Roland, Mackenzie, Andrew, Wendel, Albrecht, Künstle, Gerald

الوصول الحر: https://www.europeana.eu/item/2048441/item_WYFODBXERVWL7KYEYLGSPT2QA53YYHKA?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCaTest

المؤلفون: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia

العلاقة: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland and Betschart, Claudia (2020) Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists using a Biochemical TLR8 Antagonist Competition Assay. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c00130Test
https://oak.novartis.com/41810Test/

المؤلفون: Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri, Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra, Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel, Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas, Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ramage, Paul, Gerhartz, Bernd, Ostermeier, Daniela, Schubart Wellensiek, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen Klaus, Eder, Joerg, Sedrani, Richard, Harrison, Richard, Mogi, Muneto, Jaffee, Bruce, Adams, Christopher

العلاقة: Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri, Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra, Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel, Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas, Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ramage, Paul, Gerhartz, Bernd, Ostermeier, Daniela, Schubart Wellensiek, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen Klaus, Eder, Joerg, Sedrani, Richard, Harrison, Richard, Mogi, Muneto, Jaffee, Bruce and Adams, Christopher (2020) The discovery of 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid (LNP023), a Factor B inhibitor, specifically designed to be applicable to treating a diverse array of complement mediated diseases. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.9b01870Test
https://oak.novartis.com/41161Test/