دورية أكاديمية
Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke
| العنوان: | Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke |
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| المؤلفون: | Jaworek, Thomas, Xu, Huichun, Gaynor, Brady J., Cole, John W., Rannikmae, Kristiina, Stanne, Tara M., Tomppo, Liisa, Abedi, Vida, Amouyel, Philippe, Armstrong, Nicole D., Attia, John, Bell, Steven, Benavente, Oscar R., Boncoraglio, Giorgio B., Butterworth, Adam, Carcel-Marquez, Jara, Chen, Zhengming, Chong, Michael, Cruchaga, Carlos, Cushman, Mary, Danesh, John, Debette, Stephanie, Duggan, David J., Durda, Jon Peter, Engstrom, Gunnar, Enzinger, Chris, Faul, Jessica D., Fecteau, Natalie S., Fernandez-Cadenas, Israel, Gieger, Christian, Giese, Anne-Katrin, Grewal, Raji P., Grittner, Ulrike, Havulinna, Aki S., Heitsch, Laura, Hochberg, Marc C., Holliday, Elizabeth, Hu, Jie, Ilinca, Andreea, Irvin, Marguerite R., Jackson, Rebecca D., Jacob, Mina A., Janssen, Raquel Rabionet, Jimenez-Conde, Jordi, Johnson, Julie A., Kamatani, Yoichiro, Kardia, Sharon L., Koido, Masaru, Kubo, Michiaki, Lange, Leslie, Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher R., Li, Jiang, Li, Liming, Lin, Kuang, Lopez, Haley, Luke, Sothear, Maguire, Jane, Mcardle, Patrick F., Mcdonough, Caitrin W., Meschia, James F., Metso, Tiina, Muller-Nurasyid, Martina, O'Connor, Timothy D., O'Donnell, Martin, Peddareddygari, Leema R., Pera, Joanna, Perry, James A., Peters, Annette, Putaala, Jukka, Ray, Debashree, Rexrode, Kathryn, Ribases, Marta, Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Ryan, Kathleen A., Sacco, Ralph L., Salomaa, Veikko, Sanchez-Mora, Cristina, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Smith, Jennifer A., Smith, Nicholas L., Wassertheil-Smoller, Sylvia, Soederholm, Martin, Stine, O. C., Strbian, Daniel, Sudlow, Cathie L., Tatlisumak, Turgut, Terao, Chikashi, Thijs, Vincent, Torres-Aguila, Nuria P., Tregouet, David-Alexandre, Tuladhar, Anil M., Veldink, Jan H., Walters, Robin G., Weir, David R., Woo, Daniel, Worrall, Bradford B., Hong, Charles C., Ross, Owen, Zand, Ramin, Leeuw, Frank-Erik De, Lindgren, Arne G., Pare, Guillaume, Anderson, Christopher D., Markus, Hugh S., Jern, Christina, Malik, Rainer, Dichgans, Martin, Mitchell, Braxton D., Kittner, Steven J., Arly Onset Stroke Genetics Consortium of The International Stroke Genetics, Consortium |
| المساهمون: | Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0028-3878. |
| بيانات النشر: | HAL CCSD American Academy of Neurology |
| سنة النشر: | 2022 |
| المجموعة: | LillOA (HAL Lille Open Archive, Université de Lille) |
| مصطلحات موضوعية: | Infarction, Association studies in genetics, Stroke in young adults, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; BACKGROUND AND OBJECTIVES: Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke. METHODS: We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level data or summary statistics in 16,730 cases and 599,237 non-stroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late onset stroke (LOS) and compared polygenic risk scores for venous thromboembolism between EOS and LOS. RESULTS: We observed genome-wide significant associations of EOS with two variants in ABO, a known stroke locus. These variants tag blood subgroups O1 and A1, and the effect sizes of both variants were significantly larger in EOS compared to LOS. The odds ratio (OR) for rs529565, tagging O1, 0.88 (95% CI: 0.85-0.91) in EOS vs 0.96 (95% CI: 0.92-1.00) in LOS, and the OR for rs635634, tagging A1, was 1.16 (1.11-1.21) for EOS vs 1.05 (0.99-1.11) in LOS; p-values for interaction = 0.001 and 0.005, respectively. Using polygenic risk scores, we observed that greater genetic risk for venous thromboembolism, another prothrombotic condition, was more strongly associated with EOS compared to LOS (p=0.008). DISCUSSION: The ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03877027; https://hal.science/hal-03877027Test; https://hal.science/hal-03877027/documentTest; https://hal.science/hal-03877027/file/BPH_Neurology_2022_Jaworek.pdfTest |
| DOI: | 10.1212/wnl.0000000000201006 |
| الإتاحة: | https://doi.org/10.1212/wnl.0000000000201006Test https://hal.science/hal-03877027Test https://hal.science/hal-03877027/documentTest https://hal.science/hal-03877027/file/BPH_Neurology_2022_Jaworek.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E2B214F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1212/wnl.0000000000201006 |
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