المؤلفون: Chamberlain, James M, Kapur, Jaideep, Shinnar, Shlomo, Elm, Jordan, Holsti, Maija, Babcock, Lynn, Rogers, Alex, Barsan, William, Cloyd, James, Lowenstein, Daniel, Bleck, Thomas P, Conwit, Robin, Meinzer, Caitlyn, Cock, Hannah, Fountain, Nathan B, Underwood, Ellen, Connor, Jason T, Silbergleit, Robert, Gray, Emily, Gunter, Sonya, Fansler, Amy, Stevenson, Valerie, Bengelink, Erin, Harney, Deneil, Speers, Mickie, Black, Joy, Fisher, Natalie, Harsh, Donna, Ramakrishnan, Arthi, Harris, Lindsey, Bozeman, Nia, Spiteri, Aimee, Palesch, Yuko, Tillman, Holly, Zhao, Wenle, Pauls, Qi, Arnaud, Chris, Dillon, Catherine R, Riley, Jodie, Alford, Teldon, Conner, Cassidy, Coles, Lisa, Sathe, Abhi, Janis, Scott, Hartman, Adam, Fureman, Brandy, Trinka, Eugen, Treiman, David, Wright, David, Ratcliff, Jonathan, Hall, Alex, Williams, Alaina, Simon, Harold, Stanley, Nicholas, Humphries, Roger, Mims, Theresa, Short, Joann, Jones, Elizabeth, Ottman, Misty, Gentile, Nina, Isenberg, Derek, Reimer, Hannah, Kalugdan, Vernon Sayoc, Hemphill, Claude, Madhok, Debbie Yi, Duncan, Jeany, Randazzo, Dominica, Quinn, James, Visweswaran, Anita, Mann, Rosen, Adeoye, Opeolu, McMullan, Jason, Foreman, Brandon, Keegan, Sara, Biros, Michelle, Driver, Brian, Hendrickson, Audrey, Stang, Jamie, Lewandowski, Christopher, Miller, Joseph, Chaudhry, Kaleem, Berry, Shannen, Warden, Craig, Blake, Rachel, Cook, Jennifer NB, Sabolick, Erin, Selman, Antoine, Kissman, Katrina, Moore, Monica, Huff, J Stephen, Becker, Lea, Claassen, Jan, Velazquez, Angela, Falo, Cristina, Coralic, Zlatan, Grupp-Phelan, Jackie, Baren, Jill, Ellison, Angela, Woodford, Ashley, Samba, Ima

المصدر: The Lancet. 395(10231)

مصطلحات موضوعية: Neurodegenerative, Epilepsy, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Neurosciences, Pediatric, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Anticonvulsants, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Infant, Levetiracetam, Male, Middle Aged, Phenytoin, Status Epilepticus, Valproic Acid, Young Adult, Neurological Emergencies Treatment Trials, Pediatric Emergency Care Applied Research Network investigators, Medical and Health Sciences, General & Internal Medicine

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0sq0j2t3Test

المؤلفون: Johnston, Karen C., Bruno, Askiel, Pauls, Qi, Hall, Christiana E., Barrett, Kevin M., Barsan, William, Fansler, Amy, Van de Bruinhorst, Katrina, Janis, Scott, Durkalski-Mauldin, Valerie L.

المصدر: JAMA ; volume 322, issue 4, page 326 ; ISSN 0098-7484

الإتاحة: https://doi.org/10.1001/jama.2019.9346Test
https://jamanetwork.com/journals/jama/articlepdf/2738553/jama_johnston_2019_oi_190072.pdfTest

المؤلفون: Johnston, Karen C, Bruno, Askiel, Pauls, Qi, Hall, Christiana E, Barrett, Kevin M, Barsan, William, Fansler, Amy, Van de Bruinhorst, Katrina, Janis, Scott, Durkalski-Mauldin, Valerie L, Varade, Preet, MD

المصدر: Department of Medicine

مصطلحات موضوعية: Aged, Brain Ischemia, Female, Fibrinolytic Agents, Humans, Hyperglycemia, Hypoglycemia, Hypoglycemic Agents, Infusions, Intravenous, Injections, Subcutaneous, Insulin, Male, Middle Aged, Stroke, Tissue Plasminogen Activator, Treatment Outcome, Department of Medicine, Medicine and Health Sciences

العلاقة: https://scholarlyworks.lvhn.org/medicine/6235Test; https://pubmed.ncbi.nlm.nih.gov/31334795Test/

الإتاحة: https://scholarlyworks.lvhn.org/medicine/6235Test
https://pubmed.ncbi.nlm.nih.gov/31334795Test/

المؤلفون: Meurer, William J, Fansler, Amy, Jennings, Kathleen, Lyman, Jason, Barsan, William G, Johnston, Karen

المصدر: Stroke ; volume 46, issue suppl_1 ; ISSN 0039-2499 1524-4628

الإتاحة: https://doi.org/10.1161/str.46.suppl_1.55Test

المؤلفون: Bruno, Askiel, Durkalski, Valerie L., Hall, Christiana E., Juneja, Rattan, Barsan, William G., Janis, Scott, Meurer, William J., Fansler, Amy, Johnston, Karen C.

مصطلحات موضوعية: Protocols, Hyperglycemia, Clinical Trial, Cerebral Infarction, Acute Ischemic Stroke, Neurosciences, Health Sciences

وصف الملف: application/pdf

العلاقة: Bruno, Askiel; Durkalski, Valerie L.; Hall, Christiana E.; Juneja, Rattan; Barsan, William G.; Janis, Scott; Meurer, William J.; Fansler, Amy; Johnston, Karen C. (2014). "The S troke H yperglycemia I nsulin N etwork E ffort ( SHINE ) trial protocol: a randomized, blinded, efficacy trial of standard vs. intensive hyperglycemia management in acute stroke." International Journal of Stroke (2): 246-251.; https://hdl.handle.net/2027.42/102726Test; International Journal of Stroke; Wong AA, Schluter PJ, Henderson RD, O'Sullivan JD, Read SJ. Natural history of blood glucose within the first 48 hours after ischemic stroke. Neurology 2008; 70: 1036 – 1041.; de Courten‐Myers GM, Kleinholz M, Wagner KR, Myers RE. Normoglycemia (not hypoglycemia) optimizes outcome from middle cerebral artery occlusion. J Cereb Blood Flow Metab 1994; 14: 227 – 236.; Meden P, Andersen M, Overgaard K, Rasmussen RS, Boysen G. The effects of early insulin treatment combined with thrombolysis in rat embolic stroke. Neurol Res 2002; 24: 399 – 404.; Zhu CZ, Auer RN. Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia. J Neurosurg 2004; 101: 664 – 668.; Ntaios G, Egli M, Faouzi M, Michel P. J‐shaped association between serum glucose and functional outcome in acute ischemic stroke. Stroke 2010; 41: 2366 – 2370.; Malmberg K, Ryden L, Efendic S et al. Randomized trial of insulin‐glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995; 26: 57 – 65.; Van den Berghe G, Wilmer A, Hermans G et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354: 449 – 461.; Bruno A, Kent TA, Coull BM et al. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke 2008; 39: 384 – 389.; Johnston KC, Hall CE, Kissela BM, Bleck TP, Conaway MR. Glucose regulation in acute stroke patients (GRASP) trial: a randomized pilot trial. Stroke 2009; 40: 3804 – 3809.; Adams HP Jr, del Zoppo G, Alberts MJ et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007; 38: 1655 – 1711.; Gray CS, Hildreth AJ, Sandercock PA et al. Glucose‐potassium‐insulin infusions in the management of post‐stroke hyperglycaemia: the UK glucose insulin in stroke trial (GIST‐UK). Lancet Neurol 2007; 6: 397 – 406.; Kreisel SH, Berschin UM, Hammes HP et al. Pragmatic management of hyperglycaemia in acute ischaemic stroke: safety and feasibility of intensive intravenous insulin treatment. Cerebrovasc Dis 2009; 27: 167 – 175.; Walters MR, Weir CJ, Lees KR. A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients. Cerebrovasc Dis 2006; 22: 116 – 122.; Adams HP, Jr, Leclerc JR, Bluhmki E, Clarke W, Hansen MD, Hacke W. Measuring outcomes as a function of baseline severity of ischemic stroke. Cerebrovasc Dis 2004; 18: 124 – 129.; Adams HP, Jr, Effron MB, Torner J et al. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: abciximab in emergency treatment of stroke trial (AbESTT‐II). Stroke 2008; 39: 87 – 99.; Bruno A, Waddell MJ, Potter DJ et al. Opportunity to lower hyperglycaemia faster in patients with acute ischaemic stroke and diabetes. Int J Stroke 2010; 5: 338 – 339.; Zhao W, Hill MD, Palesch Y. Minimal sufficient balance – a new strategy to balance baseline covariates and preserve randomness of treatment allocation. Stat Methods Med Res 2012, doi:10.1177/0962280212436447.; Hu F, Rosenberger WF. The Theory of Response Adaptive Randomization in Clinical Trials. New York, Wiley, 2006.; Juneja R, Roudebush C, Kumar N et al. Utilization of a computerized intravenous insulin infusion program to control blood glucose in the intensive care unit. Diabetes Technol Ther 2007; 9: 232 – 240.; Towler DA, Havlin CE, Craft S, Cryer P. Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 1993; 42: 1791 – 1798.; Williams LS, Weinberger M, Harris LE, Biller J. Measuring quality of life in a way that is meaningful to stroke patients. Neurology 1999; 53: 1839 – 1843.; The National Institute of Neurological Disorders and Stroke rt‐PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581 – 1587.; Palesch YY, Hill MD, Ryckborst KJ, Tamariz D, Ginsberg MD. The ALIAS pilot trial: a dose‐escalation and safety study of albumin therapy for acute ischemic stroke – II: neurologic outcome and efficacy analysis. Stroke 2006; 37: 2107 – 2114.; Gould AL, Shih WJ. Modifying the design of ongoing trials without unblinding. Stat Med 1998; 17: 89 – 100.; O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979; 35: 549 – 556.; Lan KKG, Demets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983; 70: 659 – 663.; Gentile NT, Seftchick MW, Huynh T, Kruus LK, Gaughan J. Decreased mortality by normalizing blood glucose after acute ischemic stroke. Acad Emerg Med 2006; 13: 174 – 180.; Williams LS, Rotich J, Qi R et al. 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الإتاحة: https://doi.org/10.1111/ijs.12045Test
https://doi.org/10.1177/0962280212436447Test
https://hdl.handle.net/2027.42/102726Test

المؤلفون: Bruno, Askiel, Durkalski, Valerie L., Hall, Christiana E., Juneja, Rattan, Barsan, William G., Janis, Scott, Meurer, William J., Fansler, Amy, Johnston, Karen C., SHINE investigators

المساهمون: Department of Medicine, IU School of Medicine

المصدر: PMC

مصطلحات موضوعية: Hyperglycemia, etiology, Therapy, Hypoglycemic Agents, therapeutic use, Insulin, Stroke, Complications

وصف الملف: application/pdf

العلاقة: International Journal of Stroke: Official Journal of the International Stroke Society; Bruno, A., Durkalski, V. L., Hall, C. E., Juneja, R., Barsan, W. G., Janis, S., … Johnston, K. C. (2014). The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial protocol; a randomized, blinded, efficacy trial of standard versus intensive hyperglycemia treatment in acute stroke. International Journal of Stroke : Official Journal of the International Stroke Society, 9(2), 246–251. http://doi.org/10.1111/ijs.12045Test; https://hdl.handle.net/1805/9264Test

الإتاحة: https://doi.org/10.1111/ijs.12045Test
https://hdl.handle.net/1805/9264Test

المؤلفون: Bruno, Askiel, Durkalski, Valerie L., Hall, Christiana E., Juneja, Rattan, Barsan, William G., Janis, Scott, Meurer, William J., Fansler, Amy, Johnston, Karen C.

المصدر: International Journal of Stroke ; volume 9, issue 2, page 246-251 ; ISSN 1747-4930 1747-4949

الإتاحة: https://doi.org/10.1111/ijs.12045Test

المؤلفون: Fabbri, Stefani, Farrell, Leah, Plageman, Kendall, Johnston, Robert, Penberthy, Jennifer K., Ceperich, Sherry E., Hettema, Jennifer E., Fansler, Amy, Ingersoll, Karen S.

المصدر: PsycEXTRA Dataset

الإتاحة: https://doi.org/10.1037/e634922009-001Test

المؤلفون: Ingersoll, Karen S., Ceperich, Sherry R. D., Farrell, Leah V., Detrick, Corey, Marzani-Nissen, Gabrielle, Fansler, Amy C., Cohen, Jessye X.

المصدر: PsycEXTRA Dataset

الإتاحة: https://doi.org/10.1037/e516242008-001Test

المؤلفون: Ingersoll, Karen S., Wagner, Christopher C., Ceperich, Sherry R. D., Von Sternberg, Kirk, Sobell, Linda C., Velasquez, Mary M., Sobell, Mark B., Fansler, Amy C., Agrawal, Sangeeta

المصدر: PsycEXTRA Dataset

الإتاحة: https://doi.org/10.1037/e518862008-001Test