Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels
| العنوان: | Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels |
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| المؤلفون: | Yu Zhao, Fa-Xian Ding, Ping Cao, Jing Wang, Li-Li Zhang, Yuan-Yuan Qi |
| المصدر: | Renal Failure |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, China, medicine.medical_specialty, Single-nucleotide polymorphism, Critical Care and Intensive Care Medicine, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, secondary hyperparathyroidism, single nucleotide polymorphism, Chronic kidney disease, Internal medicine, Genotype, Odds Ratio, Humans, Medicine, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, Promoter Regions, Genetic, Genotyping, business.industry, peptidyl-prolyl cis/trans isomerase NIMA-interacting 1, Promoter, General Medicine, Odds ratio, Middle Aged, medicine.disease, NIMA-Interacting Peptidylprolyl Isomerase, Logistic Models, 030104 developmental biology, Endocrinology, Nephrology, 030220 oncology & carcinogenesis, Multivariate Analysis, Clinical Study, Female, Hyperparathyroidism, Secondary, Secondary hyperparathyroidism, Restriction fragment length polymorphism, business, Kidney disease |
| الوصف: | Background: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is a key regulator of PTH mRNA stability. Secondary hyperparathyroidism (SHPT), which is characterized by elevated serum PTH levels, is a common complication of CKD. We investigated the possible associations between CKD with SHPT (CKD SHPT) and single-nucleotide polymorphisms of the Pin1 gene and compared the levels of the Pin1 protein in the CKD SHPT patients with those of the controls. Methods: The study group included 251 CKD SHPT patients and 61 controls. One putative functional SNP (single nucleotide polymorphism) in the Pin1 promoter (rs2233679C > T: c.−667C > T) is the main object. Genotyping was performed on purified DNA using polymerase chain reaction-restriction (PCR) and restriction fragment length polymorphisms (RFLP). The levels of Pin1 were measured in serum using an enzyme-linked immunosorbent assay. Results: Genotyping showed that CT + TT in the Pin1 promoter was significantly more common in the CKD SHPT group than in the control group (p |
| تدمد: | 1525-6049 0886-022X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0a6860c05d1adfdc5668f5f885c744Test https://doi.org/10.1080/0886022x.2016.1256310Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d0a6860c05d1adfdc5668f5f885c744 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15256049 0886022X |
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