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المؤلفون: Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fcTest
http://www.sciencedirect.com/science/article/pii/S2352345X21000862Test -
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المؤلفون: Maria Almira Correia, Sung-Mi Kim, Doyoung Kwon
المصدر: Acta Pharmaceutica Sinica. B
Acta pharmaceutica Sinica. B, vol 10, iss 1
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 42-60 (2020)مصطلحات موضوعية: Il-6, IRS1, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, stearoyl-coenzyme A desaturase, Review, Insig1, insulin-induced gene 1, gp78/AMFR, 0302 clinical medicine, Endoplasmic reticulum- associated degradation, Il-6, interleukin 6, ATF2, activator protein 1, General Pharmacology, Toxicology and Pharmaceutics, Non-alcoholic steatohepatitis, shRNAi, shRNA interference, Mcp1, chemokine (C–C motif) ligand 1, 0303 health sciences, CHIP, Pgc1, peroxisome proliferator-activated receptor coactivator 1, Liver Disease, Il-1β, AMPK1, ATPases associated with various cellular activities, acetylcholinesterase, autophagy-related 14, 3. Good health, Cell biology, glyceraldehyde 3-phosphate dehydrogenase, carbamazepine, 030220 oncology & carcinogenesis, Fas, fatty acid synthase, ACOX1, activating transcription factor 2, INH, Cytochromes P450, UPD, ubiquitin (Ub)-dependent proteasomal degradation, AMPKI, lipoprotein lipase, Endoplasmic-reticulum-associated protein degradation, insulin-induced gene 1, 03 medical and health sciences, CBZ, ubiquitin, shRNA interference, Lpl, lipoprotein lipase, carboxy-terminus of Hsc70-interacting protein, INH, isoniazid, Endoplasmic reticulum, lcsh:RM1-950, JNK1, Cytochrome P450, Fas, medicine.disease, lcsh:Therapeutics. Pharmacology, ACOX1, acyl-CoA oxidase 1, Pgc1, CHIP, carboxy-terminus of Hsc70-interacting protein, 3MA, FOXO, CHIP E3 ubiquitin ligase, Steatohepatitis, Digestive Diseases, ASK1, apoptosis signal-regulating kinase, Tnf, tumor necrosis factor, Function (biology), 3MA, 3-methyladenine, UPD, Tnf, AP-1, activator protein 1, Hepatitis, Pathogenesis, AAA, ATPases associated with various cellular activities, autocrine motility factor receptor, FOXO, forkhead box O, shRNAi, SREBP1c, sterol regulatory element binding transcription factor 1c, ACHE, 2.1 Biological and endogenous factors, AAA, Ub, ubiquitin, autophagic-lysosomal degradation, peroxisome proliferator-activated receptor coactivator 1, fatty acid synthase, Insig1, biology, GAPDH, Chemistry, Fatty liver, Substance Abuse, ubiquitin (Ub)-dependent proteasomal degradation, SREBP1c, ACC2, acetyl-CoA carboxylase 2, apoptosis signal-regulating kinase, interleukin 1 β, IRS1, insulin receptor substrate 1, sterol regulatory element binding transcription factor 1c, Lpl, Scd1, ATF2, activating transcription factor 2, isoniazid, ACC1, acetyl-CoA carboxylase 1, gp78/AMFR E3 ubiquitin ligase, tumor necrosis factor, CBZ, carbamazepine, Chronic Liver Disease and Cirrhosis, ACHE, acetylcholinesterase, interleukin 6, ACC1, ACC2, Atg14, AdipoR1, gene of adiponectin receptor 1, medicine, AdipoR1, acyl-CoA oxidase 1, 030304 developmental biology, chemokine (C–C motif) ligand 1, acetyl-CoA carboxylase 2, 3-methyladenine, Autoantibody, insulin receptor substrate 1, Il-1β, interleukin 1 β, Scd1, stearoyl-coenzyme A desaturase, AP-1, ASK1, gene of adiponectin receptor 1, Atg14, autophagy-related 14, Ub, ALD, ALD, autophagic-lysosomal degradation, Mcp1, biology.protein, forkhead box O, gp78/AMFR, autocrine motility factor receptor, acetyl-CoA carboxylase 1, Endoplasmic reticulum-associated degradation, Non-alcoholic fatty liver disease
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b693f8b63f9fc633d41381151847be33Test
https://doi.org/10.1016/j.apsb.2019.11.002Test -
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المؤلفون: Edmond Fleischer, Vincent Kam Wai Wong, Thorsten Berg, Sara Abdelfatah, Thomas Efferth, Anette Klinger, Li Jun Yang, Qi Huang, Sami Hamdoun, Henry Johannes Greten, Angela Berg
المصدر: Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PBD, Polo box domain, MTD, maximal tolerance dose, CDC25, cell division cycle 25, HIF-1α, hypoxia-inducible factor 1 α, MST, microscale thermophoresis, IC50, 50% inhibition concentration, MFP, M phase promoting factor, PARP-1, poly(ADP-ribose) polymerase-1, 0302 clinical medicine, FOXO, forkhead box O, Nec-1, necrostatin 1, CDC2, cell division cycle protein 2 homolog, General Pharmacology, Toxicology and Pharmaceutics, Mitotic catastrophe, CDK, cyclin-dependent kinase, 0303 health sciences, Chemistry, Polo-like kinase, Mono-targeted therapy, Cell cycle, BUBR1, budding uninhibited by benzimidazole-related 1, Polo box domain, 030220 oncology & carcinogenesis, PLK1, Polo-like kinase, Necroptosis, Spindle damage, PLK1, IHC, immunohistochemistry, Original article, APC/C, anaphase-promoting complex/cyclosome, PLK3, ABC, avidin-biotin complex, PI, propidium iodide, 03 medical and health sciences, FBS, fetal bovine serum, PDB, Protein Data Bank, Kd, the dissociation constant, Kinase activity, 030304 developmental biology, Akt/PKB signaling pathway, Cell growth, lcsh:RM1-950, LC3, light chain 3, lcsh:Therapeutics. Pharmacology, Cancer research, DAPKs, death-associated protein kinase, 3-MA, 3-methyladenine, DAPI, 4′,6-diamidino-2-phenylindole, SAC, spindle assembly checkpoint
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ace647c8e4c5307f8c6cf16d50546d6Test
http://www.sciencedirect.com/science/article/pii/S221138351830827XTest -
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المؤلفون: Brandl, Lydia, Zhang, Yina, Kirstein, Nina, Sendelhofert, Andrea, Boos, Sophie Luise, Jung, Peter, Greten, Florian, Rad, Roland, Menssen, Antje
المصدر: Neoplasia (New York, N.Y.)
مصطلحات موضوعية: PARP-1, Poly (ADP-ribose) polymerase 1, Proto-Oncogene Proteins B-raf, Original article, Biopsy, mSA, murine serrated adenomas, IHC, immunohistochemical, Apoptosis, PI, propidium iodide, Proto-Oncogene Proteins c-myc, PDTO, patient-derived tumor organoid, Mice, Phosphatidylinositol 3-Kinases, Sirtuin 1, FOXO, forkhead box O, Cell Line, Tumor, Intestinal Neoplasms, mSA-HGD, murine serrated adenomas with high-grade dysplasia, Animals, ddc:610, MSI, microsatellite instable, Neoplasm Metastasis, Nicotinamide Phosphoribosyltransferase, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, PBEF, pre-B cell enhancing factor, PI3K, phosphatidylinositol 3-kinase, Oncogenes, HTOM, human tumor organoid media, MSS, microsatellite stable, Immunohistochemistry, CRC, colorectal carcinoma, NAMPT, nicotinamide phosphoribosyltransferase, SIRT1, sirtuin-1, CCAR2, cell cycle and apoptosis regulator 2, DBC1, deleted in breast cancer 1, FFPE, formalin-fixed paraffin-embedded, mSH, murine serrated hyperplasia, Cell Transformation, Neoplastic, Drug Resistance, Neoplasm, Mutation, Cytokines, mSA-LGD, murine serrated adenomas with low-grade dysplasia, Biomarkers, Signal Transduction
وصف الملف: application/octet-stream
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6fe6dfb6a26d9e9087f02fe28a19a298Test
http://europepmc.org/articles/PMC6710297Test -
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المؤلفون: David G. Le Couteur, Sun Woo Sophie Kang, Glen P Lockwood, Nicholas J. Hunt, Victoria C. Cogger
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1151-1161 (2019)مصطلحات موضوعية: Systemic disease, LSEC, liver sinusoidal endothelial cell, Review Article, IL-8, interleukin 8, Biochemistry, miR, microRNA, AMPK, 5′ adenosine monophosphate-activated protein kinase, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, FOXO, forkhead box O, Structural Biology, Hepatocyte, αSMA, alpha smooth muscle actin, 0303 health sciences, VEGF, vascular endothelial growth factor, Phenotype, HSC, hepatic stellate cell, 3. Good health, Computer Science Applications, Cell biology, IL-6, interleukin 6, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine.symptom, KC, Küpffer cell, Biotechnology, Senescence, NAFLD, non-alcoholic fatty liver disease, PDGF, platelet derived growth factor, SIRT1, sirtuin 1, CR, caloric restriction, lcsh:Biotechnology, Biophysics, TNFα, tumor necrosis factor alpha, Inflammation, mTOR, mammalian target of rapamycin, Nutrient sensing, Biology, Endothelial, 03 medical and health sciences, ROS, reactive oxygen species, Genetic, lcsh:TP248.13-248.65, Nutrient sensing pathways, Genetics, medicine, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-α, 030304 developmental biology, NO, nitric oxide, Epigenome, medicine.disease, IGF-1, insulin like growth factor 1, Mitochondrial dysfunction, Function (biology)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf961c6cce83782d5f12524960f4f45Test
https://doi.org/10.1016/j.csbj.2019.07.021Test -
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المؤلفون: Dileep N. Lobo, Despina Constantin, Dumitru Constantin-Teodosiu, Paul L. Greenhaff, Kristina K. Varadhan
المصدر: Clinical Nutrition (Edinburgh, Scotland)
مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Critical Care and Intensive Care Medicine, Systemic inflammation, MAFbx, muscle atrophy F-box, TNF-α, tumour necrosis factor α, Postoperative Complications, MuRF1, muscle-RING finger 1, 0302 clinical medicine, IR, insulin resistance, FOXO, forkhead box O, Abdomen, Insulin, Nutrition and Dietetics, Muscle inflammatory responses, Middle Aged, 3. Good health, PDC, pyruvate dehydrogenase complex, Cytokines, LPS, lipopolysaccharide, Female, IRS1, insulin receptor substrate 1, medicine.symptom, Adult, CSTL1, cathepsin, medicine.medical_specialty, Abdominal surgery, Inflammation, Protein degradation, PI3K/Akt1, phosphotidyl inositol 3-kinase/protein kinase B, Article, PPAR, perioxisome proliferator-activated receptor, Proinflammatory cytokine, 03 medical and health sciences, Pancreatectomy, Atrophy, PCA, perchloric acid, Digestive System Physiological Phenomena, Diabetes mellitus, Internal medicine, FFA, free fatty acid, medicine, Humans, Muscle, Skeletal, Herniorrhaphy, business.industry, RA, rectus abdominus, Metabolic response, medicine.disease, IL, interleukin, 030104 developmental biology, Endocrinology, Postoperative hyperglycaemia, VL, vastus lateralis, Hyperglycemia, Blood sugar regulation, Gene expression, business, PDK, pyruvate dehydrogenase kinase, 030217 neurology & neurosurgery
وصف الملف: PDF
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45af6490ed64e6453fc8635e60761a6Test
https://doi.org/10.1016/j.clnu.2017.10.020Test -
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المؤلفون: Yan-Li Li, You-Xiang Yao, Yu-Qin Di, Yu-Meng Zhao, Xiao-Fan Zhao
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, PTEN, HaEpi, Helicoverpa armigera epidermal cell line, INSR, insulin receptor, T2D, Type 2 diabetes, medicine.medical_treatment, IgG, immunoglobin G, DopEcR, dopamine receptor, IGFs, insulin-like growth factors, Moths, DMSO, dimethyl sulfoxide, Biochemistry, hemolymph glucose, DAPI, 4’-6-diamidino-2-phenylindole dihydrochloride, PTP1B, protein tyrosine phosphatase 1B, DILP6, Drosophila melanogaster insulin-like peptide 6, body growth, λPPase, lambda protein phosphatase, Insulin, PIP2, phosphatidylinositol 4,5-diphosphate, PCD, programmed cell death, Phosphorylation, insulin receptor, PTEN, PTEN/MMAC1/TEP1 (phosphatase and tensin homolog deleted on chromosome 10/mutated in multiple advanced cancer 1/TGF-regulated and epithelial cell-enriched phosphatase), SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, GFP, green fluorescent protein, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Chemistry, Forkhead Box Protein O1, Metamorphosis, Biological, p-INSRβ, Phospho-INSRβ, Cell biology, IIS, insulin/insulin-like growth factor-1 (IGF-1) signaling, ChIP, chromatin immunoprecipitation, Ecdysterone, RNAi, RNA interference, RNA Interference, ACTB/β-actin, actin beta, 20-hydroxyecdysone, PG, prothoracic gland, PIP3, phosphatidylinositol 3,4,5-triphosphate, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Research Article, PTPase, tyrosine–protein phosphatase, endocrine system, PI3K, phosphoinositide-3-kinase, PBS, phosphate-buffered saline, DPBS, dulbecco’s phosphate-buffered saline, AKT, protein kinase B, Dephosphorylation, 03 medical and health sciences, qRT-PCR, quantitative real-time reverse transcription PCR, Downregulation and upregulation, FBS, fetal bovine serum, ORF, open reading frame, medicine, Animals, Humans, Molecular Biology, Protein kinase B, FoxOBE, FoxO-binding element, GLUT4, glucose transporter 4, 030102 biochemistry & molecular biology, E20MO, Ecdysone 20-monooxygenase, metamorphosis, FoxO, Forkhead box O, fungi, PTEN Phosphohydrolase, nutritional and metabolic diseases, PTP1B, Estrogens, Cell Biology, PDK1, phosphoinositide-dependent protein kinase 1, Receptor, Insulin, INSRβ, non-Phospho-INSRβ, Insulin receptor, 030104 developmental biology, Gene Expression Regulation, 20E, 20-hydroxyecdysone, biology.protein, dsRNA, double-stranded RNA, PTPN1, FoxO, Co-IP, co-immunoprecipitation, ILPs, insulin-like peptides, GLUT4
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd596f55ed83bd0f07cbb0e2d90f85bTest
https://pubmed.ncbi.nlm.nih.gov/33484713Test -
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المؤلفون: Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)مصطلحات موضوعية: Review, Mitochondrion, PD, Parkinson's disease, 0302 clinical medicine, FOXO, forkhead box O, Mitophagy, HD, Huntington's disease, TFEB, transcription factor EB, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, TIGAR, TP53-induced glycolysis and apoptosis regulator, Stroke, 0303 health sciences, AMPK, 5′-adenosine monophosphate-activated protein kinase, mTOR, mechanistic target of rapamycin, eIF2a, eukaryotic translation-initiation factor 2, PI3K, phosphatidylinositol 3-kinase, OGD/R, oxygen and glucose deprivation-reperfusion, Cerebral ischemia, ALS, amyotrophic lateral sclerosis, PERK, protein kinase R (PKR)-like endoplasmic reticulum kinase, Neuroprotection, Mitochondria, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, ULK, Unc-51- like kinase, AD, Alzheimer's disease, Intracellular, Programmed cell death, ATF6, activating transcription factor 6, IRE1, inositol-requiring enzyme 1, RM1-950, Natural compounds, IPC, ischemic preconditioning, ER, endoplasmic reticulum, 03 medical and health sciences, COPII, coat protein complex II, LKB1, liver kinase B1, ROS, reactive oxygen species, ΔΨm, mitochondrial membrane potential, medicine, Autophagy, Lysosomal activation, ATG, autophagy related genes, 030304 developmental biology, Uro-A, urolithin A, business.industry, FUNDC1, FUN14 domain containing 1, medicine.disease, LC3, light chain 3, GPCR, G-protein coupled receptor, BNIP3L, BCL2/adenovirus, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, Neuroscience, Homeostasis, Neurological disorders, BCL-2, B-cell lymphoma 2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8275a01a7067dd1af9480fcfa0d27454Test
https://pubmed.ncbi.nlm.nih.gov/34386317Test -
9رسالة جامعية
المؤلفون: Grgurica, Karmen
المساهمون: Puizina, Jasna
مصطلحات موضوعية: starenje, dugovječnost, genetika, APOE (apolipoprotein E), sirtuini, FOXO (forkhead box O transkripcijski faktor), ACE (angiotenzin konvertirajući enzim), NOS (dušik oksid sintaza), mTOR (meta rapamicina kod sisavaca), ATM (mutirana ataksija talengiektazija), gerontom, epigenetika, metilacija DNA, acetilacija, DNMT (DNA metiltransferaza), epigenetski sat, aging, longevity, genetics, FOXO (forkhead box O transcription factor), ACE (angiotensin converting enzyme), NOS (nitrogen oxide synthase), mTOR (target rapamycin in mammals), ATM (mutated ataxia talengiectasia), epigenetics, DNA methylation, acetylation, DNMT (DNA methyltransferase), epigenetic clock, PRIRODNE ZNANOSTI. Biologija
وصف الملف: application/pdf
العلاقة: https://repozitorij.svkst.unist.hr/islandora/object/pmfst:1788Test; https://urn.nsk.hr/urn:nbn:hr:166:020801Test; https://repozitorij.svkst.unist.hr/islandora/object/pmfst:1788/datastream/PDFTest
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المؤلفون: Mizuki Inoue, Shinji Miura, Yui Watanabe, Tomoki Sato, Akihito Morita, Yuri Nishimura
المصدر: Biochemistry and Biophysics Reports, Vol 18, Iss, Pp-(2019)
Biochemistry and Biophysics Reportsمصطلحات موضوعية: PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha, 0301 basic medicine, medicine.medical_specialty, PI3K, phosphoinositide-3-kinase, medicine.medical_treatment, Biophysics, FOXO1, Fructose, FoxO, forkhead box O, Biochemistry, G6Pase, glucose-6-phosphatase, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, FFA, free fatty acid, medicine, Insulin, Lipolysis, lcsh:QD415-436, lcsh:QH301-705.5, EDTA, ethylenediaminetetraacetic acid, SREBP, sterol-regulatory element binding protein, AKT, G6Pase, Fatty liver, Gluconeogenesis, ChREBP, carbohydrate response element binding protein, medicine.disease, 030104 developmental biology, Endocrinology, PIP 3, phosphatidylinositol-(3,4,5)-trisphosphate, lcsh:Biology (General), chemistry, FoxO1, CREB, cAMP response element binding protein, 030220 oncology & carcinogenesis, Lipogenesis, Ketone bodies, PEPCK, phosphoenolpyruvate carboxykinase, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2cfe7d74f376b9f84f095d1935b7c2Test
https://doi.org/10.1016/j.bbrep.2019.100638Test