نتائج البحث - "FDR, False discovery rate"

1

دورية أكاديمية

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

المؤلفون: Tattersall, Luke, Shah, Karan, M, Lath, Darren, L, Singh, Archana, Down, Jennifer, M, de Marchi, Elena, Williamson, Alex, Di Virgilio, Francesco, Heymann, Dominique, Adinolfi, Elena, Fraser, William, D, Green, Darrell, Lawson, Michelle, A, Gartland, Alison

المساهمون: University of Sheffield Sheffield, University of East Anglia Norwich (UEA), Università degli Studi di Ferrara = University of Ferrara (UniFE), Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), UNICANCER, Norwich University

المصدر: ISSN: 2212-1374 ; Journal of Bone Oncology ; https://inserm.hal.science/inserm-03878089Test ; Journal of Bone Oncology, 2021, 31, pp.100398. ⟨10.1016/j.jbo.2021.100398⟩.

مصطلحات موضوعية: ATP, ATP : Adenosine Triphosphate, Bone cancer, BzATP : Benzoyl ATP, DE : Differentially Expressed, ECM : Extracellular Matrix, EMT : Epithelial–mesenchymal transition, FDR : False Discovery Rate, HBSS : Hanks Balanced Salt Solution, LOX : Lysyl Oxidase, MMPs : Matrix Metalloproteinases, OS : Osteosarcoma, Osteosarcoma, P2RX7B, PE : Paired End, Purinergic signalling, qRT-PCR : Quantitative Reverse Transcription Polymerase Chain Reaction, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.CAN]Life Sciences [q-bio]/Cancer

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35340569; inserm-03878089; https://inserm.hal.science/inserm-03878089Test; https://inserm.hal.science/inserm-03878089/documentTest; https://inserm.hal.science/inserm-03878089/file/1-s2.0-S2212137421000531-main.pdfTest; PUBMED: 35340569; PUBMEDCENTRAL: PMC8948168

الإتاحة: https://doi.org/10.1016/j.jbo.2021.100398Test
https://inserm.hal.science/inserm-03878089Test
https://inserm.hal.science/inserm-03878089/documentTest
https://inserm.hal.science/inserm-03878089/file/1-s2.0-S2212137421000531-main.pdfTest

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2

دورية أكاديمية

Transcriptomic landscapes of effective and failed liver regeneration in humans.

المؤلفون: Starlinger, Patrick, Brunnthaler, Laura, McCabe, Chantal, Pereyra, David, Santol, Jonas, Steadman, Jessica, Hackl, Matthias, Skalicky, Susanna, Hackl, Hubert, Gronauer, Raphael, O'Brien, Daniel, Kain, Renate, Hirsova, Petra, Gores, Gregory J, Wang, Chen, Gruenberger, Thomas, Smoot, Rory L, Assinger, Alice

المصدر: JHEP Rep ; ISSN:2589-5559 ; Volume:5 ; Issue:4

مصطلحات موضوعية: ALT, alanine aminotransferase, AST, aspartate aminotransferase, CASH, chemotherapy associated steatohepatitis, DLR, dysfunctional LR, DUSP-4, DUSP4, dual-specificity phosphatase 4, FDR, false discovery rate, FLR, functional LR, FPKM, fragments per kilobase of transcript per million mapped reads, Human, ICAM-1, intracellular adhesion molecule-1, IPA, Ingenuity Pathway Analysis, IVCL, inferior vena cava ligation, Inflammation, LPS, lipopolysaccharide, LR, liver regeneration, LSEC, liver sinusoidal endothelial cell, Liver regeneration, MFI, mean fluorescence intensity, MPO, myeloperoxidase, NASH, non-alcoholic steatohepatitis, Neutrophils, PCA, principal component analysis, POD1, 1 day after liver resection, POD5, 5 days after liver resection, STRING, Search Tool for the Retrieval of Interacting Genes/Proteins, TMM, trimmed mean of M values, TNF, tumour necrosis factor, logCPM, log counts per million, pTPM, protein-coding transcripts per million

العلاقة: https://doi.org/10.1016/j.jhepr.2023.100683Test; https://pubmed.ncbi.nlm.nih.gov/36950091Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025111Test/

الإتاحة: https://doi.org/10.1016/j.jhepr.2023.100683Test
https://pubmed.ncbi.nlm.nih.gov/36950091Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025111Test/

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3

Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver

المؤلفون: Banrida Wahlang, Monika Thapa, Michael L. Merchant, Jian Jin, Sudhir Srivastava, Josiah E. Hardesty, Russell A. Prough, Shesh N. Rai, Matthew C. Cave, Kimberly Z. Head

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3806-3819 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: WT, wild type, TAT, tyrosine aminotransferase, PCB126, AHR, IGF1, insulin-like growth factor 1, PCB, polychlorinated biphenyl, Blood lipids, FGF21, fibroblast growth factor 21, miR, microRNA, Pheromones, AHR, aryl hydrocarbon receptor, AUC, area under the curve, Liver disease, HFD, high fat diet, AST, aspartate transaminase, LDL, low-density lipoprotein, VLDL, very low-density lipoprotein, Environmental liver disease, General Pharmacology, Toxicology and Pharmaceutics, Receptor, MUP, major urinary protein, ANOVA, analysis of variance, NFKBIA, nuclear factor kappa-inhibitor alpha, PNPLA3, patatin-like phospholipase domain-containing protein 3, biology, ZFP125, zinc finger protein 125, PXR, pregnane-xenobiotic receptor, MCP-1, monocyte chemoattractant protein-1, respiratory system, EPF, enrichment by protein function, IL-6, interleukin 6, nHDLc, non-HDL cholesterol, IPF, interaction by protein function, PAI-1, plasminogen activator inhibitor-1, PLIN2, perilipin-2, Proteome, CYP, cytochrome P450, Original Article, CAR, constitutive androstane receptor, SGK1, serum/glucocorticoid regulated kinase, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, FDR, false discovery rate, ALT, alanine transaminase, Endocrine disruption, HDL, high-density lipoprotein, H&E, hematoxylin-eosin, RM1-950, CD36, cluster of differentiation 36, Perilipin-2, Internal medicine, medicine, Nonalcoholic fatty liver disease, Pheromone binding, GO, gene ontology, TASH, toxicant-associated steatohepatitis, PPARα, peroxisome proliferator-activated receptor alpha, TAFLD, toxicant-associated fatty liver disease, TMT, tandem mass tag, medicine.disease, Aryl hydrocarbon receptor, Insulin receptor, Endocrinology, biology.protein, GCR, glucocorticoid receptor, Therapeutics. Pharmacology, Steatosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd0117be990219f236c36406e5afea7Test
https://doi.org/10.1016/j.apsb.2021.10.014Test

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MicroRNA-regulated transcriptome analysis identifies four major subtypes with prognostic and therapeutic implications in prostate cancer

المؤلفون: Guolong Liao, Hanqi Lei, Xiangwei Yang, Xing Fu, Fu Shi, Donggen Jiang, Haiyun Xiong, Yafei Yang, Yu-Peng Feng, Jun Pang, Bing-Biao Lin

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4941-4953 (2021)

مصطلحات موضوعية: Microarray, DFS, disease-free survival, MDSCs, myeloid-derived suppressor cells, AUC, Area under the dose-response curve, Biochemistry, k-NN, K-nearest neighbor, GEP, gene expression profile, Androgen deprivation therapy, Transcriptome, CTLA-4, cytotoxic T-lymphocyte associated protein-4, chemistry.chemical_compound, Prostate cancer, DEmiRs, differentially expressed miRNAs, SCNAs, somatic copy number alterations, Structural Biology, TGFβ, transforming growth factor β, BCR, biochemical recurrence, ICB, immune checkpoint blockade, GEO, Gene Expression Omnibus, NTP, Nearest template prediction, TMB, tumor mutation burden, PD-1, programmed cell death protein-1, NEPC, neuroendocrine prostate cancer, Computer Science Applications, NMF, non-negative matrix factorization, CCLs, cancer cell lines, Tregs, regulatory T cells, miRNAs, EMT, epithelial-mesenchymal transition, mCRPC, metastatic castration-resistant prostate cancer, Biotechnology, Research Article, FDR, false discovery rate, SubMap, Subclass mapping, Molecular subtypes, Biophysics, PCa, prostate cancer, Biology, KEGG, Kyoto Encyclopedia of Genes and Genomes, Olaparib, OS, overall survival, GSEA, Gene Set Enrichment Analysis, microRNA, GO, Gene Ontology, ssGSEA, single-sample gene set enrichment analysis, Genetics, medicine, TNAs, tumor neoantigens, PTEN, miRNAs, microRNAs, IFN, interferon, ADT, androgen deprivation therapy, ComputingMethodologies_COMPUTERGRAPHICS, Taxane, medicine.disease, PD-L1, programmed death-ligand 1, chemistry, Cancer research, biology.protein, TCGA, The Cancer Genome Atlas, MIRcor, miRNA-correlated, AR, androgen receptor, Heterogeneity, TP248.13-248.65, CAFs, cancer-associated fibroblasts

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f138460d0ba30547d9145ec00105384eTest
http://europepmc.org/articles/PMC8433071Test

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Molecular Signature of HFpEF

المؤلفون: John W. Elrod, Steven R. Houser, Markus Wallner, Remus M. Berretta, Dhanendra Tomar, Anh T Huynh, Joanne F Garbincius, Deborah M Eaton, Emma K Murray, Devin W. Kolmetzky, Andrew A. Gibb

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: MS/MS, tandem mass spectrometry, FDR, false discovery rate, Systems biology, ETC, electron transport chain, heart failure, HFpEF, heart failure with preserved ejection fraction, Mitochondrion, Biology, HF, heart failure, UPLC, ultraperformance liquid chromatography, Transcriptome, transcriptomics, Metabolomics, medicine, EF, ejection fraction, LA, left atrial, LAV, left atrial volume, m/z, mass to charge ratio, HFrEF, heart failure with reduced ejection fraction, GO, gene ontology, Maladaptation, ESI, electrospray ionization, LV, left ventricle/ventricular, Skeletal muscle, systems biology, FC, fold change, medicine.disease, metabolomics, preserved ejection fraction, ECM, extracellular matrix, Cell biology, mitochondria, BCAA, branched chain amino acids, medicine.anatomical_structure, RI, retention index, Heart failure, Preclinical Research, RCR, respiratory control ratio, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, DAG, diacylglycerol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474acd63270db1077349e2d878112f6bTest
https://doi.org/10.1016/j.jacbts.2021.07.004Test

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Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 754-765 (2021)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: Cancer Research, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Matrix metalloproteinase, VAMP7, vesicle-associated membrane protein 7, GST, glutathione S-transferase, Metastasis, Invasion, Cell Movement, Gene expression, Tumor Microenvironment, APMA, 4-aminophenylmercuric acetate, Neoplasm Metastasis, ANOVA, analysis of variance, RC254-282, Original Research, Gene knockdown, Malignant, Cell adhesion molecule, Chemistry, Brain Neoplasms, food and beverages, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, empty cells, C6 cells transfected with an empty vector, Prognosis, Immunohistochemistry, EGFP, enhanced green fluorescent protein, PFS, progression-free survival, Gene Expression Regulation, Neoplastic, CLIC, chloride intracellular channel protein, MMP, matrix metalloproteinase, Benign, PM, plasma membrane, Distant metastasis, MMP14, Intracellular, Protein Binding, FDR, false discovery rate, Brain tumor, CC3, cleaved caspase 3, qPCR, quantitative real-time RT-PCR, C6 cells, original C6 glioma cells, Capillary Permeability, TAM, tumor-associated macrophages, TIMP2, tissue inhibitor of metalloproteinase 2, CC cells, C6 cells transfected with C-terminally FLAG-tagged rat CLIC2 cDNA, Chloride Channels, Cell Line, Tumor, medicine, Matrix Metalloproteinase 14, Animals, Humans, Neoplasm Invasiveness, Gene Silencing, VE-cadherin, vascular endothelial cadherin, Neoplasm Staging, PCA, principal component analysis, Gene Expression Profiling, NNGH, N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid, RNA-seq, RNA sequencing, FACS, fluorescence activated cell sorting, GBM, glioblastoma multiforme, medicine.disease, Rats, Enzyme Activation, E-cadherin, epithelial cadherin, Cancer research, GSC, glioblastoma stem-like cell, Neoplasm Grading

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a1857fc7fdf8e1121e51752c54bf4fTest
http://www.sciencedirect.com/science/article/pii/S1476558621000439Test

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Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic Signatures

المؤلفون: Barbara Joanna Niklinska-Schirtz, Murugadas Anbazhagan, Anil G. Jegga, Vasantha L. Kolachala, Suresh Venkateswaran, Lee A. Denson, Raghavan Chinnadurai, Jason D. Matthews, Subra Kugathasan, Gregory Gibson, David J. Cutler, Anne Dodd, Jarod Prince

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)

مصطلحات موضوعية: Biopsy, RC799-869, Inflammatory bowel disease, Severity of Illness Index, PDGF, platelet-derived growth factor, Transcriptome, PCR, polymerase chain reaction, Crohn Disease, Gene expression, DEG, differentially expressed gene, PDO, patient-derived organoid, FDR, false discovery rate correction, Gene Regulatory Networks, Intestinal Mucosa, Children, Original Research, Secretome, Crohn's disease, Human Intestinal Organoids, Gastroenterology, Diseases of the digestive system. Gastroenterology, Intestinal epithelium, Phenotype, DE, differentially expressed, VEGF, vascular endothelial growth factor, Organoids, medicine.anatomical_structure, Epigenetics, RIN, RNA integrity number, PBS, phosphate-buffered saline, Biology, In vivo, Ileum, Organoid, medicine, CD, Crohn’s disease, Humans, Metabolomics, Gene, PCA, principal component analysis, Hepatology, Gene Expression Profiling, Inflammatory Bowel Disease, RNA, Computational Biology, FC, fold change, medicine.disease, Intestinal Epithelium, Molecular biology, Epithelium, UC, ulcerative colitis, Gene Expression Regulation, Case-Control Studies, GPCR, G protein–coupled receptor, IBS, inflammatory bowel disease