Clinical outcome of adjuvant radiotherapy for squamous cell carcinoma of the breast; a multicenter retrospective cohort study
| العنوان: | Clinical outcome of adjuvant radiotherapy for squamous cell carcinoma of the breast; a multicenter retrospective cohort study |
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| المؤلفون: | Mami Ogita, Hideomi Yamashita, Kenji Tokumasu, Kenshiro Shiraishi, Jiro Kawamori, Naomi Nakajima, Katsuyuki Karasawa, Ta-Chen Chang, Keiichi Nakagawa |
| المصدر: | Breast, Vol 52, Iss, Pp 88-94 (2020) The Breast : official journal of the European Society of Mastology |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, PMRT, post-mastectomy radiotherapy (PMRT), ER, estrogen receptor, Lymphovascular invasion, medicine.medical_treatment, SCC, squamous cell carcinoma, AC, doxorubicin and cyclophosphamide, Cohort Studies, 0302 clinical medicine, Breast cancer, Risk Factors, Recurrence, Squamous cell carcinoma, HER2, human epidermal growth factor receptor 2, 030212 general & internal medicine, Lymph node, Aged, 80 and over, CMF, cyclophosphamide, methotrexate, and 5-fluorouracil, BCSS, breast cancer-specific survival, Incidence (epidemiology), General Medicine, Middle Aged, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, RFi, recurrence-free interval, 030220 oncology & carcinogenesis, Lymphatic Metastasis, FEC, epirubicin and cyclophosphamide, Carcinoma, Squamous Cell, Female, Original Article, IDC, invasive ductal carcinoma, Mastectomy, PARP, poly (ADP-ribose) polymerase, Adult, medicine.medical_specialty, FAP, 5-FU, cisplatin and doxorubicin, RNI, regional nodal irradiation, Breast Neoplasms, UICC, the Union for International Cancer Control, CTCAE, the Common Terminology Criteria for Adverse Events, lcsh:RC254-282, OS, overall survival, 03 medical and health sciences, Internal medicine, medicine, Humans, EBCTCG, the Early Breast Cancer Trialists’ Collaborative Group, Aged, Retrospective Studies, Radiotherapy, business.industry, Retrospective cohort study, medicine.disease, SEER, the Surveillance, Epidemiology and End Results, Survival Analysis, EGFR, epidermal growth factor receptor, Radiation therapy, PgR, progesterone receptor, Surgery, Radiotherapy, Adjuvant, Neoplasm Recurrence, Local, business, Rare disease |
| الوصف: | Background Because primary squamous cell carcinoma (SCC) of the breast is a rare disease, the standard therapy has not been established. We examined the clinical outcomes of postoperative adjuvant radiotherapy for breast SCC. Material and methods We conducted a multicenter retrospective cohort study. Patients diagnosed with primary breast SCC who received adjuvant radiotherapy as part of their primary definitive treatment were included. Overall survival (OS), breast cancer-specific survival (BCSS), and recurrence-free interval (RFi) were evaluated. Results Between January 2002 and December 2017, 25 breast SCC patients received adjuvant radiotherapy as a primary treatment were included. Median follow-up time was 43.5 months. Three (12%), fifteen (60%) and seven (28%) patients had clinical stage I, II and III disease, respectively. Fourteen patients underwent breast-conserving surgery and subsequent adjuvant radiotherapy. Eleven patients underwent mastectomy and post-mastectomy radiotherapy. Ten patients received regional lymph node irradiation. Nine (36%) patients had disease recurrence. The first site of recurrence was locoregional in five, but distant metastasis arose in one. Concurrent local and distant metastasis were seen in two. Six cases of local recurrence occurred within the irradiated site. Seven patients died, and six of the deaths were due to breast cancer. Five-year OS, BCSS, and Rfi were 69%, 70%, and 63%, respectively. In multivariate analysis, age and lymphatic invasion were associated with increased risk of recurrence. Conclusion Breast SCC has a high incidence of locoregional recurrence and poor prognosis. Age and lymphatic invasion are significant risk factors for recurrence. Highlights • Clinical outcome of adjuvant radiotherapy for SCC of the breast was evaluated. • Breast SCC had poor prognosis and a high incidence of locoregional recurrence. • In-field recurrence following radiotherapy occurred frequently. • Age and lymphatic invasion were significantly associated with increased risk of recurrence. |
| اللغة: | English |
| تدمد: | 1532-3080 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cd3dd2311652559da301e9ed118ed7Test http://www.sciencedirect.com/science/article/pii/S0960977620301107Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....83cd3dd2311652559da301e9ed118ed7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15323080 |
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