نتائج البحث

المساهمون: M.C. Cardia, M.F. Palma, L. Casula, A. Pisanu, S. Marceddu, D. Valenti, C. Sinico, E. Pini, M.T. Scerba, D. Tweedie, N.H. Greig, A.R. Carta, F. Lai

مصطلحات موضوعية: Brain, Nanocrystal, Nanosuspension, Neurological disorder, Pomalidomide, Settore CHIM/06 - Chimica Organica, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35932932; info:eu-repo/semantics/altIdentifier/wos/WOS:000855333600005; volume:625; firstpage:1; lastpage:9; numberofpages:9; journal:INTERNATIONAL JOURNAL OF PHARMACEUTICS; http://hdl.handle.net/2434/937275Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135720294

الإتاحة: https://doi.org/10.1016/j.ijpharm.2022.122079Test
http://hdl.handle.net/2434/937275Test

View record in BASE

4

Maintenance in Process Industries with Digital Twins and Mixed Reality: Potentials, Scenarios and Requirements

المؤلفون: L. Rudolph, D. Pantforder, F. Palmas, M. Fischer, P. Niermann, G. Klinker, B. Vogel-Heuser

المصدر: 2022 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cd23be2eb8f5900c6fc7023b70028d5fTest
https://doi.org/10.1109/ieem55944.2022.9989826Test

5

Cystic Fibrosis: Dietary Adherence And Quality Of Life

المؤلفون: M. Ricart, A. Zabalegui, A. Álvarez, G.E. Cárdenas, A. Lluch, L. Andurell, F. Palmas, V. Avilés, M. Gómez, B. Sarto, R. Lorite, H. Segurola, R. Burgos

المصدر: Clinical Nutrition ESPEN. 54:558-559

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0843771304e1426cc2ee9e1d1c1d6723Test
https://doi.org/10.1016/j.clnesp.2022.09.297Test

6

دورية أكاديمية

Preliminary metabolomics analysis of placenta in maternal obesity

المؤلفون: C. Fattuoni, C. Mandò, F. Palmas, G. M. Anelli, C. Novielli, E. Parejo Laudicina, V. M. Savasi, L. Barberini, A. Dessì, R. Pintus, V. Fanos, A. Noto, I. Cetin

المساهمون: C. Fattuoni, C. Mandò, F. Palma, G.M. Anelli, C. Novielli, E. Parejo Laudicina, V.M. Savasi, L. Barberini, A. Dessì, R. Pintu, V. Fano, A. Noto, I. Cetin

مصطلحات موضوعية: GC-MS, Metabolomic, Obesity, Placenta, Pregnancy, Reproductive Medicine, Obstetrics and Gynecology, Developmental Biology, Settore MED/40 - Ginecologia e Ostetricia, Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica, Settore BIO/11 - Biologia Molecolare

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29277276; info:eu-repo/semantics/altIdentifier/wos/WOS:000418598500012; volume:61; firstpage:89; lastpage:95; numberofpages:7; journal:PLACENTA; http://hdl.handle.net/2434/545200Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85036564843

الإتاحة: https://doi.org/10.1016/j.placenta.2017.11.014Test
http://hdl.handle.net/2434/545200Test

View record in BASE

7

Impact Of Refeeding Syndrome In Oncohaematological Patients After Starting Parenteral Nutrition

المؤلفون: P. Costa Forner, F. Palmas, A. Zabalegui, M. Gómez, L. Andurell, G. Cárdenas, A. Lluch, M. Ricart, R. Burgos

المصدر: Clinical Nutrition ESPEN. 54:610

مصطلحات موضوعية: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7ce0f29741d0915a5914f87ff85d8c5cTest
https://doi.org/10.1016/j.clnesp.2022.09.447Test

8

دورية أكاديمية

Metabolomic analysis of placenta tissue in obese pregnancies

المؤلفون: C. Fattuoni, C. Mandò, F. Palmas, G. M. Anelli, C. Novielli, E. Parejo Laudicina, V. M. Savasi, L. Barberini, A. Dessì, R. Pintus, V. Fanos, A. Noto, I. Cetin

المساهمون: C. Fattuoni, C. Mandò, F. Palma, G.M. Anelli, C. Novielli, E. Parejo Laudicina, V.M. Savasi, L. Barberini, A. Dessì, R. Pintu, V. Fano, A. Noto, I. Cetin

مصطلحات موضوعية: INTRODUCTION: The placenta plays a pivotal role as it represents the connection between mother and foetus. It acts as a carrier (nutrients and oxygen, waste products and carbonic anhydride) as well as a barrier against infection. Pregnancy related metabolomics has examined different biofluids in order to reach deeper insights into pregnancy pathologies [1]. Amniotic fluid, urine and plasma were the most studied, while placenta tissue has been the subject of few studies [2]. In this report, a method to analyse the placental metabolome through the GC-MS (Gas Chromatography-Mass Spectrometry) technique is described. MATERIALS AND METHODS: Placenta tissues were collected after elective caesarean section from obese and normal weight mothers, snap frozen and stored at -80°C until analysis. Each sample was homogenized with a mixture of solvents (chloroform, methanol, water), centrifuged, and the obtained phases were separated and processed following two different protocols. The hydrophilic phase was vacuum dried and treated with two derivatizing reagents, methoxyamine hydrochloride and MSTFA (N-Methyl-N-[trimethylsilyl] trifluoroacetamide), to give a mixture of trimethylsilylated metabolites. The lipophilic phase was dried and treated with boron trifluoride in methanol to obtain a mixture of FAME (Fatty Acid Methyl Esters). The two phases were separately analysed on a GC-MS platform, applying different instrumental conditions. The chromatograms obtained were analysed with the free software AMDIS (Automated Mass Spectral Deconvolution and Identification System) using a lab-made library comprising 200 metabolites. RESULTS: The analysis of the placenta tissue allowed to identify essential metabolites. In the hydrophilic fraction, 78 metabolites were detected: they mainly belong to the classes of amino acids (18), carboxylic acids (13), sugars and sugar-related compounds (11), phosphorylated derivatives (9). The lipophilic fraction analysis allowed to define the fatty acid profile of the placenta extract: the saturated fatty acids palmitic and stearic, the monounsaturated oleic, and the polyunsaturated (PUFA) linoleic, arachidonic, 8,11,14-eicosatrienoic and 4,7,10,13,16,19-docosahexaenoic acid (DHA) were the most representative. Statistical analysis of the data matrices derived from the hydrophilic and lipophilic fraction analysis were performed in MetaboAnalyst 3.0 [3], to investigate the possibility of identifying characteristic metabolic differences between the different phenotypes. Placentae from obese mothers were compared with those from normal weight mothers to get new insights into the correlation between the metabolite content and metabolic status. CONCLUSIONS: The reported analysis method allowed to examine different metabolites in placenta samples, divided into two phases, hydrophilic and lipophilic. All metabolites were analysed through the same GC-MS platform to provide interesting informations about the placenta tissue composition. REFERENCES [1] Fanos V, Atzori L, Makarenko K, Melis GB, Ferrazzi E. Metabolomics application in maternal-fetal medicine. Biomed Res Int. 2013, 2013: 720514. [2] Dunn WB, Brown M

العلاقة: International Workshop on Neonatology; volume:6; issue:2; firstpage:81; lastpage:82; numberofpages:2; journal:JOURNAL OF PEDIATRIC AND NEONATAL INDIVIDUALIZED MEDICINE; http://hdl.handle.net/2434/545220Test

الإتاحة: http://hdl.handle.net/2434/545220Test

View record in BASE

9

An in-depth assessment of variability in image quality across five different CT scanners as clinically used for routine head examinations

المؤلفون: P. Barca, F. Paolicchi, G. Aringhieri, F. Palmas, D. Marfisi, M.E. Fantacci, D. Caramella, M. Giannelli

المصدر: Physica Medica. 92:S119-S120

مصطلحات موضوعية: Biophysics, General Physics and Astronomy, Radiology, Nuclear Medicine and imaging, General Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3e701b98b81875e4d93dc054ca1d5f11Test
https://doi.org/10.1016/s1120-1797Test(22)00254-x

10

1724P Prognostic parameters at admission as predictors of hospital length of stay (HLOS) and overall survival (OS) in hospitalized oncologic patients (pts) of a tertiary hospital

المصدر: Annals of Oncology. 32:S1195-S1196

مصطلحات موضوعية: medicine.medical_specialty, Oncology, business.industry, Internal medicine, medicine, Overall survival, Length of hospitalization, Hematology, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::15647de44ce7ab0da866b5bc85d746bdTest
https://doi.org/10.1016/j.annonc.2021.08.1696Test

تنقيح النتائج