دورية أكاديمية
Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study
| العنوان: | Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study |
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| المؤلفون: | Bahls, Martin, Leitzmann, Michael F., Karch, André, Teumer, Alexander, Dörr, Marcus, Felix, Stephan B., Meisinger, Christa, Baumeister, Sebastian E., Baurecht, Hansjörg |
| المصدر: | http://lobid.org/resources/99370674986806441Test#!, 110(10):1564-1573. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Ischemic Stroke/genetics [MeSH], 2 sample MR, Coronary Artery Disease/genetics [MeSH], Aged [MeSH], Brain Ischemia/etiology [MeSH], Polymorphism, Single Nucleotide [MeSH], Myocardial Infarction/etiology [MeSH], Brain Ischemia/epidemiology [MeSH], Sedentary Behavior [MeSH], Coronary Artery Disease, Risk Factors [MeSH], Exercise/genetics [MeSH], Male [MeSH], Female [MeSH], Ischemic Stroke/epidemiology [MeSH], Adult [MeSH], Humans [MeSH], Accelerometry [MeSH], Myocardial Infarction/genetics [MeSH], Brain Ischemia/genetics [MeSH], Middle Aged [MeSH], Genome-Wide Association Study [MeSH], Coronary Artery Disease/epidemiology [MeSH], Myocardial Infarction/epidemiology [MeSH], Coronary Artery Disease/etiology [MeSH], Original Paper, Physical activity, Mendelian Randomization Analysis [MeSH], Ischemic Stroke/etiology [MeSH] |
| الوصف: | Aims!#!Observational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to examine whether genetically predicted PA and sedentary behavior are related to coronary artery disease, myocardial infarction, and ischemic stroke.!##!Methods and results!#!We used single nucleotide polymorphisms (SNPs) associated with self-reported moderate to vigorous PA (n = 17), accelerometer based PA (n = 7) and accelerometer fraction of accelerations > 425 milli-gravities (n = 7) as well as sedentary behavior (n = 6) in the UK Biobank as instrumental variables in a two sample MR approach to assess whether these exposures are related to coronary artery disease and myocardial infarction in the CARDIoGRAMplusC4D genome-wide association study (GWAS) or ischemic stroke in the MEGASTROKE GWAS. The study population included 42,096 cases of coronary artery disease (99,121 controls), 27,509 cases of myocardial infarction (99,121 controls), and 34,217 cases of ischemic stroke (404,630 controls). We found no associations between genetically predicted self-reported moderate to vigorous PA, accelerometer-based PA or accelerometer fraction of accelerations > 425 milli-gravities as well as sedentary behavior with coronary artery disease, myocardial infarction, and ischemic stroke.!##!Conclusions!#!These results do not support a causal relationship between PA and sedentary behavior with risk of coronary artery disease, myocardial infarction, and ischemic stroke. Hence, previous observational studies may have been biased. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6447541Test; https://doi.org/10.1007/s00392-021-01846-7Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484185Test/ |
| DOI: | 10.1007/s00392-021-01846-7 |
| الإتاحة: | https://doi.org/10.1007/s00392-021-01846-7Test https://repository.publisso.de/resource/frl:6447541Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484185Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C6364CE1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00392-021-01846-7 |
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