Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study
| العنوان: | Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study |
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| المؤلفون: | Estomih Mdumah, Shahida Qureshi, Anita K. M. Zaidi, Dennis Lang, Pablo Peñataro Yori, Margaret Kosek, Sanjaya K. Shrestha, Jean Gratz, Erling Svensen, Tahmeed Ahmed, Caroline Amour, Michael Gottlieb, Pascal O. Bessong, James A Platts-Mills, Eric R. Houpt, Ladaporn Bodhidatta, Ramanujam Karthikeyan, Aldo A. M. Lima, Richard L. Guerrant, Jessica C. Seidman, Jasmin Shrestha, Gagandeep Kang, Amidou Samie, Rashidul Haque, Sudhir Babji, Venkata Raghava Mohan, Monica McGrath, Emanuel Nyathi |
| المصدر: | The Journal of Infectious Diseases. 216:305-316 |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Diarrhea, Male, Pediatrics, medicine.medical_specialty, International Cooperation, 030231 tropical medicine, Disease, Antibodies, Viral, medicine.disease_cause, Rotavirus Infections, Major Articles, Cohort Studies, Feces, 03 medical and health sciences, Age Distribution, fluids and secretions, 0302 clinical medicine, Rotavirus, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, business.industry, Transmission (medicine), Incidence, Incidence (epidemiology), Vaccination, Infant, Newborn, Rotavirus Vaccines, Infant, Overcrowding, Gastroenteritis, Rotavirus infection, Infectious Diseases, Child, Preschool, Regression Analysis, Female, medicine.symptom, business |
| الوصف: | Background In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Methods Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. Results A total of 1737 children contributed 22646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Conclusions Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines. |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b06deac50bfb6b2168ce765affbbc7fTest https://doi.org/10.1093/infdis/jix199Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b06deac50bfb6b2168ce765affbbc7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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