المؤلفون: Shilpi Arora, Anna Kohlmann, Christopher D. Hupp, Julie Liu, Christelle Huguet, Allison Olszewski, Moritz von Rechenberg, John W. Cuozzo, Ying Zhang, Katy E Georgiadis, Matthew A. Clark, Esther C.Y. Lee, Charles J. Eyermann, Andrew J. McRiner, Paolo A. Centrella, Michael I Monteiro, Anthony D. Keefe, Benjamin Levin, Andrew D. Ferguson, Zooey Wang, Yanbin Liu

المصدر: Journal of Medicinal Chemistry. 64:6730-6744

مصطلحات موضوعية: Male, Indoles, Crystallography, X-Ray, 01 natural sciences, Chemical library, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Transaminases, 030304 developmental biology, ADME, 0303 health sciences, Oxidase test, Binding Sites, Chemistry, DNA, Metabolism, 0104 chemical sciences, Molecular Docking Simulation, Alcohol Oxidoreductases, Thiazoles, 010404 medicinal & biomolecular chemistry, Biochemistry, Drug Design, Hyperoxaluria, Primary, Molecular Medicine, Glucuronide, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecd410b881fad4a6d7e1db049c6ba5cTest
https://doi.org/10.1021/acs.jmedchem.0c02271Test

المؤلفون: Diana Gikunju, John W. Cuozzo, Yelena A Arnautova, Sarah A Talcott, Neil Westlund, Andrew J. McRiner, Anthony D. Keefe, Yan Yu, Christelle Huguet, Moritz von Rechenberg, Fei Zhou, Jennifer M Duffy, Shilpi Arora, Esther C.Y. Lee, Ying Zhang, Benjamin Levin, Matthew A. Clark, Jeremy S. Disch, Junyi Zhang, Yanbin Liu, Anton Kozhushnyan, Betty Chan, Anthony C Lau, Michael I Monteiro, Patrick B. Mullins, Anna Kohlmann

المصدر: Journal of Medicinal Chemistry. 64:5049-5066

مصطلحات موضوعية: Indoles, Cell Survival, Estrogen receptor, Breast Neoplasms, Chemical library, Small Molecule Libraries, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Aromatase, biology, Chemistry, DNA-encoded chemical library, Estrogen Antagonists, Estrogen Receptor alpha, DNA, Xenograft Model Antitumor Assays, Small molecule, Kinetics, Biochemistry, Click chemistry, biology.protein, Molecular Medicine, Click Chemistry, Female, Linker, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7302cad9922daa210279c4d6224ee0Test
https://doi.org/10.1021/acs.jmedchem.1c00127Test

المؤلفون: Chris Limberakis, Allyn T. Londregan, Steven B. Coffey, Gary Erik Aspnes, Janice A. Brown, Kevin D. Hesp, Rhys M. Jones, Elnaz Menhaji-Klotz, Esther C.Y. Lee, Markus Boehm

المصدر: Bioorganicmedicinal chemistry letters. 50

مصطلحات موضوعية: Male, Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Biochemistry, Chemokine receptor, Mice, Structure-Activity Relationship, Drug Delivery Systems, In vivo, Drug Discovery, Animals, Immunologic Factors, Molecular Biology, Receptors, CXCR, Molecular Structure, Chemistry, Organic Chemistry, Small molecule, Mice, Inbred C57BL, Drug Design, Lipophilicity, Molecular Medicine, Immunological diseases, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814f75791497d041702db0bd1f7ff5dbTest
https://pubmed.ncbi.nlm.nih.gov/34400299Test

المؤلفون: Kimberly O. Cameron, Kevin J. Filipski, Jana Polivkova, Matthew S. Dowling, Andre Shavnya, Gary Erik Aspnes, David Christopher Ebner, Allan R. Reyes, Qifang Li, Michael Herr, Jun Xiao, Jessica Ward, Shawn Cabral, Heather Eng, Sophie Y. Lavergne, Ravi G. Kurumbail, Jane M. Withka, Samit Kumar Bhattacharya, Dilinie P. Fernando, Meihua Tu, Edward L. Conn, Bo Feng, Janice A. Brown, Daniel W. Kung, Francis Rajamohan, Esther C.Y. Lee, Russell A. Miller, Emily Cokorinos, Christopher T. Salatto, Nicole Caspers, Nathan E. Genung, Jane Panteleev, Benjamin A. Thuma, Matthew F. Calabrese, Sumathy Mathialagan, Aaron C. Smith, Kris A. Borzilleri, David J. Edmonds, Amit S. Kalgutkar

المصدر: Journal of medicinal chemistry. 61(6)

مصطلحات موضوعية: 0301 basic medicine, Adenosine monophosphate, Male, Models, Molecular, Indoles, Organic anion transporter 1, Glucuronidation, Enzyme Activators, Pharmacology, AMP-Activated Protein Kinases, Organic Anion Transporters, Sodium-Independent, Kidney, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Animals, Humans, Rats, Wistar, Protein kinase A, biology, AMPK, Adenosine, Rats, Enzyme Activation, 030104 developmental biology, chemistry, Intestinal Absorption, Renal physiology, biology.protein, Molecular Medicine, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ccac15ee02a34e6adc23a5d238341dTest
https://pubmed.ncbi.nlm.nih.gov/29466005Test

المؤلفون: Heather Eng, John Litchfield, William S. Denney, Esther C.Y. Lee, Theunis C. Goosen, Karen Atkinson, Raman Sharma, Jeffrey A. Pfefferkorn, Deepak Dalvie, John C. Pettersen, Li Di, Amit S. Kalgutkar, Neeta B. Amin

المصدر: Drug Metabolism and Disposition. 42:1926-1939

مصطلحات موضوعية: Drug, medicine.medical_specialty, CYP3A, media_common.quotation_subject, Metabolite, Enzyme Activators, Pharmaceutical Science, Oxidative phosphorylation, Pharmacology, Biology, Beagle, Ames test, chemistry.chemical_compound, Dogs, Internal medicine, Glucokinase, medicine, Animals, Humans, IC50, Benzofurans, media_common, EC50, Rats, Pyrimidines, Endocrinology, chemistry, Area Under Curve, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7100b26922e65b60ec5cf194776dacffTest
https://doi.org/10.1124/dmd.114.060087Test

المؤلفون: Steven B. Coffey, Joel T. Arcari, Paula M. Loria, Esther C.Y. Lee, Kentaro Futatsugi, Raman Sharma, David R. Derksen, Amit S. Kalgutkar, Kevin B. Bahnck

المصدر: Bioorganicmedicinal chemistry letters. 26(11)

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, medicine, Humans, Prostaglandin E2, Molecular Biology, G protein-coupled receptor, Indazole, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Small molecule, Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, Lipophilic efficiency, Receptors, Prostaglandin E, EP3 Subtype, Molecular Medicine, lipids (amino acids, peptides, and proteins), Antagonism, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bad0904c90a0e00a80a1a42da09da66Test
https://pubmed.ncbi.nlm.nih.gov/27107947Test

المؤلفون: Beijing Tan, Stephen W. Wright, Karen Atkinson, Janice A. Brown, Angel Guzman-Perez, Kevin J. Filipski, John Litchfield, Mary Theresa Didiuk, Esther C.Y. Lee, Christopher T. Salatto, Jian-Cheng Li, David Christopher Ebner, Meihua Tu, Jeffrey A. Pfefferkorn, Jianwei Bian, Christian Perreault, Matthew F. Sammons, Benjamin D. Stevens

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:415-420

مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Ether, Biochemistry, Glucagon, chemistry.chemical_compound, Dogs, Pharmacokinetics, Internal medicine, Diabetes mellitus, Drug Discovery, Diabetes Mellitus, Receptors, Glucagon, medicine, Animals, Humans, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Organic Chemistry, Temperature, medicine.disease, Rats, Molecular Weight, Kinetics, Dose–response relationship, Glucose, Endocrinology, Models, Chemical, chemistry, Drug Design, Lipophilicity, Pyrazoles, Molecular Medicine, Glucagon receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e84026e85448c47076ca75b76b5fd9Test
https://doi.org/10.1016/j.bmcl.2011.10.113Test

المؤلفون: Matthew F. Sammons, Esther C.Y. Lee

المصدر: Bioorganicmedicinal chemistry letters. 25(19)

مصطلحات موضوعية: medicine.medical_specialty, Hepatic glucose, Clinical Biochemistry, Pharmaceutical Science, Type 2 diabetes, Pharmacology, Biochemistry, Glucagon, Small Molecule Libraries, Structure-Activity Relationship, Internal medicine, Drug Discovery, medicine, Receptors, Glucagon, Endocrine system, Animals, Humans, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Glucagon secretion, medicine.disease, Small molecule, Endocrinology, Molecular Medicine, Glucagon receptor, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8e78d0996dfe9d8a57300c80517e3dTest
https://pubmed.ncbi.nlm.nih.gov/26271588Test

المؤلفون: Esther C.Y. Lee, Philip A. Carpino

المصدر: Pharmaceutical patent analyst. 4(2)

مصطلحات موضوعية: Agonist, medicine.drug_class, General Medicine, Pharmacology, Biology, medicine.disease, Obesity, Melanocortin 4 receptor, Clinical trial, Patents as Topic, Patent analysis, medicine.anatomical_structure, Orally active, Central melanocortin system, medicine, Animals, Humans, Receptor, Melanocortin, Type 4, Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0997bbfa53328639a2efe0c1a5ae6eTest
https://pubmed.ncbi.nlm.nih.gov/25853469Test

المؤلفون: John Litchfield, Matthew F. Sammons, Gary Erik Aspnes, David Christopher Ebner, Janice A. Brown, Amit S. Kalgutkar, Stephen W. Wright, Jeffrey A. Pfefferkorn, Kevin J. Filipski, Meihua Tu, Angel Guzman-Perez, Esther C.Y. Lee, Raman Sharma, Jianwei Bian, Benjamin D. Stevens, Karen Atkinson, Christian Perreault, Mary Theresa Didiuk

المصدر: Bioorganicmedicinal chemistry letters. 24(3)

مصطلحات موضوعية: Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Administration, Oral, Ligands, Biochemistry, Dogs, In vivo, Drug Discovery, Receptors, Glucagon, Animals, Rats, Wistar, Molecular Biology, Glucagon-like peptide 1 receptor, Cells, Cultured, Ligand efficiency, biology, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Cytochrome P450, Stereoisomerism, Small molecule, Rats, Pyrimidines, Benzamides, biology.protein, Molecular Medicine, Administration, Intravenous, Glucagon receptor, Oxidation-Reduction, Drug metabolism, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a543d4ed0d1bf19ccf1765d962b6420Test
https://pubmed.ncbi.nlm.nih.gov/24418771Test