التفاصيل البيبلوغرافية
| العنوان: |
Association between the nuclear to cytoplasmic ratio of p27 and the efficacy of adjuvant polychemotherapy in early breast cancer |
| المؤلفون: |
Andre, Fabrice, Conforti, Rosa, Arnedos, Monica, Berrada, Narjiss, Delaloge, Suzette, Spielmann, Marc, Moeder, Christopher C.B., Rimm, David D.L., Mauguen, Audrey, Michiels, Stefan, Tomasic, Gorana, Esteva, Francisco F.J. |
| المصدر: |
Annals of oncology, 23 (8 |
| سنة النشر: |
2012 |
| المجموعة: |
DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: |
Hématologie, Cancérologie, Anthracycline-based chemotherapy, Early breast cancer, P27 expression |
| الوصف: |
Background: The purpose of this study was to evaluate the prognostic and predictive value of p27 expression in patients with early breast cancer. Patients and methods: Quantitative immunofluorescence assays for p27 were done on a tissue microarray that included 823 samples from patients randomized between anthracycline-based chemotherapy and no chemotherapy. Quantification of p27 was done using the AQUA® system (HistoRx, Inc. Branford, CT). Both p27 nuclear expression and the nuclear to cytoplasmic ratio were assessed. Results: Nuclear p27 expression was not predictive for the efficacy of anthracycline-based chemotherapy [adjusted P = 0.18 for disease-free survival (DFS)] nor prognostic [95% confidence interval (CI) 0.99-1.01, P = 0.49]. However, p27 nuclear/cytoplasmic ratio was predictive for the efficacy of adjuvant chemotherapy (adjusted P = 0.016 DFS). The adjusted hazard ratio (HR) for relapse associated with adjuvant chemotherapy was 0.56 (95% CI 0.37-0.84, P = 0.005) and 1.06 (95% CI 0.76-1.47, P = 0.74) for patients with high and low nuclear/cytoplasmic ratio, respectively. p27 N/C ratio was prognostic in patients treated with chemotherapy (HR for relapse or death for a 1 unit increase in p27 N/C ratio was 0.30, 95% CI 0.12-0.77) but not in the untreated arm (HR for relapse or death was 1.27, 95% CI 0.58-2.8). Conclusions: This study did not confirm the role of p27 nuclear expression as a prognostic parameter. However, the p27 nuclear/cytoplasmic ratio was predictive in patients treated with anthracycline-based chemotherapy. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
1 full-text file(s): application/pdf |
| اللغة: |
English |
| العلاقة: |
uri/info:doi/10.1093/annonc/mdr569; uri/info:pmid/22241898; uri/info:scp/84864917378; https://dipot.ulb.ac.be/dspace/bitstream/2013/195912/3/doi_179539.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/195912Test |
| الإتاحة: |
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/195912Test |
| رقم الانضمام: |
edsbas.92FF203E |
| قاعدة البيانات: |
BASE |
