Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD
| العنوان: | Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD |
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| المؤلفون: | Hideo Suzuki, Fumihiko Uchida, Kiyoji Tanaka, Takeji Sakae, Sechang Oh, Bokun Kim, Takehiko Tsujimoto, Junichi Shoda, Seiichiro Iizumi, Tomonori Isobe |
| المصدر: | JHEP Reports JHEP Reports, Vol 3, Iss 3, Pp 100253-(2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | FGF21, Adipose tissue, RC799-869, AST, aspartate aminotransferase, WFA+-M2BP, Wisteria floribunda agglutinin-positive human Mac-2 binding protein, NEFAs, non-esterified fatty acids, GGT, gamma-glutamyl transpeptidase, Weight loss, WC, waist circumference, Immunology and Allergy, Medicine, HO1, heme oxygenase 1, GPx, glutathione peroxidase, TNF-α, tumour necrosis factor alpha, Fatty liver, Gastroenterology, VAT, visceral adipose tissue, Diseases of the digestive system. Gastroenterology, TEI, total energy intake, TG, triglycerides, GCLM, glutamate-cysteine ligase modifier subunit, Esub, exercise (subset for which biological samples were available) group, Esmall, small amount of exercise group, Wtotal, weight-loss group, TBARS, thiobarbituric acid-reactive substances, BDNF, brain-derived neurotrophic factor, LPS, lipopolysaccharide, CAP, controlled attenuation parameter, NF-Score, NAFLD fibrosis score, medicine.symptom, Research Article, FAST-Score, FibroScan-AST score, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, LSM, liver stiffness measured using transient elastography, Hepatokine, FGF-21, fibroblast growth factor-21, Dietary restriction, NASH, non-alcoholic steatohepatitis, Elarge, large amount of exercise group, MVPA, moderate-to-vigorous intensity physical activity, SPARC, secreted protein acidic and rich in cysteine, NQO1, NAD(P)H quinone oxidoreductase, Myokine, ALT, alanine aminotransferase, Internal medicine, Internal Medicine, Aerobic exercise, Liver fat, Etotal, exercise group, FPG, fasting plasma glucose, KC, Kupffer cells, Se-P, selenoprotein-P, PBMCs, peripheral blood mononuclear cells, Nuclear factor-erythroid 2-related factor 2, Hepatology, Adiponectin, business.industry, Nrf2, nuclear factor E2-related factor 2, Wsub, weight-loss (subset for which biological samples were available) group, medicine.disease, HOMA-IR, homeostasis model assessment-insulin resistance, Regimen, Endocrinology, mnSOD, manganese superoxide dismutase, ANGPTL6, angiopoietin-like 6, Liver stiffness, business, GCLC, glutamate-cysteine ligase catalytic subunit |
| الوصف: | Summary Background & Aims A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exercise on individual tissues (liver, adipose tissue, and skeletal muscle) were retrospectively studied. Methods Data from Japanese obese men with NAFLD in a 3-month exercise regimen were analysed and compared with those in a 3-month dietary restriction program designed to achieve weight loss. The underlying mechanism was studied in a smaller subcohort. Results Independent of the effect of weight loss, the exercise regimen reduced liver steatosis by 9.5% and liver stiffness by 6.8% per 1% weight loss, and resulted in a 16.4% reduction in FibroScan-AST score. Improvements in these hepatic parameters were closely associated with anthropometric changes (reduction in adipose tissue and preservation of muscle mass), increases in muscle strength (+11.6%), reductions in inflammation and oxidative stress (ferritin: -22.3% and thiobarbituric acid: -12.3%), and changes in organokine concentrations (selenoprotein-P: -11.2%, follistatin: +17.1%, adiponectin: +8.9%, and myostatin: -21.6%) during the exercise regimen. Moreover, the expression of target genes of the transcription factor Nrf2, an oxidative stress sensor, was higher in monocytes, suggesting that Nrf2 is activated. Large amounts of high-intensity exercise were effective at further reducing liver steatosis and potentiating improvements in pathophysiological parameters (liver enzyme activities and organokine profiles). Conclusions The weight-loss-independent benefits of exercise include anti-steatotic and anti-stiffness effects in the livers of patients with NAFLD. These benefits seem to be acquired through the modification of inter-organ crosstalk, which is characterised by improvements in organokine imbalance and reductions in inflammation and oxidative stress. Lay summary We investigated the effects of exercise on non-alcoholic fatty liver disease (NAFLD) that were not related to weight loss. We found that exercise had considerable weight-loss-independent benefits for the liver through a number of mechanisms. This suggests that exercise is important for NAFLD patients, regardless of whether they lose weight. Graphical abstract Highlights • Exercise has effects on liver steatosis and stiffness, independent of weight loss. • Exercise maintains muscle mass and alters the secretion of organokines. • Exercise increases the phagocytic capacity of Kupffer cells and activates Nrf2. • Exercise, especially vigorous exercise, should be used aggressively to manage non-alcoholic fatty liver disease (NAFLD). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2589-5559 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d799758e6591ac117326fd2a92b672f8Test https://tsukuba.repo.nii.ac.jp/records/2004615Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d799758e6591ac117326fd2a92b672f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25895559 |
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