المؤلفون: Ladislav Prener, Ondřej Baszczyňski, Martin M. Kaiser, Martin Dračínský, George Stepan, Yu-Jen Lee, Boris Brumshtein, Helen Yu, Petr Jansa, Eric B. Lansdon, Zlatko Janeba

المصدر: Journal of Medicinal Chemistry. 66:1761-1777

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::39ab39534a1970a487d788dabe69090cTest
https://doi.org/10.1021/acs.jmedchem.2c01574Test

المؤلفون: Magdeleine Hung, E. John Tokarsky, Leanna Lagpacan, Lijun Zhang, Zucai Suo, Eric B. Lansdon

المصدر: Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)

مصطلحات موضوعية: 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, lcsh:Biology (General), Medicine (miscellaneous), virus diseases, General Agricultural and Biological Sciences, lcsh:QH301-705.5, 030217 neurology & neurosurgery, General Biochemistry, Genetics and Molecular Biology, 3. Good health, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aa56ad3815dc5f8fe74f5a4b06db73Test
http://link.springer.com/article/10.1038/s42003-019-0706-xTest

المؤلفون: Wanchi Fung, Kobayashi Tetsuya, Anita Niedziela-Majka, Bob Jiang, Kim Jordan, Saritha Kusam, David G. Breckenridge, Hai Yang, Britton Kenneth Corkey, Kristyna Elbel, Chin Tay, Elaine Kan, Sammy Metobo, David Sperandio, Du Jinfa, Richard M. Neve, Sophia L. Shevick, Eric B. Lansdon, Kerim Babaoglu, Gregory Chin, Heather Webb, Debi Jin, Annapurna Sapre, Vangelis Aktoudianakis, Latesh Lad, Jamie Bates, Xiaowu Chen, Jeff Zablocki, Gene Eisenberg, Nate Larson, Richard L. Mackman, Martinez Ruben, Magdeleine Hung, Zachary Newby, Mish Michael R

المصدر: Bioorganic & Medicinal Chemistry. 27:457-469

مصطلحات موضوعية: Benzimidazole, BRD4, Cell Survival, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Protein Domains, Cell Line, Tumor, Drug Discovery, Animals, Humans, Potency, Tumor growth, Epigenetics, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Aryl, Organic Chemistry, Isoxazoles, Neoplasms, Experimental, Bioavailability, Bromodomain, chemistry, Molecular Medicine, Benzimidazoles, Multiple Myeloma, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32393d33e86182931fa91168f5389d3cTest
https://doi.org/10.1016/j.bmc.2018.11.020Test

المؤلفون: Eric B. Lansdon, Helen Yu, Kropf Jeffrey E, Peter A. Blomgren, Jennifer R. Lo, Guoju Geng, Kevin S. Currie, Aaron C. Schmitt, Jayaraman Chandrasekhar, Chris Pohlmeyer, Scott A. Mitchell, Seung H. Lee, Wanchi Fung, Sarah Wise, Jin-Ming Xiong, Zhongdong Zhao, Randall Mark Jones, Kimberly Suekawa-Pirrone, Julie Di Paolo, Bernard P. Murray, Carmen Ip, Jianjun Xu

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Cell type, Systemic lupus erythematosus, 010405 organic chemistry, business.industry, Organic Chemistry, Regulator, Syk, Drug interaction, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Immune system, Pharmacokinetics, Drug Discovery, medicine, Cancer research, Once daily, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a219ff1dd97e346313a9eebe517807Test
https://pubmed.ncbi.nlm.nih.gov/32292557Test

المؤلفون: Julie Farand, Jeffrey E. Kropf, Peter Blomgren, Jianjun Xu, Aaron C. Schmitt, Zachary E. Newby, Ting Wang, Eisuke Murakami, Ona Barauskas, Jawahar Sudhamsu, Joy Y. Feng, Anita Niedziela-Majka, Brian E. Schultz, Karen Schwartz, Serge Viatchenko-Karpinski, Dmytro Kornyeyev, Adam Kashishian, Peidong Fan, Xiaowu Chen, Eric B. Lansdon, Michael O. Ports, Kevin S. Currie, William J. Watkins, Gregory T. Notte

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8664fe5cf60201d9c5d872c2fbdf25Test
https://europepmc.org/articles/PMC7074220Test/

المؤلفون: David G. Breckenridge, Laurie A. Castonguay, Giuseppe A. Papalia, Swetha Pendem, Shawn S. Badal, Ford Hinojosa-Kirschenbaum, Gregory T. Notte, Sarah Wise, Michael V. Lee, Keith A. Koch, Agnes B. Fogo, Dorothy French, Britton Kenneth Corkey, Frank Y. Ma, Brian E. Schultz, Eric B. Lansdon, Melanie H. Wong, David J. Nikolic-Paterson, Tareq M Al-Tuhaifi, Theodore Sullivan, Michael Graupe, Haichun Yang, Erik Huntzicker, Grant R. Budas, John T. Liles

المصدر: Journal of Clinical Investigation. 128:4485-4500

مصطلحات موضوعية: Male, 0301 basic medicine, Nephrology, medicine.medical_specialty, MAP Kinase Signaling System, Kidney Glomerulus, Renal function, MAP Kinase Kinase Kinase 5, Rats, Sprague-Dawley, Mice, Random Allocation, 03 medical and health sciences, Fibrosis, Internal medicine, medicine, Animals, Humans, Diabetic Nephropathies, ASK1, Protein Kinase Inhibitors, Mice, Knockout, Serine/threonine-specific protein kinase, Kidney, business.industry, Glomerulosclerosis, General Medicine, Fibroblasts, medicine.disease, Oxidative Stress, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Female, business, Research Article, Kidney disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b037ace289b522c4f72e5fa892d048Test
https://doi.org/10.1172/jci99768Test

المؤلفون: J. Andrew Whitney, Kevin S. Currie, Deborah Maclin, James Barbosa, Kropf Jeffrey E, Ann Marie Rossi, Eric B. Lansdon, Jennifer Macaluso, Scott A. Mitchell, Hong Rong, Tony Lee, Jianjun Xu, Steve Gallion, Patricia Maciejewski, Julie Di Paolo, Peter A. Blomgren, Zhongdong Zhao

المصدر: Journal of Medicinal Chemistry. 57:3856-3873

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Indazoles, Magnetic Resonance Spectroscopy, Administration, Oral, Syk, Pharmacology, Fostamatinib, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Adverse effect, Protein Kinase Inhibitors, Cells, Cultured, Chemistry, Drug discovery, hemic and immune systems, Protein-Tyrosine Kinases, Prodrug, Highly selective, Rats, Pyrazines, Molecular Medicine, Clinical evaluation, Spleen, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b4e26bd97c65595d3ff3afda0fbb23Test
https://doi.org/10.1021/jm500228aTest

المؤلفون: George Stepan, Ondřej Baszczyňski, Eric B. Lansdon, Petr Šimon, David Šaman, Eric Hu, Zlatko Janeba, Petr Jansa

المصدر: European journal of medicinal chemistry. 122

مصطلحات موضوعية: 0301 basic medicine, Pyrimidine, Stereochemistry, Protein Conformation, Compound 17, Human immunodeficiency virus (HIV), medicine.disease_cause, Ring (chemistry), 01 natural sciences, Nucleoside Reverse Transcriptase Inhibitor, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, medicine, Moiety, Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, HIV Reverse Transcriptase, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Pyrimidines, Drug Design, HIV-1, Reverse Transcriptase Inhibitors, Linker, Derivative (chemistry)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16685fc8fa89ddc4f5d64b8cd03f552fTest
https://pubmed.ncbi.nlm.nih.gov/27371922Test

المؤلفون: Kerim Babaoglu, Eric B. Lansdon, Evguenia S. Svarovskaia, Laurence T. Rimsky, Veerle Van Eygen, Gaston Picchio, Michael D. Miller, Kirsten L. White, Rima Kulkarni

المصدر: JAIDS Journal of Acquired Immune Deficiency Syndromes. 59:47-54

مصطلحات موضوعية: Gene Expression Regulation, Viral, Models, Molecular, Anti-HIV Agents, Protein Conformation, Mutant, Drug resistance, Biology, Virus Replication, Emtricitabine, Gene Expression Regulation, Enzymologic, chemistry.chemical_compound, immune system diseases, Drug Resistance, Viral, Nitriles, medicine, Humans, Pharmacology (medical), Rilpivirine, Wild type, virus diseases, Resistance mutation, Virology, HIV Reverse Transcriptase, Reverse transcriptase, Pyrimidines, Infectious Diseases, chemistry, Viral replication, Mutation, HIV-1, RNA, Viral, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1678a33b8dd0392aa46063257165be2Test
https://doi.org/10.1097/qai.0b013e31823aca74Test

المؤلفون: Eric B. Lansdon, Constantine G. Boojamra, Adrian S. Ray, Richard L. Mackman, Katherine M. Brendza, Magdeleine Hung, S. Swaminathan, Dharmaraj Samuel, Xiaohong Liu, Leanna Lagpacan, Tomas Cihlar, Mary E. McGrath, Kirsten L. White

المصدر: Journal of Molecular Biology. 397:967-978

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Mutation, Missense, Biology, Crystallography, X-Ray, chemistry.chemical_compound, Protein structure, Structural Biology, Deoxyadenosine triphosphate, Drug Resistance, Viral, Ribose, Nucleotide, Molecular Biology, chemistry.chemical_classification, Guanosine, DNA, HIV Reverse Transcriptase, Reverse transcriptase, Protein Structure, Tertiary, chemistry, Deoxyadenosine monophosphate, Biochemistry, Reverse Transcriptase Inhibitors, Nucleoside, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b39df2449b0f3e4176a11822859776Test
https://doi.org/10.1016/j.jmb.2010.02.019Test