دورية أكاديمية
Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
| العنوان: | Use cases, best practice and reporting standards for metabolomics in regulatory toxicology |
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| المؤلفون: | Viant, Mark R., Ebbels, Timothy M. D., Beger, Richard D., Ekman, Drew R., Epps, David J. T., Kamp, Hennicke, Leonards, Pim E. G., Loizou, George D., MacRae, James I., van Ravenzwaay, Bennard, Rocca-Serra, Philippe, Salek, Reza M., Walk, Tilmann, Weber, Ralf J. M. |
| المساهمون: | European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) http://www.ecetoc.orgTest/ |
| المصدر: | Nature Communications ; volume 10, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-019-10900-y |
| الإتاحة: | https://doi.org/10.1038/s41467-019-10900-yTest https://www.nature.com/articles/s41467-019-10900-y.pdfTest https://www.nature.com/articles/s41467-019-10900-yTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.54F2C3BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-019-10900-y |
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