دورية أكاديمية
Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Plasmodium falciparum dhfr-dhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon
| العنوان: | Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Plasmodium falciparum dhfr-dhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon |
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| المؤلفون: | Eboumbou Moukoko, Carole Else, Kojom Foko, Loick Pradel, Ayina, Angèle, Tornyigah, Bernard, Epote, Annie Rachel, Penda, Ida Calixte, Epee Eboumbou, Patricia, Ebong, Serge Bruno, Texier, Gaetan, Nsango, Sandrine Eveline, Ayong, Lawrence, Tuikue Ndam, Nicaise, Same Ekobo, Albert |
| المساهمون: | Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), ICMR-National Institute of Malaria Research, Dwarka, New Delhi, Pharmaceutical Sciences Department, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, University of Ghana, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Université de Douala, Animal Organisms Biology and Physiology Department, Faculty of Sciences, The University of Douala, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA), Service de Santé des Armées |
| المصدر: | ISSN: 2076-0817 ; Pathogens ; https://amu.hal.science/hal-04148697Test ; Pathogens, 2023, 12 (6), pp.844. ⟨10.3390/pathogens12060844⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | malaria infection, IPTp-SP, pregnant women, effectiveness, dhfr, dhps, k13 mutations, Cameroon, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; Intermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine (IPTp-SP) is a key component in the malaria control strategy implemented in Africa. The aim of this study was to determine IPTp-SP adherence and coverage, and the impact on maternal infection and birth outcomes in the context of widespread SP resistance in the city of Douala, Cameroon. Clinical and demographic information were documented among 888 pregnant women attending 3 health facilities, from the antenatal care visit to delivery. Positive samples were genotyped for P. falciparum gene (dhfr, dhps, and k13) mutations. The overall IPTp-SP coverage (≥three doses) was 17.5%, and 5.1% received no dose. P. falciparum prevalence was 16%, with a predominance of submicroscopic infections (89.3%). Malaria infection was significantly associated with locality and history of malaria, and it was reduced among women using indoor residual spraying. Optimal doses of IPTp-SP were significantly associated with reduced infection among newborns and women (secundiparous and multiparous), but there was no impact of IPTp-SP on the newborn bodyweight. Pfdhfr-Pfdhps quintuple mutants were over-represented (IRNI-FGKAA, IRNI-AGKAA), and sextuple mutants (IRNI-AGKAS, IRNI-FGEAA, IRNI-AGKGS) were also reported. The Pfk13 gene mutations associated with artemisinin resistance were not detected. This study highlights the role of ANC in achieving optimal SP coverage in pregnant women, the mitigated impact of IPTp-SP on malaria outcomes, and the high prevalence of multiple SP-resistant P. falciparum parasites in the city of Douala that could compromise the efficacy of IPTp-SP. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04148697; https://amu.hal.science/hal-04148697Test; https://amu.hal.science/hal-04148697/documentTest; https://amu.hal.science/hal-04148697/file/pathogens-12-00844-v3.pdfTest |
| DOI: | 10.3390/pathogens12060844 |
| الإتاحة: | https://doi.org/10.3390/pathogens12060844Test https://amu.hal.science/hal-04148697Test https://amu.hal.science/hal-04148697/documentTest https://amu.hal.science/hal-04148697/file/pathogens-12-00844-v3.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8203FFD0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pathogens12060844 |
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