دورية أكاديمية
High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma
| العنوان: | High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma |
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| المؤلفون: | Eichenauer, Till, Simmendinger, Luca, Fraune, Christoph, Mandelkow, Tim, Blessin, Niclas C., Kluth, Martina, Hube-Magg, Claudia, Möller, Katharina, Clauditz, Till, Weidemann, Sören, Dahlem, Roland, Fisch, Margit, Riechardt, Silke, Simon, Ronald, Sauter, Guido, Büscheck, Franziska, Rink, Michael |
| المصدر: | http://lobid.org/resources/99370672102306441Test#!, 39(2):481-490. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Gene Expression Regulation, Neoplastic [MeSH], CD8, Aged, 80 and over [MeSH], Aged [MeSH], EZH2, Humans [MeSH], Kidney Neoplasms/chemistry [MeSH], Carcinoma, Renal Cell/chemistry [MeSH], Kidney Neoplasms/pathology [MeSH], Middle Aged [MeSH], Kidney Neoplasms/blood [MeSH], Cohort Studies [MeSH], Original Article, Renal cell carcinoma, Kidney Neoplasms/genetics [MeSH], Tissue microarrays, Enhancer of Zeste Homolog 2 Protein/analysis [MeSH], Enhancer of Zeste Homolog 2 Protein/biosynthesis [MeSH], Phenotype [MeSH], Renal Cell/blood [MeSH], Renal Cell/pathology [MeSH], CD8-Positive T-Lymphocytes [MeSH], Renal Cell/genetics [MeSH] |
| الوصف: | Purpose!#!Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity.!##!Methods!#!To investigate whether the prognostic role of EZH2 might be driven by a modified immune environment, more than 1800 RCCs were analyzed in a tissue microarray for EZH2 expression and CD8 positive lymphocytes were quantitated by automated digital imaging.!##!Results!#!EZH2 positivity was found in 75.2% of 1603 interpretable tumors. In clear cell RCC, high EZH2 expression was significantly linked to high ISUP, Furmann, and Thoenes grade (p < 0.0001 each), advanced stage (p < 0.0001), nodal (p = 0.0190) and distant metastasis (p < 0.0001) as well as shortened overall (p < 0.0027) and recurrence free survival (p < 0.0001). The density of CD8+ cells varied from 0 to 5048 cells/mm!##!Conclusion!#!Our data support a striking prognostic role of both EZH2 expression and the density of CD8+ cells in RCC. The tight relationship of EZH2 expression and CD8+ cell counts in RCC is consistent with models suggesting that EZH2 overexpression can be caused by high lymphocyte content in certain tumor types. Such a mechanism could explain the unique finding of high lymphocyte counts driving poor prognosis in RCC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6466824Test; https://doi.org/10.1007/s00345-020-03200-4Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910252Test/ |
| DOI: | 10.1007/s00345-020-03200-4 |
| الإتاحة: | https://doi.org/10.1007/s00345-020-03200-4Test https://repository.publisso.de/resource/frl:6466824Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910252Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.2AA2B8BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00345-020-03200-4 |
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