New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity
| العنوان: | New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity |
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| المؤلفون: | Ling Zhang, Ze-Jun Dong, Ji-Kai Liu, Fang Wang, Yang Wang, Zheng-Hui Li |
| المصدر: | Natural Products and Bioprospecting |
| بيانات النشر: | Springer Berlin Heidelberg, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Stereochemistry, Engleromycenol, Plant Science, Fungus, Toxicology, Inhibitory postsynaptic potential, Bioinformatics, Biochemistry, Analytical Chemistry, Rosenonolactone, chemistry.chemical_compound, Engleromyces, Cholesterylester transfer protein, CETP, Bioorganic chemistry, Pharmacology, biology, Engleromyces goetzii, Organic Chemistry, Engleromycenolic acid A, Engleromycenolic acid B, Cetp inhibition, biology.organism_classification, chemistry, biology.protein, Original Article, Diterpene, Food Science |
| الوصف: | One new cleistanthane-type diterpene named engleromycenolic acid A (1), one new rosane-type diterpene named engleromycenolic acid B (2) and one new natural rosane-type diterpene, engleromycenol (3), along with three known rosane-type diterpenes, rosololactone (4), rosenonolactone (5) and 7-deoxyrosenonolactone (6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1–6 were evaluated for their cholesterol ester transfer protein (CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds. Graphical Abstract Electronic supplementary material The online version of this article (doi:10.1007/s13659-015-0055-5) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 2192-2209 2192-2195 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763b3246d13592325c5b1b940a71b671Test http://europepmc.org/articles/PMC4402584Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....763b3246d13592325c5b1b940a71b671 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21922209 21922195 |
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