دورية أكاديمية
The neo-open reading frame peptides that comprise the tumor framome are a rich source of neoantigens for cancer immunotherapy
| العنوان: | The neo-open reading frame peptides that comprise the tumor framome are a rich source of neoantigens for cancer immunotherapy |
|---|---|
| المؤلفون: | Martin, Michael V., Aguilar-Rosas, Salvador, Franke, Katka, Pieterse, Mark, van Langelaar, Jamie, Schreurs, Renee Rce, Bijlsma, Maarten F., Besselink, Marc G., Koster, Jan, Timens, Wim, Khasraw, Mustafa, Ashley, David M., Keir, Stephen T., Ottensmeier, Christian H., King, Emma V., Verheij, Joanne, Waasdorp, Cynthia, Valk, Peter J.M., Engels, Sem Ag, Oostenbach, Ellen, van Dinter, Jip T., Hofman, Damon A., Mok, Juk Yee, van Esch, Wim J.E., Wilmink, Hanneke, Monkhorst, Kim, Verheul, Henk M.W., Poel, Dennis, Hiltermann, T. Jeroen N., van Kempen, Léon, Groen, Harry J.M., Aerts, Joachim G.J.V., van Heesch, Sebastiaan, Lowenberg, Bob, Plasterk, Ronald, Kloosterman, Wigard P. |
| المصدر: | Cancer immunology research ; 2326-6074 |
| سنة النشر: | 2024 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Human medicine |
| الوصف: | Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate cancer whole genome and long-read transcript sequencing to identify the collection of novel open reading frame peptides (NOPs) expressed in tumors, termed the framome. NOPs represent tumor-specific peptides that are different from wild-type proteins and may be strongly immunogenic. We describe an uncharacterized class of hidden NOPs, which derive from structural genomic variants involving an upstream protein coding gene driving expression and translation of non-coding regions of the genome downstream of a rearrangement breakpoint. NOPs represent a vast amount of possible neoantigens particularly in tumors with many (complex) structural genomic variants and a low number of missense mutations. We show that NOPs are immunogenic and epitopes derived from NOPs can bind to MHC class I molecules. Finally, we provide evidence for the presence of memory T-cells specific for hidden NOPs in lung cancer patient peripheral blood. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| الإتاحة: | https://doi.org/10.1158/2326-6066.CIR-23-0158Test https://hdl.handle.net/10067/2050190151162165141Test https://repository.uantwerpen.be/docstore/d:irua:22829Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.42FE39C4 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |