المؤلفون: Chauca Strand, Gabriella, Johansson, Naimi, Jakobsson, Niklas, Professor, 1981, Bonander, Carl, 1988, Svensson, Mikael

المصدر: Clinical drug investigation. 43(8):621-633

مصطلحات موضوعية: renal-cell carcinoma, european medicines agency, early breast-cancer, clinical benefit, lung-cancer, phase-III, end-points, open-label, everolimus, outcomes, Economics, Nationalekonomi

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-96400Test
https://doi.org/10.1007/s40261-023-01285-4Test
https://kau.diva-portal.org/smash/get/diva2:1788854/FULLTEXT02.pdfTest

المؤلفون: Yeju Kim, Ceyhun Bereketoglu, Onur Sercinoglu, Ajay Pradhan

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Developmental Biology, Science Policy, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, threaten human health, several signaling pathways, molecular docking simulations, including oxidative stress, different cell lines, several end points, mixture group acted, higher effect displayed, signaling mechanisms pyraclostrobin, mixture group, cell cycle, spectrum fungicides, silico analysis, reporter assays, nfκb activators, negative effects, mitochondrial function, including mortality, genes involved, first time, environmental fate

العلاقة: https://figshare.com/articles/journal_contribution/In_Vitro_In_Vivo_and_In_Silico_Analysis_of_Pyraclostrobin_and_Cyprodinil_and_Their_Mixture_Reveal_New_Targets_and_Signaling_Mechanisms/25310761Test

الإتاحة: https://doi.org/10.1021/acs.chemrestox.3c00371.s001Test
https://figshare.com/articles/journal_contribution/In_Vitro_In_Vivo_and_In_Silico_Analysis_of_Pyraclostrobin_and_Cyprodinil_and_Their_Mixture_Reveal_New_Targets_and_Signaling_Mechanisms/25310761Test

المؤلفون: Emile P. Chen, Shayoni Dutta, Ming-Hsun Ho, Michael P. DeMartino

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Immunology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, screening criteria must, machine learning approach, adme space early, preclinical efficacy models, achieve therapeutic efficacy, pk end points, define pk drivers, pd relationships presented, based virtual pk, based virtual exploration, early drug discovery, specific pk drivers, identify target pharmacology, pd exploration, driving efficacy, based analysis, multiple pharmacology, downstream pharmacology, corresponding pharmacology, results demonstrate

العلاقة: https://figshare.com/articles/journal_contribution/Model-Based_Virtual_PK_PD_Exploration_and_Machine_Learning_Approach_to_Define_PK_Drivers_in_Early_Drug_Discovery/25249732Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c02169.s001Test
https://figshare.com/articles/journal_contribution/Model-Based_Virtual_PK_PD_Exploration_and_Machine_Learning_Approach_to_Define_PK_Drivers_in_Early_Drug_Discovery/25249732Test

المؤلفون: Thomas Sol Dourdin, Killian Guyomard, Manuella Rabiller, Nina Houssais, Alexandre Cormier, Pauline Le Monier, Rossana Sussarellu, Guillaume Rivière

مصطلحات موضوعية: Genetics, Molecular Biology, Ecology, Developmental Biology, Inorganic Chemistry, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, physiological end points, numerous studies highlighted, nominal sum concentration, field survival rates, environmentally relevant mixture, ancestors ’ gift, alter organisms beyond, term adaptive implications, individual scale level, multigenerational phenotypic effects, induced epigenetic alterations, epigenetic mark implicated, parental early exposure, immunity exhibited f1, clear f0 treatment, multigenerational implications, epigenetic outcomes, molecular level, genes implicated, multigenerational exposure, multigenerational effect, studied invertebrates

العلاقة: https://figshare.com/articles/journal_contribution/Ancestors_Gift_Parental_Early_Exposure_to_the_Environmentally_Realistic_Pesticide_Mixture_Drives_Offspring_Phenotype_in_a_Larger_Extent_Than_Direct_Exposure_in_the_Pacific_Oyster_Crassostrea_gigas/24994501Test

الإتاحة: https://doi.org/10.1021/acs.est.3c08201.s001Test
https://figshare.com/articles/journal_contribution/Ancestors_Gift_Parental_Early_Exposure_to_the_Environmentally_Realistic_Pesticide_Mixture_Drives_Offspring_Phenotype_in_a_Larger_Extent_Than_Direct_Exposure_in_the_Pacific_Oyster_Crassostrea_gigas/24994501Test

المؤلفون: Sara J. Hutton, Samreen Siddiqui, Emily I. Pedersen, Christopher Y. Markgraf, Amelie Segarra, Michelle L. Hladik, Richard E. Connon, Susanne M. Brander

مصطلحات موضوعية: Biochemistry, Genetics, Ecology, Developmental Biology, Inorganic Chemistry, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, sea level rise, mating seasons change, larval inland silversides, global climate change, environmentally relevant concentrations, end points relevant, damaging agricultural crops, different salinity conditions, 10 psu resulted, l ), cyfluthrin, testing behavior, subset assessed, select suite, reduced toxicity, prevent pests, menidia beryllina, insecticide toxicity, increased use, increased temperatures, hypoactive relative, hyperactive relative, higher salinity

العلاقة: https://figshare.com/articles/journal_contribution/Multigenerational_Indirect_Exposure_to_Pyrethroids_Demonstrates_Potential_Compensatory_Response_and_Reduced_Toxicity_at_Higher_Salinity_in_Estuarine_Fish/25058364Test

الإتاحة: https://doi.org/10.1021/acs.est.3c06234.s001Test
https://figshare.com/articles/journal_contribution/Multigenerational_Indirect_Exposure_to_Pyrethroids_Demonstrates_Potential_Compensatory_Response_and_Reduced_Toxicity_at_Higher_Salinity_in_Estuarine_Fish/25058364Test

المؤلفون: Pechhacker, Monika K Grudzinska, Jacobson, Samuel G, Drack, Arlene V, Di Scipio, Matteo, Strubbe, Ine, Pfeifer, Wanda, Duncan, Jacque L, Dollfus, Helene, Goetz, Nathalie, Muller, Jean, Vincent, Andrea L, Aleman, Tomas S, Tumber, Anupreet, Van Cauwenbergh, Caroline, De Baere, Elfride, Bedoukian, Emma, Leroy, Bart P, Maynes, Jason T, Munier, Francis L, Tavares, Erika, Saleh, Eman, Vincent, Ajoy, Heon, Elise

المصدر: Investigative Ophthalmology & Visual Science. 62(15)

مصطلحات موضوعية: Rare Diseases, Neurosciences, Eye Disease and Disorders of Vision, Clinical Research, Eye, Adolescent, Adult, Bardet-Biedl Syndrome, Chaperonins, Child, Child, Preschool, Electroretinography, Female, Humans, Male, Microtubule-Associated Proteins, Middle Aged, Mutation, Missense, Optical Imaging, Refraction, Ocular, Retina, Retinal Dystrophies, Retrospective Studies, Tomography, Optical Coherence, Visual Acuity, Visual Field Tests, Visual Fields, blindness, Bardet Biedl syndrome, retinal degeneration, genetics, natural history, end points, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4f15j5spTest

المؤلفون: LI Xiaying, WEI Yusheng, TIAN Yonglu, PANG Wanyong

المصدر: Shiyan dongwu yu bijiao yixue, Vol 42, Iss 6, Pp 566-571 (2022)

مصطلحات موضوعية: laboratory animals, scientific endpoints, humane intervention points, cumulative end points, Medicine

وصف الملف: electronic resource

العلاقة: https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.077Test; https://doaj.org/toc/1674-5817Test

الوصول الحر: https://doaj.org/article/d12234f0544e46afa40daa1d0bbec53cTest

المؤلفون: Nandaki Keshavan, Michelle Wood, Lucy M. Alderson, Mario Cortina‐Borja, Rachel Skeath, Mel McSweeney, Marjorie Dixon, Maureen A. Cleary, Emma Footitt, Spyros Batzios

المصدر: JIMD Reports, Vol 63, Iss 2, Pp 123-130 (2022)

مصطلحات موضوعية: arginase deficiency, hyperammonaemia, metabolic decompensation, trial end points, urea cycle disorder, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2192-8312Test

الوصول الحر: https://doaj.org/article/3a5fd91f81d1406a9b90d2ee80e7491aTest

المؤلفون: Layana-Castro, Pablo Emmanuel, García-Garví, Antonio, Navarro Moya, Francisco, Sánchez Salmerón, Antonio José

المساهمون: Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials, Archer Daniels Midland, AGENCIA ESTATAL DE INVESTIGACION, European Regional Development Fund, National Institutes of Health, EEUU

مصطلحات موضوعية: Synthetic dataset, Low-resolution image, U-net, Skeletonizing, End points, Caenorhabditis elegans, INGENIERIA DE SISTEMAS Y AUTOMATICA

العلاقة: International Journal of Computer Vision; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094312-B-I00/ES/MONITORIZACION AVANZADA DE COMPORTAMIENTOS DE CAENORHABDITIS ELEGANS, BASADA EN VISION ACTIVA, PARA ANALIZAR FUNCION COGNITIVA Y ENVEJECIMIENTO/; info:eu-repo/grantAgreement/AEI//PRE2019-088214//AYUDA PREDOCTORAL AEI-LAYANA CASTRO. PROYECTO: MONITORIZACION AVANZADA DE COMPORTAMIENTOS DE CAENORHABDITIS ELEGANS, BASADA EN VISION ACTIVA, PARA ANALIZAR FUNCION COGNITIVA Y ENVEJECIMIENTO/; info:eu-repo/grantAgreement/NIH//P40 OD010440/; https://doi.org/10.1007/s11263-023-01818-6Test; urn:issn:0920-5691; http://hdl.handle.net/10251/200935Test

الإتاحة: https://doi.org/10.1007/s11263-023-01818-6Test
http://hdl.handle.net/10251/200935Test

المؤلفون: Livius F. Muff, Sandor Balog, Jozef Adamcik, Christoph Weder, Roman Lehner

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Biotechnology, Ecology, Cancer, Space Science, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, biological end points, broadly applicable method, different np types, defined reference materials, different types, readily applicable, different systems, different fluorophores, tailorable characteristics, still missing, postfabrication process, possible impact, polymer nanoparticles, isolated reports, human health, heterogeneous geometries, complex environments, broad range, 100 nm, 1 macrophages

العلاقة: https://figshare.com/articles/journal_contribution/Preparation_of_Well-Defined_Fluorescent_Nanoplastic_Particles_by_Confined_Impinging_Jet_Mixing/24477137Test

الإتاحة: https://doi.org/10.1021/acs.est.3c03697.s002Test
https://figshare.com/articles/journal_contribution/Preparation_of_Well-Defined_Fluorescent_Nanoplastic_Particles_by_Confined_Impinging_Jet_Mixing/24477137Test