المؤلفون: William McCoull (1763365), Scott Boyd (1299897), Martin R. Brown (3368084), Muireann Coen (2022340), Olga Collingwood (10270208), Nichola L. Davies (2187538), Ann Doherty (11230947), Gary Fairley (1629775), Kristin Goldberg (1720258), Elizabeth Hardaker (6158861), Guang He (225824), Edward J. Hennessy (1533484), Philip Hopcroft (1613557), George Hodgson (11384115), Anne Jackson (8446269), Xiefeng Jiang (11384118), Ankur Karmokar (689971), Anne-Laure Lainé (11384121), Nicola Lindsay (3927482), Yumeng Mao (2296621), Roshini Markandu (11384124), Lindsay McMurray (2068162), Neville McLean (2128303), Lorraine Mooney (372137), Helen Musgrove (11384127), J. Willem M. Nissink (7424531), Alexander Pflug (2885099), Venkatesh Pilla Reddy (4270252), Philip B. Rawlins (3622793), Emma Rivers (9015803), Marianne Schimpl (208250), Graham F. Smith (2933100), Sharon Tentarelli (1765276), Jon Travers (818670), Robert I. Troup (11384130), Josephine Walton (8059682), Cheng Wang (102692), Stephen Wilkinson (176023), Beth Williamson (8306304), Jon Winter-Holt (8775911), Dejian Yang (11384133), Yuting Zheng (2176086), Qianxiu Zhu (11384136), Paul D. Smith (361345)

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, innate immune response, encoded library screen, >] pyridine series, preclinical mc38 immuno, based compound design, selective dual mer, 2 dual mer, axl kinase inhibitors, imidazo ­[ 1, probe compound, highly selective, current immuno, axl inhibitors, 2 ‑<, 2 -<, tumor microenvironment, target engagement, reduce lipophilicity, potential way

العلاقة: https://figshare.com/articles/journal_contribution/Optimization_of_an_Imidazo_1_2_i_a_i_pyridine_Series_to_Afford_Highly_Selective_Type_I1_2_Dual_Mer_Axl_Kinase_Inhibitors_with_i_In_Vivo_i_Efficacy/16569147Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00920.s001Test

المؤلفون: J. Willem M. Nissink (7424531), Sana Bazzaz (8932829), Carolyn Blackett (10270205), Matthew A. Clark (1370337), Olga Collingwood (10270208), Jeremy S. Disch (1960423), Diana Gikunju (8932826), Kristin Goldberg (1720258), John P. Guilinger (8932835), Elizabeth Hardaker (6158861), Edward J. Hennessy (1533484), Rachael Jetson (10270211), Anthony D. Keefe (3622769), William McCoull (1763365), Lindsay McMurray (2068162), Allison Olszewski (2671783), Ross Overman (1637866), Alexander Pflug (2885099), Marian Preston (3715579), Philip B. Rawlins (3622793), Emma Rivers (9015803), Marianne Schimpl (208250), Paul Smith (175833), Caroline Truman (112220), Elizabeth Underwood (9210380), Juli Warwicker (10270214), Jon Winter-Holt (8775911), Simon Woodcock (3682174), Ying Zhang (40767)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, lead-generation campaign, HT, selectivity profiles, data mining, kinase binding, cancer progression, orthogonal high-throughput screenin., DNA-encoded chemical library, campaign strategy, Concurrent execution, DECL screening, Mer inhibitors, screening outcomes, Comprehensive Lead-Generation Strat., kinase family, drug resistance, tumor microenvironment, TAM family members

العلاقة: https://figshare.com/articles/journal_contribution/Generating_Selective_Leads_for_Mer_Kinase_Inhibitors_Example_of_a_Comprehensive_Lead-Generation_Strategy/14179307Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c01904.s001Test

المؤلفون: William McCoull (1763365), Scott Boyd (1299897), Martin R. Brown (3368084), Muireann Coen (2022340), Olga Collingwood (10270208), Nichola L. Davies (2187538), Ann Doherty (11230947), Gary Fairley (1629775), Kristin Goldberg (1720258), Elizabeth Hardaker (6158861), Guang He (225824), Edward J. Hennessy (1533484), Philip Hopcroft (1613557), George Hodgson (11384115), Anne Jackson (8446269), Xiefeng Jiang (11384118), Ankur Karmokar (689971), Anne-Laure Lainé (11384121), Nicola Lindsay (3927482), Yumeng Mao (2296621), Roshini Markandu (11384124), Lindsay McMurray (2068162), Neville McLean (2128303), Lorraine Mooney (372137), Helen Musgrove (11384127), J. Willem M. Nissink (7424531), Alexander Pflug (2885099), Venkatesh Pilla Reddy (4270252), Philip B. Rawlins (3622793), Emma Rivers (9015803), Marianne Schimpl (208250), Graham F. Smith (2933100), Sharon Tentarelli (1765276), Jon Travers (818670), Robert I. Troup (11384130), Josephine Walton (8059682), Cheng Wang (102692), Stephen Wilkinson (176023), Beth Williamson (8306304), Jon Winter-Holt (8775911), Dejian Yang (11384133), Yuting Zheng (2176086), Qianxiu Zhu (11384136), Paul D. Smith (361345)

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, innate immune response, encoded library screen, >] pyridine series, preclinical mc38 immuno, based compound design, selective dual mer, 2 dual mer, axl kinase inhibitors, imidazo ­[ 1, probe compound, highly selective, current immuno, axl inhibitors, 2 ‑<, 2 -<, tumor microenvironment, target engagement, reduce lipophilicity, potential way

العلاقة: https://figshare.com/articles/dataset/Optimization_of_an_Imidazo_1_2_i_a_i_pyridine_Series_to_Afford_Highly_Selective_Type_I1_2_Dual_Mer_Axl_Kinase_Inhibitors_with_i_In_Vivo_i_Efficacy/16569150Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00920.s002Test

المؤلفون: J. Willem M. Nissink (7424531), Sana Bazzaz (8932829), Carolyn Blackett (10270205), Matthew A. Clark (1370337), Olga Collingwood (10270208), Jeremy S. Disch (1960423), Diana Gikunju (8932826), Kristin Goldberg (1720258), John P. Guilinger (8932835), Elizabeth Hardaker (6158861), Edward J. Hennessy (1533484), Rachael Jetson (10270211), Anthony D. Keefe (3622769), William McCoull (1763365), Lindsay McMurray (2068162), Allison Olszewski (2671783), Ross Overman (1637866), Alexander Pflug (2885099), Marian Preston (3715579), Philip B. Rawlins (3622793), Emma Rivers (9015803), Marianne Schimpl (208250), Paul Smith (175833), Caroline Truman (112220), Elizabeth Underwood (9210380), Juli Warwicker (10270214), Jon Winter-Holt (8775911), Simon Woodcock (3682174), Ying Zhang (40767)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, lead-generation campaign, HT, selectivity profiles, data mining, kinase binding, cancer progression, orthogonal high-throughput screenin., DNA-encoded chemical library, campaign strategy, Concurrent execution, DECL screening, Mer inhibitors, screening outcomes, Comprehensive Lead-Generation Strat., kinase family, drug resistance, tumor microenvironment, TAM family members

العلاقة: https://figshare.com/articles/dataset/Generating_Selective_Leads_for_Mer_Kinase_Inhibitors_Example_of_a_Comprehensive_Lead-Generation_Strategy/14179310Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c01904.s002Test