Minimum non-isotropic and asymmetric margins for taking into account intrafraction prostate motion during moderately hypofractionated radiotherapy
| العنوان: | Minimum non-isotropic and asymmetric margins for taking into account intrafraction prostate motion during moderately hypofractionated radiotherapy |
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| المؤلفون: | Francesca di Franco, Thomas Baudier, Frédéric Gassa, Alexandre Munoz, Murielle Martinon, Sarah Charcosset, Emilie Vigier-Lafosse, Pascal Pommier, David Sarrut, Marie-Claude Biston |
| المساهمون: | Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon], Imagerie Tomographique et Radiothérapie, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), di Franco, Francesca |
| المصدر: | Physica Medica Physica Medica, 2022, 96, pp.114-120. ⟨10.1016/j.ejmp.2022.03.006⟩ |
| بيانات النشر: | HAL CCSD, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Prostate cancer, Movement, Radiotherapy Planning, Computer-Assisted, Prostate, Biophysics, Prostatic Neoplasms, General Physics and Astronomy, [SDV.CAN]Life Sciences [q-bio]/Cancer, General Medicine, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Intrafraction motion, Margins, [SDV.CAN] Life Sciences [q-bio]/Cancer, Humans, Hypofractionation, Radiation Dose Hypofractionation, Radiology, Nuclear Medicine and imaging, Radiotherapy, Intensity-Modulated, Radiometry |
| الوصف: | International audience; Purpose: To investigate the impact on dose distribution of intrafraction motion during moderate hypofractionated prostate cancer treatments and to estimate minimum non-isotropic and asymmetric (NI-AS) treatment margins taking motion into account.Methods: Prostate intrafraction 3D displacements were recorded with a transperineal ultrasound probe and were evaluated in 46 prostate cancer patients (876 fractions) treated by moderate hypofractionated radiation therapy (60 Gy in 20 fractions). For 18 patients (346 fractions), treatment plans were recomputed increasing CTV-to-PTV margins from 0 to 6 mm with an auto-planning optimization algorithm. Dose distribution was estimated using the voxel shifting method by displacing CTV structure according to the retrieved movements. Time-dependentmargins were finally calculated using both van Herk’s formula and the voxel shifting method.Results: Mean intrafraction prostate displacements observed were - 0.02 ± 0.52 mm, 0.27 ± 0.78 mm and - 0.43 ± 1.06 mm in left–right, supero-inferior and antero-posterior directions, respectively. The CTV dosimetric coverage increased with increased CTV-to-PTV margins but it decreased with time. Hence using van Herk’s formula, after 7 min of treatment, a margin of 0.4 and 0.5 mm was needed in left and right, 1.5 and 0.7 mm in inferior and superior and 1.1 and 3.2 mm in anterior and posterior directions, respectively. Conversely, using the voxel shifting method, a margin of 0 mm was needed in left–right, 2 mm in superior, 3 mm in inferior and anterior and 5 mm in posterior directions, respectively. With this latter NI-AS margin strategy, the dosimetric target coverage was equivalent to the one obtained with a 5 mm homogeneous margin.Conclusions: NI-AS margins would be required to optimally take into account intrafraction motion. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1120-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594357b05487c6931670b54a12a28831Test https://hal.science/hal-03703011/documentTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....594357b05487c6931670b54a12a28831 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11201797 |
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