دورية أكاديمية
The role of hepcidin as a biomarker for iron status in patients with chronic kidney disease (stage IV and V) with negative virology
| العنوان: | The role of hepcidin as a biomarker for iron status in patients with chronic kidney disease (stage IV and V) with negative virology |
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| المؤلفون: | El Sharkawy, Magdy M, Elsaid, Heba W, Khedr, Lina E, Ibraheem, Ahmed M |
| المصدر: | QJM: An International Journal of Medicine ; volume 114, issue Supplement_1 ; ISSN 1460-2725 1460-2393 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | General Medicine |
| الوصف: | Background Anemia is a severe complication of chronic kidney disease (CKD) that is seen in more than 80% of patients with impaired renal function. Hepcidin, an acute phase reactant protein produced in the liver, is a key regulator of iron homeostasis. Aim of the Work to assess hepcidin level in 45 non-dialysis patients (CKD stage IV and V with negative virology) and its relation to iron parameters. Patients and Methods A cross sectional study was conducted at Nasser Institute for Treatment and Research on 45 patients with chronic kidney disease stage IV and V. All patients included in this study were subjected to the following: Careful history taking, full clinical examination and proper laboratory investigations. Results A statistically significant difference was found between CKD stage 4 and stage 5 according to Hb., iron, TIBC, Frerretin, serum and CRP. Also, there was a significant positive correlation of serum hepcidin with serum ferretin and hsCRP, while Hb and iron were significantly negatively correlated with hepcidin. We found statistically significant decrease in Hb level, serum Iron level, and TIBC in CKD stage 5 less than stage 4. We found statistically significant increase in Hepcidin level, serum ferritin, and hsCRP in CKD stage 5 more than stage 4. We found statistically significant Positive correlation between serum hepcidin with serum ferretin among patients with CKD stage 4 and 5. We found statistically significant Positive correlation between serum hepcidin with hsCRP among patients with CKD stage 4 and 5. We found statistically significant negative correlation between serum hepcidin with Hb among patients with CKD stage 4 and 5. A statistically significant Positive correlation between serum hepcidin with serum Iron among patients with CKD stage 4 and 5. Also we reported a statistically non-significant negative correlation between serum hepcidin and TIBC. Conclusion Elevated hepcidin can predict the need for parenteral iron to overcome hepcidin-mediated iron-restricted erythropoiesis ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/qjmed/hcab100.020 |
| الإتاحة: | https://doi.org/10.1093/qjmed/hcab100.020Test http://academic.oup.com/qjmed/article-pdf/114/Supplement_1/hcab100.020/40497238/hcab100.020.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.2CA1FAFB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/qjmed/hcab100.020 |
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