المؤلفون: Armin Hofmeister (1693609), Kerstin Jahn-Hofmann (3332715), Bodo Brunner (3332706), Mike W. Helms (9988071), Christiane Metz-Weidmann (8072303), Arne Krack (10752019), Michael Kurz (1578484), Ziyu Li (534234), Merle M. Weitzenberg (10752022), Elsa Pflimlin (1637635), Oliver Plettenburg (481045), Sabine Scheidler (9988080)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sense strand, morpholino GalNAc scaffolds, asialoglycoprotein-binding GalNAc l., morpholino GalNAc building blocks, siRNA sense strand, morpholine nitrogen, morpholino GalNAc moieties, Morpholine-Based Nucleotide Analogs, sense strand sequence, Hepatic siRNA Targeting, morpholine-based nucleotide analog

العلاقة: https://figshare.com/articles/journal_contribution/Syntheses_of_Morpholine-Based_Nucleotide_Analogs_for_Hepatic_siRNA_Targeting_and_Stabilization/14544319Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00144.s001Test

المؤلفون: Christiane Metz-Weidmann, Elsa Pflimlin, Kerstin Jahn-Hofmann, Ziyu Li, Bodo Brunner, Sabine Scheidler, Armin Hofmeister, Merle M Weitzenberg, Arne Krack, Mike W Helms, Oliver Plettenburg, Michael Kurz

المصدر: Journal of Medicinal Chemistry. 64:6838-6855

مصطلحات موضوعية: Small interfering RNA, Acetylgalactosamine, Morpholino, Stereochemistry, Morpholines, RNA Stability, Ligands, 01 natural sciences, Mice, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Morpholine, Drug Discovery, Animals, Prealbumin, Nucleotide, RNA, Small Interfering, Cells, Cultured, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Nucleotides, Chemistry, Ligand (biochemistry), 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Sense strand, Hepatocytes, Molecular Medicine, Female, RNA Interference, lipids (amino acids, peptides, and proteins), Linker

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da575d8ed74811c57899552ba2f2ae2cTest
https://doi.org/10.1021/acs.jmedchem.1c00144Test

المؤلفون: Matthew S. Tremblay, Huafei Zou, Shan Yu, Van Nguyen-Tran, Candy Lee, Elsa Pflimlin, Andrew To, Sam Lear, Sean B. Joseph, Weijun Shen

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Prolactin-releasing peptide, Organic Chemistry, Serum albumin, Fatty acid, Peptide, Pharmacology, Biochemistry, In vitro, Hypothalamus, In vivo, Drug Discovery, biology.protein, Potency

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91281208b5d2e2fb449e1c36acb9b09Test
https://doi.org/10.1021/acsmedchemlett.9b00182Test

المؤلفون: Claire Marsol, Christel Valencia, Thierry Durroux, Marcel Hibert, Dominique Bonnet, Julie Le Merrer, Pascal Villa, Marie-Céline Frantz, Jérôme A.J. Becker, Stéphanie Loison, Elsa Pflimlin, Bernard Mouillac, Lucie P. Pellissier, Jorge Gandía

المساهمون: Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Laboratoire d'Innovation Thérapeutique (LIT), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Bonnet, Dominique, International Mobility Programme to Strengthen Skills and Excellence in Research for Agriculture - AGREENSKILLS - - EC:FP7:PEOPLE2012-09-01 - 2017-02-28 - 267196 - VALID, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche du médicament Medalis - Drug Discovery Center [LabEx], Université de Strasbourg (UNISTRA), Plate-forme de chimie biologique intégrative de Strasbourg (PCBiS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS-Mission Interdisciplinaire, programme ITMM), Universite de Strasbourg, LabEx Medalis (Programme Investissement d'Avenir) [ANR-10-LABX-0034], French government [ANR-14-CE16-0005-01], Region Centre (ARD2020 Biomedicament-GPCRAb), LabEx MabImprove (Tours-Montpellier), Marie-Curie/AgreenSkills Program, European Project: 267196,EC:FP7:PEOPLE,FP7-PEOPLE-2010-COFUND,AGREENSKILLS(2012), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/ACS.JMEDCHEM.8B00697⟩
Journal of Medicinal Chemistry, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩

مصطلحات موضوعية: Male, 0301 basic medicine, Vasopressin, Pyrrolidines, Receptors, Opioid, mu, mu-opioid-receptor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Pharmacology, Ligands, in-vivo, Mice, 0302 clinical medicine, [CHIM] Chemical Sciences, Drug Discovery, human vasopressin, Receptor, ComputingMilieux_MISCELLANEOUS, Vasopressin receptor, Mice, Knockout, Chemistry, 3. Good health, Blood-Brain Barrier, Receptors, Oxytocin, randomized controlled-trial, Molecular Medicine, Female, μ-opioid receptor, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Agonist, medicine.drug_class, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, united-states, Structure-Activity Relationship, 03 medical and health sciences, mice lacking, medicine, Animals, Humans, [CHIM]Chemical Sciences, Interpersonal Relations, Autistic Disorder, Psychotropic Drugs, behavior, antagonist, medicine.disease, spectrum disorder, Oxytocin receptor, Disease Models, Animal, HEK293 Cells, 030104 developmental biology, Oxytocin, intranasal oxytocin, Pyrazoles, Autism, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726f80c9ac13303b955bab138bf1919cTest
https://doi.org/10.1021/acs.jmedchem.8b00697Test

المؤلفون: Zaid Amso, Avinash Muppiddi, Candy Lee, Qiangwei Fu, Vân T B Nguyen-Tran, Elsa Pflimlin, Sean B. Joseph, Zhihong Zhou, Weijun Shen

المصدر: Journal of medicinal chemistry. 63(1)

مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Serum albumin, Pharmacology, Oxytocin, Protein Engineering, 01 natural sciences, 03 medical and health sciences, Lipopeptides, Drug Discovery, Appetite Depressants, Weight Loss, medicine, Animals, Humans, Obesity, Receptor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Mice, Inbred BALB C, biology, Body Weight, Fatty acid, Oxytocin receptor, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Receptors, Oxytocin, biology.protein, Molecular Medicine, Carbetocin, Anti-Obesity Agents, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8592f2da43f8b53cab4c04a566d99b3aTest
https://pubmed.ncbi.nlm.nih.gov/31850759Test

المؤلفون: Elizabeth Chao, Ashley K. Woods, Elsa Pflimlin, Che-Hsiung Hsu, Avinash Muppidi, Madhupriya Mahankali, Andreas Crameri, Peng-Yu Yang, Huafei Zou, Danling Wang, Insha Ahmad, Sang Jun Lee, Weijun Shen, Candy Lee

المصدر: Bioconjugate chemistry. 30(1)

مصطلحات موضوعية: Acute decompensated heart failure, medicine.medical_treatment, Biomedical Engineering, Pharmaceutical Science, Bioengineering, 02 engineering and technology, Peptide hormone, Pharmacology, 01 natural sciences, In vivo, Fibrosis, Serelaxin, medicine, Animals, Humans, Amino Acid Sequence, Relaxin, Heart Failure, 010405 organic chemistry, Chemistry, Insulin, Organic Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, Lipids, Recombinant Proteins, 0104 chemical sciences, Heart failure, Drug Design, 0210 nano-technology, Biotechnology, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc7a94ad2d1dd62b8d82ef0f9f293e7Test
https://pubmed.ncbi.nlm.nih.gov/30543420Test

المؤلفون: Hiroshi Deguchi, Zihan Guo, Elsa Pflimlin, John H. Griffin, Weijun Shen, Mohammed Hayat

المصدر: Blood. 134:3622-3622

مصطلحات موضوعية: chemistry.chemical_classification, Immunology, Context (language use), Peptide, Cell Biology, Hematology, Phosphatidylserine, Biochemistry, Molecular biology, Amino acid, chemistry.chemical_compound, Thrombin, chemistry, Coagulation, Myosin, medicine, Binding site, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d33405b47c4806c4d01e685b883862ebTest
https://doi.org/10.1182/blood-2019-129161Test

المؤلفون: Elsa Pflimlin, Thierry Durroux, Iuliia A. Karpenko, Thiéric Rodriguez, Jean-François Margathe, Elodie Dupuis, Marcel Hibert, Dominique Bonnet

المصدر: Journal of Medicinal Chemistry. 58:2547-2552

مصطلحات موضوعية: Models, Molecular, High-throughput screening, Peptide, Ligands, Oxytocin, Drug Discovery, High-Throughput Screening Assays, Fluorescence Resonance Energy Transfer, Humans, Receptor, Fluorescent Dyes, chemistry.chemical_classification, Molecular Structure, Chemistry, Ligand binding assay, Combinatorial chemistry, Fluorescence, Oxytocin receptor, Kinetics, Förster resonance energy transfer, Receptors, Oxytocin, Drug Design, Biophysics, Molecular Medicine, Biological Assay, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816e50dbb2308aa241ce336db42b1028Test
https://doi.org/10.1021/jm501395bTest

المؤلفون: Elsa Pflimlin, Anish Konkar, Norbert Tennagels, Stefan Petry, Kristin Breitschopf, Paulus Wohlfart, Marcus Korn, Maximilian Bielohuby, Anja Pfenninger, Uwe Schwahn, Felix Bärenz, Matthias Löhn, Michael Podeschwa, Till Opatz, Marcel Reimann

المصدر: Cell Metabolism. 28:217-227.e13

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, geography, medicine.medical_specialty, geography.geographical_feature_category, Physiology, Glucose uptake, Fatty acid, 030209 endocrinology & metabolism, Endogeny, Cell Biology, Metabolism, Islet, medicine.disease, 03 medical and health sciences, Basal (phylogenetics), 030104 developmental biology, 0302 clinical medicine, Insulin resistance, Endocrinology, chemistry, Cell culture, Internal medicine, medicine, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3be84ea90beeaf543ee33fb2d6765289Test
https://doi.org/10.1016/j.cmet.2018.05.028Test

المؤلفون: Arasu Ganesan, Stéphanie Riché, Elsa Pflimlin, Marcel Hibert, Dominique Bonnet, Pete Doman, Sally Radford, Jean-François Margathe

المصدر: ACS Combinatorial Science. 14:323-334

مصطلحات موضوعية: Aza Compounds, 1h nmr spectroscopy, Peptidomimetic, Chemistry, Diketopiperazines, General Chemistry, General Medicine, Combinatorial chemistry, Solid-phase synthesis, Phase (matter), Combinatorial Chemistry Techniques, Organic chemistry, Solid-Phase Synthesis Techniques

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c595e6b871fd04b51122d731c9431fTest
https://doi.org/10.1021/co300015kTest