المؤلفون: Elomaa, Hanna, Härkönen, Jouni, Väyrynen, Sara A., Ahtiainen, Maarit, Ogino, Shuji, Nowak, Jonathan A., Lau, Mai Chan, Helminen, Olli, Wirta, Erkki Ville, Seppälä, Toni T., Böhm, Jan, Mecklin, Jukka Pekka, Kuopio, Teijo, Väyrynen, Juha P.

المساهمون: ATG - Applied Tumor Genomics, Faculty Common Matters (Faculty of Medicine), HUS Abdominal Center, Clinicum, II kirurgian klinikka

مصطلحات موضوعية: bioimage analysis, colorectal carcinoma, multiplex immunohistochemistry, prognostic factors, spatial analysis, tumor immunology, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: This study was funded by Cancer Foundation Finland (59-5619 to J.P.V. and to H.E.), Emil Aaltonen Foundation (220022K to H.E.), Orion Research Foundation sr (to H.E.), Päivikki and Sakari Sohlberg Foundation (to H.E.), Sigrid Jusélius Foundation (230229 to J.P.V.), and the State Research Funding (to J.P.V. and to H.E.). T.T.S. was supported by research grants from Jane and Aatos Erkko Foundation , Sigrid Jusélius Foundation , Finnish Medical Foundation, Emil Aaltonen Foundation , Cancer Foundation Finland , Relander Foundation , and the State Research Funding. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; Elomaa , H , Härkönen , J , Väyrynen , S A , Ahtiainen , M , Ogino , S , Nowak , J A , Lau , M C , Helminen , O , Wirta , E V , Seppälä , T T , Böhm , J , Mecklin , J P , Kuopio , T & Väyrynen , J P 2024 , ' Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer ' , Modern Pathology , vol. 37 , no. 4 , 100450 . https://doi.org/10.1016/j.modpat.2024.100450Test; http://hdl.handle.net/10138/575225Test; e69ac8a6-a901-434d-a712-34e6e6cfe5ea; 85187405899; 001203010700001

الإتاحة: http://hdl.handle.net/10138/575225Test

المؤلفون: Karjula, Topias, Elomaa, Hanna, Vayrynen, Sara A., Kuopio, Teijo, Ahtiainen, Maarit, Mustonen, Olli, Puro, Iiris, Niskakangas, Anne, Mecklin, Jukka-Pekka, Bohm, Jan, Wirta, Erkki-Ville, Seppälä, Toni T., Sihvo, Eero, Yannopoulos, Fredrik, Helminen, Olli, Väyrynen, Juha P.

المساهمون: ATG - Applied Tumor Genomics, Faculty Common Matters (Faculty of Medicine), HUS Abdominal Center, II kirurgian klinikka, HUS Heart and Lung Center

مصطلحات موضوعية: Cancer immunology, Colorectal cancer, Macrophage polarisation, Pulmonary metastases, Tumour-associated macrophages, 3122 Cancers

وصف الملف: application/pdf

العلاقة: The study benefited from samples/data from Northern Finland Biobank Borealis (Oulu, Finland) (https://oys.fi/biopankkiTest/).; Karjula , T , Elomaa , H , Vayrynen , S A , Kuopio , T , Ahtiainen , M , Mustonen , O , Puro , I , Niskakangas , A , Mecklin , J-P , Bohm , J , Wirta , E-V , Seppälä , T T , Sihvo , E , Yannopoulos , F , Helminen , O & Väyrynen , J P 2024 , ' Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancer ' , Cancer Immunology, Immunotherapy , vol. 73 , no. 3 , 59 . https://doi.org/10.1007/s00262-024-03646-0Test; ORCID: /0000-0002-4940-3498/work/156151967; http://hdl.handle.net/10138/573397Test; b355bc98-d564-4c9a-97c8-f607a2862d3f; 001169640500001

الإتاحة: http://hdl.handle.net/10138/573397Test

المؤلفون: Karjula, Topias, Elomaa, Hanna, Niskakangas, Anne, Mustonen, Olli, Puro, Iiris, Kuopio, Teijo, Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Seppälä, Toni T., Wirta, Erkki-Ville, Sihvo, Eero, Väyrynen, Juha P., Yannopoulos, Fredrik, Helminen, Olli

المساهمون: ATG - Applied Tumor Genomics, HUS Abdominal Center, II kirurgian klinikka, HUS Heart and Lung Center

مصطلحات موضوعية: Colorectal carcinoma, Programmed death 1, Programmed death ligand 1, Pulmonary metastases, Tumour-infiltrating lymphocytes, 3122 Cancers

وصف الملف: application/pdf

العلاقة: This study was funded by Instrumentarium Science Foundation (O.H.), Mary and Georg C. Ehrnrooth Foundation (O.H.), Finnish State Research Funding (O.H.), and Cancer Foundation Finland (J.P.V.), J&A Erkko Foundation (J.-P.M.).; Karjula , T , Elomaa , H , Niskakangas , A , Mustonen , O , Puro , I , Kuopio , T , Ahtiainen , M , Mecklin , J-P , Seppälä , T T , Wirta , E-V , Sihvo , E , Väyrynen , J P , Yannopoulos , F & Helminen , O 2023 , ' CD3(+) and CD8(+) T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer ' , Cancers , vol. 15 , no. 1 . https://doi.org/10.3390/cancers15010206Test; ORCID: /0000-0002-4940-3498/work/128513942; 4db5ffe1-c977-4855-93f5-96df6ce454b4; http://hdl.handle.net/10138/572914Test; 000910425000001

الإتاحة: http://hdl.handle.net/10138/572914Test

المؤلفون: Karjula, Topias, Kemi, Niko, Niskakangas, Anne, Mustonen, Olli, Puro, Iiris, Pohjanen, Vesa-Matti, Kuopio, Teijo, Elomaa, Hanna, Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Seppälä, Toni T., Wirta, Erkki-Ville, Sihvo, Eero, Väyrynen, Juha P., Yannopoulos, Fredrik, Helminen, Olli

المساهمون: ATG - Applied Tumor Genomics, HUS Abdominal Center, Research Programs Unit, II kirurgian klinikka, HUS Heart and Lung Center

مصطلحات موضوعية: Colorectal cancer, Pulmonary metastases, Tumor budding, Tumor-stroma ratio, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

العلاقة: Karjula , T , Kemi , N , Niskakangas , A , Mustonen , O , Puro , I , Pohjanen , V-M , Kuopio , T , Elomaa , H , Ahtiainen , M , Mecklin , J-P , Seppälä , T T , Wirta , E-V , Sihvo , E , Väyrynen , J P , Yannopoulos , F & Helminen , O 2023 , ' The prognostic role of tumor budding and tumor-stroma ratio in pulmonary metastasis of colorectal carcinoma ' , European Journal of Surgical Oncology , vol. 49 , no. 7 , pp. 1298-1306 . https://doi.org/10.1016/j.ejso.2023.02.009Test; ORCID: /0000-0002-4940-3498/work/140317438; fd2757af-887f-4900-af90-6570a2d0e853; http://hdl.handle.net/10138/572608Test; 001022268500001

الإتاحة: http://hdl.handle.net/10138/572608Test

المؤلفون: Karjula, Topias, Kemi, Niko, Niskakangas, Anne, Mustonen, Olli, Puro, Iiris, Pohjanen, Vesa Matti, Kuopio, Teijo, Elomaa, Hanna, Ahtiainen, Maarit, Mecklin, Jukka Pekka, Seppälä, Toni T., Wirta, Erkki Ville, Sihvo, Eero, Väyrynen, Juha P., Yannopoulos, Fredrik, Helminen, Olli

المساهمون: Tampere University, Clinical Medicine, TAYS Cancer Centre, GAST, Gastroenterology

مصطلحات موضوعية: 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology

وصف الملف: fulltext

العلاقة: 49; ORCID: /0000-0002-4940-3498/work/137649392; ORCID: /0000-0002-2255-6136/work/137649597; https://trepo.tuni.fi/handle/10024/150126Test; URN:NBN:fi:tuni-202306276926

الإتاحة: https://doi.org/10.1016/j.ejso.2023.02.009Test
https://trepo.tuni.fi/handle/10024/150126Test

المؤلفون: Kastinen, Meeri, Sirniö, Päivi, Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Herzig, Karl-Heinz, Meriläinen, Sanna, Aro, Raila, Häivälä, Reetta, Rautio, Tero, Saarnio, Juha, Wirta, Erkki-Ville, Helminen, Olli, Seppälä, Toni T., Kuopio, Teijo, Böhm, Jan, Tuomisto, Anne, Mecklin, Jukka-Pekka, Mäkinen, Markus J., Väyrynen, Juha P.

المساهمون: Tampere University, Clinical Medicine, TAYS Cancer Centre, GAST, Gastroenterology

مصطلحات موضوعية: 1182 Biochemistry, cell and molecular biology, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology

وصف الملف: fulltext

العلاقة: 12; 128; ORCID: /0000-0002-4940-3498/work/133055343; ORCID: /0000-0002-2255-6136/work/133430894; https://trepo.tuni.fi/handle/10024/147393Test; URN:NBN:fi:tuni-202304193902

الإتاحة: https://doi.org/10.1038/s41416-023-02258-2Test
https://trepo.tuni.fi/handle/10024/147393Test

المؤلفون: Karjula, Topias, Niskakangas, Anne, Mustonen, Olli, Puro, Iiris, Elomaa, Hanna, Ahtiainen, Maarit, Kuopio, Teijo, Mecklin, Jukka Pekka, Seppälä, Toni T., Wirta, Erkki Ville, Sihvo, Eero, Yannopoulos, Fredrik, Helminen, Olli, Väyrynen, Juha P.

المساهمون: Tampere University, Clinical Medicine, TAYS Cancer Centre, Department of Gastroenterology

مصطلحات موضوعية: 3121 Internal medicine, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology

وصف الملف: fulltext

العلاقة: 483; ORCID: /0000-0002-4940-3498/work/140915514; ORCID: /0000-0002-2255-6136/work/140915911; https://trepo.tuni.fi/handle/10024/150650Test; URN:NBN:fi:tuni-202308217685

الإتاحة: https://doi.org/10.1007/s00428-023-03577-8Test
https://trepo.tuni.fi/handle/10024/150650Test

المؤلفون: Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Ogino, Shuji, Nowak, Jonathan A., Lau, Mai Chan, Helminen, Olli, Wirta, Erkki-Ville, Seppälä, Toni T., Böhm, Jan, Mecklin, Jukka-Pekka, Kuopio, Teijo, Väyrynen, Juha P.

المساهمون: ATG - Applied Tumor Genomics, HUS Abdominal Center, II kirurgian klinikka

مصطلحات موضوعية: Tumor-associated macrophages, Microenvironment, Contexture, Prognosis, Density, 3122 Cancers

وصف الملف: application/pdf

العلاقة: Elomaa , H , Ahtiainen , M , Väyrynen , S A , Ogino , S , Nowak , J A , Lau , M C , Helminen , O , Wirta , E-V , Seppälä , T T , Böhm , J , Mecklin , J-P , Kuopio , T & Väyrynen , J P 2023 , ' Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer ' , British Journal of Cancer , vol. 128 , no. 11 , pp. 2104–2115 . https://doi.org/10.1038/s41416-023-02238-6Test; ORCID: /0000-0002-4940-3498/work/140317440; 49c7edf8-8d63-462b-b5ba-ab57b6b19f20; http://hdl.handle.net/10138/563822Test; 000961182700001

الإتاحة: http://hdl.handle.net/10138/563822Test

المؤلفون: Karjula, Topias, Elomaa, Hanna, Niskakangas, Anne, Mustonen, Olli, Puro, Iiris, Kuopio, Teijo, Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Seppälä, Toni, T., Wirta, Erkki-Ville, Sihvo, Eero, Väyrynen, Juha, P., Yannopoulos, Fredrik, Helminen, Olli

مصطلحات موضوعية: colorectal carcinoma, pulmonary metastases, tumour-infiltrating lymphocytes, programmed death 1, programmed death ligand 1, etäpesäkkeet, karsinoomat, keuhkot, paksusuolisyöpä, syöpätaudit

وصف الملف: application/pdf; fulltext

العلاقة: Cancers; 15; Karjula, T., Elomaa, H., Niskakangas, A., Mustonen, O., Puro, I., Kuopio, T., Ahtiainen, M., Mecklin, J.-P., Seppälä, T., Wirta, E.-V., Sihvo, E., Väyrynen, J., Yannopoulos, F., & Helminen, O. (2023). CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer. Cancers , 15 (1), Article 206. https://doi.org/10.3390/cancers15010206Test; CONVID_176467955; URN:NBN:fi:jyu-202301311548; http://urn.fi/URN:NBN:fi:jyu-202301311548Test

الإتاحة: http://urn.fi/URN:NBN:fi:jyu-202301311548Test

المؤلفون: Härkönen, Jouni, Pölönen, Petri, Jawahar Deen, Ashik, Selvarajan, Ilakya, Teppo, Hanna-Riikka, Dimova, Elitsa Y., Kietzmann, Thomas, Ahtiainen, Maarit, Väyrynen, Juha P., Väyrynen, Sara A., Elomaa, Hanna, Tynkkynen, Niko, Eklund, Tiia, Kuopio, Teijo, Talvitie, Eva-Maria, Taimen, Pekka, Kallajoki, Markku, Kaikkonen, Minna, U., Heinäniemi, Merja, Levonen, Anna-Liisa

مصطلحات موضوعية: NRF2, KEAP1, Redox, Squamous, T cells, Interferon gamma, HLA-I, SOX2, TP63, PD-L1, T-imusolut, interferonit, soluviestintä, syöpäsolut, transkriptiotekijät, immuunivaste

وصف الملف: application/pdf; fulltext

العلاقة: Redox Biology; 61; Härkönen, J., Pölönen, P., Jawahar Deen, A., Selvarajan, I., Teppo, H.-R., Dimova, E. Y., Kietzmann, T., Ahtiainen, M., Väyrynen, J. P., Väyrynen, S. A., Elomaa, H., Tynkkynen, N., Eklund, T., Kuopio, T., Talvitie, E.-M., Taimen, P., Kallajoki, M., Kaikkonen, M., Heinäniemi, M., & Levonen, A.-L. (2023). A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies. Redox Biology , 61 , Article 102644. https://doi.org/10.1016/j.redox.2023.102644Test; CONVID_177158565; URN:NBN:fi:jyu-202303132132; http://urn.fi/URN:NBN:fi:jyu-202303132132Test

الإتاحة: http://urn.fi/URN:NBN:fi:jyu-202303132132Test