المؤلفون: Sarah Cooper, Anne Grijzenhout, Elizabeth Underwood, Katia Ancelin, Tianyi Zhang, Tatyana B. Nesterova, Burcu Anil-Kirmizitas, Andrew Bassett, Susanne M. Kooistra, Karl Agger, Kristian Helin, Edith Heard, Neil Brockdorff

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/b92aed92ccad489c830eec2852858b92Test

المؤلفون: Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7ab848514085441b822b8a2f77f90739Test

المؤلفون: Jeffrey W. Johannes (1414039), Amber Balazs (9436515), Derek Barratt (8921054), Michal Bista (160356), Matthew D. Chuba (11486389), Sabina Cosulich (466728), Susan E. Critchlow (1613527), Sébastien L. Degorce (1436623), Paolo Di Fruscia (3748813), Scott D. Edmondson (1416967), Kevin Embrey (1637887), Stephen Fawell (5867138), Avipsa Ghosh (1329021), Sonja J. Gill (11486392), Anders Gunnarsson (1454497), Sudhir M. Hande (2047519), Tom D. Heightman (236769), Paul Hemsley (4414534), Giuditta Illuzzi (11486395), Jordan Lane (11486398), Carrie Larner (11486401), Elisabetta Leo (16336), Lina Liu (227490), Andrew Madin (2369338), Scott Martin (8770), Lisa McWilliams (3115182), Mark J. O’Connor (512930), Jonathan P. Orme (2570623), Fiona Pachl (1643695), Martin J. Packer (1716334), Xiaohui Pei (8775905), Andrew Pike (689657), Marianne Schimpl (208250), Hongyao She (11486404), Anna D. Staniszewska (11486407), Verity Talbot (6084164), Elizabeth Underwood (9210380), Jeffrey G. Varnes (2499496), Lin Xue (826042), Tieguang Yao (9761206), Ke Zhang (115386), Andrew X. Zhang (1371321), Xiaolan Zheng (1638844)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overlapping hematological toxicities, good secondary pharmacology, brca mutant hbcx, brca mutant background, achieved regulatory approval, 17 pdx model, parp family members, oxo ‑ 5, dihydro ‑ 1, selective parp1 inhibitor, 25 , n <, highly selective, vivo efficacy, usually due, reduced effects, recent literature, preclinical species, physicochemical properties, parps poly, parp1 inhibition, line chemotherapies

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_5_4-_7-Ethyl-6-oxo_5_6-dihydro_1_5-naphthyridin-3-yl_methyl_piperazin-1-yl_i_N_i_methyl_pyridine-2-carboxamide_AZD5305_A_PARP1_DNA_Trapper_with_High_Selectivity_for_PARP1_over_PARP2_and_Other_PARPs/16688962Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01012.s001Test

المؤلفون: Claudia De Fusco (10701793), Marianne Schimpl (208250), Ulf Börjesson (2385130), Tony Cheung (62045), Iain Collie (5742095), Laura Evans (4070059), Priyanka Narasimhan (10701796), Christopher Stubbs (3601565), Mercedes Vazquez-Chantada (8306307), David J. Wagner (10701799), Michael Grondine (1981477), Matthew G. Sanders (10701802), Sharon Tentarelli (1765276), Elizabeth Underwood (9210380), Argyrides Argyrou (1493980), James M. Smith (1613530), James T. Lynch (10701805), Elisabetta Chiarparin (1871695), Graeme Robb (3901684), Sharan K. Bagal (1586119), James S. Scott (1398391)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, MTAP-deleted cancers, antitumor response, Potent MAT 2a Inhibitor, MTAP knockout HCT 116 xenograft model, allosteric site, generation campaign, ATP, hits binding, SAM-dependent methylation events, MAT 2a inhibitors, MTAP-null cells, vivo tool compound 28, vivo studies, Vivo Evaluation, p 16, Fragment-Based Design, MTAP genes, metabolite S, structure-guided design, MTAP Null Xenograft Model MAT 2a, arylquinazolinone series, methionine adenosyltransferase

العلاقة: https://figshare.com/articles/journal_contribution/Fragment-Based_Design_of_a_Potent_MAT2a_Inhibitor_and_i_in_Vivo_i_Evaluation_in_an_MTAP_Null_Xenograft_Model/14486701Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00067.s001Test

المؤلفون: J. Willem M. Nissink (7424531), Sana Bazzaz (8932829), Carolyn Blackett (10270205), Matthew A. Clark (1370337), Olga Collingwood (10270208), Jeremy S. Disch (1960423), Diana Gikunju (8932826), Kristin Goldberg (1720258), John P. Guilinger (8932835), Elizabeth Hardaker (6158861), Edward J. Hennessy (1533484), Rachael Jetson (10270211), Anthony D. Keefe (3622769), William McCoull (1763365), Lindsay McMurray (2068162), Allison Olszewski (2671783), Ross Overman (1637866), Alexander Pflug (2885099), Marian Preston (3715579), Philip B. Rawlins (3622793), Emma Rivers (9015803), Marianne Schimpl (208250), Paul Smith (175833), Caroline Truman (112220), Elizabeth Underwood (9210380), Juli Warwicker (10270214), Jon Winter-Holt (8775911), Simon Woodcock (3682174), Ying Zhang (40767)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, lead-generation campaign, HT, selectivity profiles, data mining, kinase binding, cancer progression, orthogonal high-throughput screenin., DNA-encoded chemical library, campaign strategy, Concurrent execution, DECL screening, Mer inhibitors, screening outcomes, Comprehensive Lead-Generation Strat., kinase family, drug resistance, tumor microenvironment, TAM family members

العلاقة: https://figshare.com/articles/journal_contribution/Generating_Selective_Leads_for_Mer_Kinase_Inhibitors_Example_of_a_Comprehensive_Lead-Generation_Strategy/14179307Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c01904.s001Test

المؤلفون: Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista

المصدر: Journal of Medicinal Chemistry. 64:14498-14512

مصطلحات موضوعية: chemistry.chemical_compound, PARP1, Chemistry, In vivo, Poly ADP ribose polymerase, Drug Discovery, Mutant, Cancer research, Molecular Medicine, Progenitor cell, Homologous recombination, DNA, In vitro

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5da59f02fe0bf1798c2492422c31c3Test
https://doi.org/10.1021/acs.jmedchem.1c01012Test

المؤلفون: Marie-France Langelier, Michael McCauley, Elizabeth Underwood, Laura E. Easton, Ji-Chun Yang, David Neuhaus, Kevin J. Embrey, Philip B. Rawlins, John M. Pascal, Marianne Schimpl, Tom E. H. Ogden

المصدر: Nucleic Acids Research

مصطلحات موضوعية: Models, Molecular, AcademicSubjects/SCI00010, DNA repair, DNA damage, Poly ADP ribose polymerase, Allosteric regulation, Mutant, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Allosteric Regulation, Protein Domains, Structural Biology, Catalytic Domain, Genetics, 030304 developmental biology, 0303 health sciences, Substrate Interaction, biology, Active site, Amides, 0104 chemical sciences, 3. Good health, Enzyme Activation, chemistry, 030220 oncology & carcinogenesis, Mutation, Biophysics, biology.protein, DNA, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797bf973be4d902f491aa1173a7f7e07Test
https://doi.org/10.1093/nar/gkab020Test

المؤلفون: Alice R Eddershaw, Karl Syson, Paul R. J. Davey, Gregory Hamm, Christopher D. Stubbs, Paul Clarkson, Elizabeth Underwood, Lucy V Edwardes

المصدر: Biochemistry. 59:4775-4786

مصطلحات موضوعية: Models, Molecular, Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, In Vitro Techniques, Biochemistry, Mass Spectrometry, Substrate Specificity, 03 medical and health sciences, Protein structure, Catalytic Domain, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Enzyme Inhibitors, Protein Structure, Quaternary, Ternary complex, Adaptor Proteins, Signal Transducing, 0303 health sciences, Chemistry, Protein arginine methyltransferase 5, 030302 biochemistry & molecular biology, Deuterium Exchange Measurement, Recombinant Proteins, Kinetics, Biophysics, Hydrogen–deuterium exchange, Steady state (chemistry)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c63875119c271f482688a035fe6bfcTest
https://doi.org/10.1021/acs.biochem.0c00554Test

المؤلفون: William McCoull, Jon Winter-Holt, Marianne Schimpl, Elizabeth Underwood, Ross Overman, Juli Warwicker, Philip B. Rawlins, J. Willem M. Nissink, Alexander Pflug, Caroline Truman

المصدر: Biochemical Journal

مصطلحات موضوعية: Biophysics, Context (language use), Biochemistry, Protein Structure, Secondary, 03 medical and health sciences, Adenosine Triphosphate, MerTK, 0302 clinical medicine, Structural Biology, Humans, Kinome, Protein Kinase Inhibitors, Molecular Biology, Research Articles, Cancer, 030304 developmental biology, 0303 health sciences, c-Mer Tyrosine Kinase, Chemistry, Kinase, Pharmacology & Toxicology, Cell Biology, activation loop, MERTK, Receptor–ligand kinetics, activation segment, TAM, Protein kinase domain, 030220 oncology & carcinogenesis, Phosphorylation, Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d4c6e582a9e63dc834895d8a9b2deaTest
https://doi.org/10.1042/bcj20200735Test

المؤلفون: Patterson, Elizabeth Underwood

المصدر: Language Arts. Jul 2002 79(6):515-520.

تمت مراجعته من قبل الزملاء: Y

Page Count: 6

الواصفات: Childrens Literature, Elementary Education, Interviews, Professional Development

رمز الدورية: CIJDEC2002