Iloprost Inhalation in Mild Asthma
| العنوان: | Iloprost Inhalation in Mild Asthma |
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| المؤلفون: | Aimee Hoskins, Elizabeth Majeski, Ryszard Dworski, James R. Sheller |
| المصدر: | Journal of Asthma. 49:961-965 |
| بيانات النشر: | Informa UK Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Pulmonary and Respiratory Medicine, Spirometry, Blood Pressure, Prostacyclin, Nitric Oxide, Administration, Inhalation, medicine, Humans, Immunology and Allergy, Prostaglandins I, Iloprost, Asthma, Dose-Response Relationship, Drug, Inhalation, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Blood pressure, Anesthesia, Pediatrics, Perinatology and Child Health, Exhaled nitric oxide, cardiovascular system, Female, lipids (amino acids, peptides, and proteins), Methacholine, Bronchial Hyperreactivity, business, medicine.drug |
| الوصف: | Objective. To determine the feasibility of administering iloprost by inhalation in patients with mild atopic asthma. Methods. Volunteers underwent supervised inhalation of iloprost in the clinic with measurement of spirometry and blood pressure for 2 hours. The volunteers then inhaled iloprost four times daily at a dose of 2.5 or 5 μg for 14 days. Spirometry, asthma questionnaires, peak flow diaries, measurement of methacholine responsiveness, and exhaled nitric oxide concentrations were obtained prior to and after the treatment period. Results. Chronic inhalation of iloprost (2.5–5 μg) did not alter spirometry or methacholine responsiveness. Conclusion. Inhaled iloprost in carefully selected volunteers with mild asthma appears to be a suitable intervention to explore the effects of prostacyclin in human asthma. |
| تدمد: | 1532-4303 0277-0903 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3be2c0da4316450235dec60a089451Test https://doi.org/10.3109/02770903.2012.724130Test |
| رقم الانضمام: | edsair.doi.dedup.....7b3be2c0da4316450235dec60a089451 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324303 02770903 |
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