Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes
| العنوان: | Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes |
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| المؤلفون: | Tor Ivar Hansen, Trond Sand, Elise Cd Haferstrom, Marit R. Bjørgaas, Sandra Elise Olsen, Brian M. Frier, Asta Håberg |
| المصدر: | Diabetologia |
| بيانات النشر: | Springer Berlin Heidelberg, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Pattern separation, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Article, Impaired awareness of hypoglycaemia, 03 medical and health sciences, 0302 clinical medicine, Cognition, Memory, Surveys and Questionnaires, Internal Medicine, Medicine, Humans, Insulin, Prospective Studies, Association (psychology), Type 1 diabetes, business.industry, nutritional and metabolic diseases, Human physiology, Middle Aged, medicine.disease, Hypoglycemia, Cognitive test, Diabetes Mellitus, Type 1, Female, Cognitive function, business, Hypoglycaemia, Cognition Disorders, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Aims/hypothesis The aim of this study was to compare cognitive function in adults with type 1 diabetes who have impaired awareness of hypoglycaemia with those who have normal awareness of hypoglycaemia. A putative association was sought between cognitive test scores and a history of severe hypoglycaemia. Methods A total of 68 adults with type 1 diabetes were included: 33 had impaired and 35 had normal awareness of hypoglycaemia, as confirmed by formal testing. The groups were matched for age, sex and diabetes duration. Cognitive tests of verbal memory, object-location memory, pattern separation, executive function, working memory and processing speed were administered. Results Participants with impaired awareness of hypoglycaemia scored significantly lower on the verbal and object-location memory tests and on the pattern separation test (Cohen’s d −0.86 to −0.55 [95% CI −1.39, −0.05]). Participants with impaired awareness of hypoglycaemia had reduced planning ability task scores, although the difference was not statistically significant (Cohen’s d 0.57 [95% CI 0, 1.14]). Frequency of exposure to severe hypoglycaemia correlated with the number of cognitive tests that had not been performed according to instructions. Conclusions/interpretation Impaired awareness of hypoglycaemia was associated with diminished learning, memory and pattern separation. These cognitive tasks all depend on the hippocampus, which is vulnerable to neuroglycopenia. The findings suggest that hypoglycaemia contributes to the observed correlation between impaired awareness of hypoglycaemia and impaired cognition. © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| اللغة: | English |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39bdda7b8abbbf249463ca8282b4834Test http://europepmc.org/articles/PMC5423963Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d39bdda7b8abbbf249463ca8282b4834 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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