المؤلفون: Kudtarkar, Parul, Melton, Rebecca, Mummey, Hannah, Benaglio, Paola, Okino, Mei-Lin, Gaulton, Kyle, Elgamal, Ruth

المصدر: Diabetes. 72(11)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3fr0n83vTest
https://escholarship.org/content/qt3fr0n83v/qt3fr0n83v.pdfTest

المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei-Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret KR, Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A, Sander, Maike, Gaulton, Kyle J

المصدر: Cell Genomics. 2(12)

مصطلحات موضوعية: Biochemistry and Cell Biology, Genetics, Biological Sciences, Diabetes, Autoimmune Disease, Prevention, Human Genome, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, 3D chromatin interactions, CRISPR screen, accessible chromatin, beta cell, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8wv9b80nTest

المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret K.R., Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A., Sander, Maike, Gaulton, Kyle J.

المساهمون: Department of Pathology, Biosciences, Doctoral Programme in Integrative Life Science, Jussi Taipale / Principal Investigator

مصطلحات موضوعية: 3D chromatin interactions, accessible chromatin, beta cell, CRISPR screen, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes, General medicine, internal medicine and other clinical medicine, Biomedicine

وصف الملف: application/pdf

العلاقة: The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S., K.F., K.J.G., and B.R.; and DK105541 to M.S., K.F., and B.R. The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S. K.F. K.J.G. and B.R.; and DK105541 to M.S. K.F. and B.R. K.J.G. and M.S. conceived of and supervised the study. K.J.G. P.B. H.Z. M.O. and M.S. wrote the manuscript. J.T. and B.R. supervised the design and generation of SNP-SELEX data. K.F. supervised the design of SNP-SELEX and analyses of genomic data. S.P. supervised generation of single-cell data. P.B. performed statistical data analysis of genomic, CRISPR-KO screen, and genetic data; H.Z. performed the CRISPR-KO screen and interpreted the results; M.O. and M.M. performed genomic assays. J.Y. performed the SNP-SELEX assay. P.B. M.O. R.E. E.B. K.K. A.A. J.C. G.W. and J.N. performed bulk and single-cell data analysis. M.O. R.E. J.K. and S.C. performed functional validation experiments. P.B. N.N. Y.Q. A.A. and M.K.D. performed design and analysis of SNP-SELEX data. All authors contributed to and approved of the final version of the manuscript. K.J.G. is a consultant of Genentech and holds stock in Neurocrine Biosciences. B.R. is a consultant of Arima Genomics and a co-founder of Epigenome Technologies. P.B. is an employee of Shoreline Bioscience. N.N. is an employee of Guardant Health. E.B. is an employee and shareholder of Aetion. K.K. is an employee of Cartography Bio. Y.Q. is an employee of Sana Biotechnology. M.D. is an employee and shareholder of Seer. J.C. is an employee and shareholder of Pfizer.; Benaglio , P , Zhu , H , Okino , M L , Yan , J , Elgamal , R , Nariai , N , Beebe , E , Korgaonkar , K , Qiu , Y , Donovan , M K R , Chiou , J , Wang , G , Newsome , J , Kaur , J , Miller , M , Preissl , S , Corban , S , Aylward , A , Taipale , J , Ren , B , Frazer , K A , Sander , M & Gaulton , K J 2022 , ' Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines ' , Cell genomics , vol. 2 , no. 12 , 100214 . https://doi.org/10.1016/j.xgen.2022.100214Test; http://hdl.handle.net/10138/354977Test; c6a62712-0c8b-4078-9442-a6813e9052b5; 85143868567

الإتاحة: http://hdl.handle.net/10138/354977Test

المؤلفون: Qadir, Mirza Muhammad Fahd, Elgamal, Ruth M, Song, Keijing, Kudtarkar, Parul, Sakamuri, Siva S V P, Katakam, Prasad V, El-Dahr, Samir, Kolls, Jay, Gaulton, Kyle J, Mauvais-Jarvis, Franck

المصدر: bioRxiv

مصطلحات موضوعية: Diabetes, Islet, Multiomics, Sex Differences, Systems Biology, scRNAseq, snATACseq, β cell

العلاقة: https://doi.org/10.1101/2024.04.11.589096Test; https://pubmed.ncbi.nlm.nih.gov/38645001Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11030320Test/

الإتاحة: https://doi.org/10.1101/2024.04.11.589096Test
https://pubmed.ncbi.nlm.nih.gov/38645001Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11030320Test/

المؤلفون: Elgamal, Ruth M.¹, Kudtarkar, Parul², Melton, Rebecca L.¹, Mummey, Hannah M.³, Benaglio, Paola², Okino, Mei-Lin¹, Gaulton, Kyle J.² kgaulton@health.ucsd.edu

المصدر: Diabetes. Nov2023, Vol. 72 Issue 11, p1719-1728. 10p.

مصطلحات موضوعية: *ISLANDS of Langerhans, *GENE expression, *TYPE 1 diabetes, *TYPE 2 diabetes, *RNA sequencing

المؤلفون: Lee, Miseon, Maji, Basudeb, Manna, Debasish, Kahraman, Sevim, Elgamal, Ruth M., Small, Jonnell, Kokkonda, Praveen, Vetere, Amedeo, Goldberg, Jacob M., Lippard, Stephen J., Kulkarni, Rohit N., Wagner, Bridget K., Choudhary, Amit

المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases, Burroughs Wellcome Fund, Integrated Islet Distribution Program

المصدر: Journal of the American Chemical Society ; volume 142, issue 14, page 6477-6482 ; ISSN 0002-7863 1520-5126

الإتاحة: https://doi.org/10.1021/jacs.0c00099Test

المؤلفون: Elgamal, Ruth M, Kudtarkar, Parul, Melton, Rebecca L, Mummey, Hannah M, Benaglio, Paola, Okino, Mei-Lin, Gaulton, Kyle J

المصدر: bioRxiv

مصطلحات موضوعية: Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf56bbcf632e7c7b4ded701330e6f31Test
https://doi.org/10.1101/2023.02.03.526994Test

المؤلفون: Kuljanin, Miljan, Elgamal, Ruth M., Bell, Gillian I., Xenocostas, Anargyros, Lajoie, Gilles A., Hess, David A.

المساهمون: Sheldon H. Weinstein Chair in Diabetes Research, Juvenile Diabetes Research Foundation United States of America, Natural Sciences and Engineering Research Council of Canada

المصدر: Stem Cells ; volume 37, issue 4, page 516-528 ; ISSN 1066-5099 1549-4918

مصطلحات موضوعية: Cell Biology, Developmental Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1002/stem.2976Test
https://academic.oup.com/stmcls/article-pdf/37/4/516/42611462/stmcls_37_4_516.pdfTest

المؤلفون: Kuljanin, Miljan, Elgamal, Ruth M., Bell, Gillian I., Xenocostas, Dimetri, Xenocostas, Anargyros, Hess, David A., Lajoie, Gilles A.

المساهمون: JDRF USA Strategic Research Agreement on Optimizing β-cell Regeneration, Natural Sciences and Engineering Research Council of Canada

المصدر: Cell Reports ; volume 25, issue 9, page 2524-2536.e4 ; ISSN 2211-1247

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.celrep.2018.10.107Test
https://api.elsevier.com/content/article/PII:S2211124718317297?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211124718317297?httpAccept=text/plainTest

المؤلفون: Robertson, Catherine C, Elgamal, Ruth M, Henry-Kanarek, Belle A, Arvan, Peter, Chen, Shuibing, Dhawan, Sangeeta, Eizirik, Decio L, Kaddis, John S, Vahedi, Golnaz, Parker, Stephen C J, Gaulton, Kyle J, Soleimanpour, Scott A

المصدر: Mol Metab ; ISSN:2212-8778

العلاقة: https://doi.org/10.1016/j.molmet.2024.101973Test; https://pubmed.ncbi.nlm.nih.gov/38914291Test

الإتاحة: https://doi.org/10.1016/j.molmet.2024.101973Test
https://pubmed.ncbi.nlm.nih.gov/38914291Test