Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics
| العنوان: | Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics |
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| المؤلفون: | Anna Shtro, Marina Dukhinova, Polina Kuchur, Elena Kokinos, Alexey Komissarov |
| المصدر: | Cytokine & Growth Factor Reviews |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | TGFβ, Transforming growth factor beta, MIF, Macrophage migration inhibitory factor, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cellular Immunology, Monocytes, CCL, CC–chemokine ligand, MCP, Monocyte chemoattractant protein, Immunology and Allergy, Medicine, Macrophage, MRC, Mannose receptor C-type, IL, Interleukin, SNP, Single nucleotide polymorphisms, PAMP, Pathogen-associated molecular pattern, NFκB, Nuclear factor kappa-light-chain-enhancer of activated B cells, GWAS, Genome-wide association studies GWAS, IFN, Interferon, Cytokine, medicine.anatomical_structure, Cytokines, COPD, Chronic obstructive lung disorder, medicine.symptom, CD, Cluster of differentiation, TF, Transcription factor, TLR, Toll-like receptor, Immunology, Context (language use), Inflammation, TNFα, Tumor necrosis factor alpha, General Biochemistry, Genetics and Molecular Biology, Article, PPAR, Peroxisome proliferator-activated receptor, CCR, Cc chemokine receptor, EGFR, Epidermal growth factor receptor, PTX, Pentraxin-related protein, Humans, MՓ, Macrophage, RNA, Ribonucleic acid, ComputingMethodologies_COMPUTERGRAPHICS, MHC, Major histocompatibility complex, business.industry, SARS-CoV-2, STAT, Signal transducer and activator of transcription, Monocyte, Macrophages, COVID-19, Pneumonia, Single nucleotide polymorphisms, medicine.disease, LPS, Lipopolysaccharides, CXCL, Chemokine (C-X-C motif) ligand, GMCSF, Granulocyte-macrophage colony-stimulating factor, business, Cytokine storm, IRF, Interferon regulatory factor |
| الوصف: | Graphical abstract Macrophages represent the first line of anti-pathogen defense - they encounter invading pathogens to perform the phagocytic activity, to deliver the plethora of pro- and anti-inflammatory cytokines, and to shape the tissue microenvironment. Throughout pneumonia course, alveolar macrophages and infiltrated blood monocytes produce increasing cytokine amounts, which activates the antiviral/antibacterial immunity but can also provoke the risk of the so-called cytokine “storm” and normal tissue damage. Subsequently, the question of how the cytokine spectrum is shaped and balanced in the pneumonia context remains a hot topic in medical immunology, particularly in the COVID19 pandemic era. The diversity in cytokine profiles, involved in pneumonia pathogenesis, is determined by the variations in cytokine-receptor interactions, which may lead to severe cytokine storm and functional decline of particular tissues and organs, for example, cardiovascular and respiratory systems. Cytokines and their receptors form unique profiles in individual patients, depending on the (a) microenvironmental context (comorbidities and associated treatment), (b) lung monocyte heterogeneity, and (c) genetic variations. These multidisciplinary strategies can be proactively considered beforehand and during the pneumonia course and potentially allow the new age of personalized immunotherapy. |
| تدمد: | 1879-0305 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a702ed645dea7807089e0c4d5edaaeTest https://pubmed.ncbi.nlm.nih.gov/33342718Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3a702ed645dea7807089e0c4d5edaae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790305 |
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