دورية أكاديمية
Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV
| العنوان: | Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV |
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| المؤلفون: | Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson |
| المصدر: | HIV Research & Clinical Practice, Vol 24, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | integrase inhibitors, weight gain, people living with hiv, physical activity, population attributable fractions, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Background: Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. Methods: In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. Groups were matched for sex, age, baseline BMI and follow-up duration. Significant WG was defined as an increase of ≥5% from 1st visit weight over follow-up. PAFs and 95% CIs were estimated to quantify the proportion of the outcome that could be avoided if the risk factors were not present. Results: 118 PLWH switched to INSTI and 163 remained on current ART. Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. PAF for weight gain was the greatest for high BMI (45%, 95% CI: 27–59, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2578-7470 25787489 |
| العلاقة: | https://doaj.org/toc/2578-7470Test |
| DOI: | 10.1080/25787489.2022.2150815 |
| الوصول الحر: | https://doaj.org/article/7daac7e0979c4062a16fd479b6993927Test |
| رقم الانضمام: | edsdoj.7daac7e0979c4062a16fd479b6993927 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25787470 25787489 |
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| DOI: | 10.1080/25787489.2022.2150815 |