دورية أكاديمية
Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis
| العنوان: | Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis |
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| المؤلفون: | Seif el-Din, Sayed H, Dr., Hammam, Olfat A, Dr, Ezzat, Shahira M., Dr, Saleh, Samira, Prof.Dr., Safa, Marwa M, Dr., ElMaadawy, Walaa H, Dr, El-Lakkany, Naglaa M, Dr. |
| المصدر: | Pharmacy |
| بيانات النشر: | BUE Scholar |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Hydroxysafflor yellow A, Thioacetamide, Hepatic stellate cells, Inflammatory markers, Liver fibrosis, p21, α-SMA, Apoptosis |
| الوصف: | Objective: To evaluate the effect of hydroxysafflor yellow A (HSYA) on thioacetamide-induced liver fibrosis. Methods: Thioacetamide was administered to rats intraperitoneally in doses of 200 mg/kg twice a week for 12 weeks. Thioacetamide intoxicated rats were given silymarin (50 mg/kg) or HSYA (5 mg/ kg) orally every day for 8 weeks. Liver enzymes, fibrosis markers, histological changes as well as immunohistochemistry of TNF-α, IL-6, p21, α-SMA, and caspase-3 were examined. The effect of HSYA on HSC-T6 activation/proliferation and apoptosis was also determined in vitro. Results: HSYA decreased liver enzymes, TNF-α, IL-6, and p21 expressions, hepatic PDGF-B, TIMP-1, TGF-β1, and hydroxyproline levels, as well as fibrosis score (S2 vs. S4) compared to the thioacetamide group. HSYA also downregulated α-SMA while increasing caspase-3 expression. Surprisingly, at 500 µg/mL, HSYA had only a slightly suppressive effect on HSC proliferation, with a 9.5% reduction. However, it significantly reduced TGF-β1, inhibited α-SMA expression, induced caspase-3 expression, and promoted cell senescence. Conclusions: HSYA may be a potential therapeutic agent for delaying and reversing the progression of liver fibrosis. More research on HSYA at higher doses and for a longer period is warranted. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://buescholar.bue.edu.eg/pharmacy/712Test; https://buescholar.bue.edu.eg/context/pharmacy/article/1725/viewcontent/Hydroxysafflo_Yellow_Walaa.pdfTest |
| الإتاحة: | https://buescholar.bue.edu.eg/pharmacy/712Test https://buescholar.bue.edu.eg/context/pharmacy/article/1725/viewcontent/Hydroxysafflo_Yellow_Walaa.pdfTest |
| رقم الانضمام: | edsbas.4A5ADFF1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |