Immune evasion by cancer stem cells
| العنوان: | Immune evasion by cancer stem cells |
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| المؤلفون: | Goshi Shiota, Hiroyuki Tsuchiya |
| المصدر: | Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006 Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021) Regenerative Therapy |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | PD-L1/2, ligands 1/2, 0301 basic medicine, Medicine (General), Immune checkpoint inhibitors, Cell, LAG3, lymphocyte activation gene 3, Review, NK cells, Tumor initiation, HNSCC, head and neck squamous cell carcinoma, MIC, MHC class I polypeptide-related sequence, DC, dendritic cell, 0302 clinical medicine, AML, acute myeloid leukemia, ARID3B, AT-rich interaction domain-containing protein 3B, OCT4, octamer-binding transcription factor 4, TCR, T cell receptor, Cancer stem cells, Immune evasion, CCR7, C–C motif chemokine receptor 7, KDM4, lysine-specific demethylase 4C, medicine.anatomical_structure, TAM, tumor-associated macrophage, EMT, epithelial–mesenchymal transition, NK, natural killer, ULBP, UL16 binding protein, LILR, leukocyte immunoglobulin-like receptor, NGF, nerve growth factor, T cells, Biomedical Engineering, Treg, regulatory T cell, Tumor immunity, CTL, cytotoxic T lymphocytes, NOD, nonobese diabetic, Biomaterials, 03 medical and health sciences, R5-920, Immune system, ALDH, alcohol dehydrogenase, EV, extracellular vesicle, MDSC, myeloid-derived suppressor cell, Cancer stem cell, medicine, MHC, major histocompatibility complex, KIR, killer immunoglobulin-like receptor, TAP, transporter associated with antigen processing, SCID, severe combined immunodeficient, QH573-671, business.industry, LMP, low molecular weight protein, CIK, cytokine-induced killer cell, LOX, lysyl oxidase, CTLA-4, cytotoxic T-cell-associated antigen-4, CMV, cytomegalovirus, SOX2, sex determining region Y-box 2, NSG, NOD/SCID IL-2 receptor gamma chain null, Evasion (ethics), CSC, cancer stem cell, 030104 developmental biology, DNMT, DNA methyltransferase, Cancer cell, Immune checkpoints, Cancer research, PI9, protease inhibitor 9, ADCC, antibody-dependent cell mediated cytotoxicity, uPAR, urokinase-type plasminogen activator receptor, Cytology, business, ETO, fat mass and obesity associated protein, 030217 neurology & neurosurgery, PD-1, programmed death receptor-1, PSME3, proteasome activator subunit 3, Developmental Biology |
| الوصف: | Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, the clinical efficacy of these treatments requires further improvement. The mechanisms through which cancer cells escape the immune response must be identified and clarified. Cancer stem cells (CSCs) play a central role in multiple aspects of malignant tumors. CSCs can initiate tumors in partially immunocompromised mice, whereas non-CSCs fail to form tumors, suggesting that tumor initiation is a definitive function of CSCs. However, the fact that non-CSCs also initiate tumors in more highly immunocompromised mice suggests that the immune evasion property may be a more fundamental feature of CSCs rather than a tumor-initiating property. In this review, we summarize studies that have elucidated how CSCs evade tumor immunity and create an immunosuppressive milieu with a focus on CSC-specific characteristics and functions. These profound mechanisms provide important clues for the development of novel tumor immunotherapies. Highlights • Cancer stem cells (CSCs) play a central role in multiple aspects of malignant tumors. • Immune evasion is a fundamental feature of CSCs. • Immune evasion mechanisms must be precisely clarified to improve tumor immunotherapy. • CSCs are promising targets for tumor immunotherapy. |
| وصف الملف: | application/pdf |
| تدمد: | 2352-3204 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6054a82a446a6f8b0b1100401e59a6Test https://doi.org/10.1016/j.reth.2021.02.006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4f6054a82a446a6f8b0b1100401e59a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523204 |
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