نتائج البحث - "ERK inhibitors"

العلاقة: The authors also thank 3-MET Society for providing Prof Ashraf A. Aly, one-month fellowship enabling him to carry out the compounds analysis in Karlsruhe Institute of Technology, Karlsruhe, Germany. We also acknowledge the NCI for inclusion of our compounds in their screening program. Funding by The Cancer Prevention and Research Institute of Texas grant (RP160657), the National Institutes of Health (R01 GM123252) and The Welch Foundation (F-1390) to K.N. Dalby is also acknowledged. The computational work was completed in part with resources supported by the Science and Technology Development Fund, STDF, Egypt.; Aly , A A , El-Sheref , E M , Bakheet , M E M , Mourad , M A E , Bräse , S , Ibrahim , M A A , Nieger , M , Garvalov , B K , Dalby , K N & Kaoud , T S 2019 , ' Design, synthesis and biological evaluation of fused naphthofuro[3,2-c]quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma ' , Bioorganic Chemistry , vol. 82 , pp. 290-305 . https://doi.org/10.1016/j.bioorg.2018.10.044Test; ORCID: /0000-0003-1677-0109/work/53512577; 85055910927; 054adecd-90ec-487a-b4da-63da64716d68; http://hdl.handle.net/10138/325574Test; 000455479600032

الإتاحة: http://hdl.handle.net/10138/325574Test

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5

دورية أكاديمية

Multi-Target Chemometric Modelling, Fragment Analysis and Virtual Screening with ERK Inhibitors as Potential Anticancer Agents

المؤلفون: Amit Kumar Halder, Amal Kanta Giri, Maria Natália Dias Soeiro Cordeiro

المصدر: Molecules; Volume 24; Issue 21; Pages: 3909

مصطلحات موضوعية: ERK inhibitors, QSAR, multi-target models, fragment analysis, virtual screening, molecular docking, molecular dynamics, binding free energy

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules24213909Test

الإتاحة: https://doi.org/10.3390/molecules24213909Test

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6

دورية أكاديمية

Targeting the ERK Signaling Pathway in Melanoma

المؤلفون: Paola Savoia, Paolo Fava, Filippo Casoni, Ottavio Cremona

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 6; Pages: 1483

مصطلحات موضوعية: ERK pathway, target therapy, metastatic melanoma, BRAF inhibitors, MEK inhibitors, ERK inhibitors, NRAS inhibitors, melanoma treatment

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms20061483Test

الإتاحة: https://doi.org/10.3390/ijms20061483Test

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7

Anti‑oncogenic and pro‑myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcoma

المؤلفون: Agnese, Di Rocco, Simona, Camero, Anna, Benedetti, Biliana, Lozanoska-Ochser, Francesca, Megiorni, Cinzia, Marchese, Lorenzo, Stramucci, Carmela, Ciccarelli, Marina, Bouché, Gianluca, Bossi, Francesco, Marampon, Bianca Maria, Zani

مصطلحات موضوعية: Mitogen-Activated Protein Kinase Kinases, embryonal rhabdomyosarcoma, MEK/ERK inhibitors, MKK6, p38, Myc, Cancer Research, Cell Differentiation, General Medicine, p38 Mitogen-Activated Protein Kinases, Oncology, Cell Line, Tumor, Humans, Rhabdomyosarcoma, Embryonal, Child, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e4cfd12be0c2cdab030dd6659f2fceTest
http://hdl.handle.net/11573/1651173Test

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دورية أكاديمية

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer

المؤلفون: Oddo D, Sennott EM, Barault L, Valtorta E, Arena S, Cassingena A, Filiciotto G, Marzolla G, Elez E, van Geel RM, Bartolini A, Crisafulli G, Boscaro V, Godfrey JT, Buscarino M, Cancelliere C, Linnebacher M, Corti G, Truini M, Siravegna G, Grasselli J, Gallicchio M, Bernards R, Schellens JH, Tabernero J, Engelman JA, Sartore-Bianchi A, Bardelli A, Siena S, Corcoran RB, Di Nicolantonio F.

المساهمون: Oddo, D, Sennott, Em, Barault, L, Valtorta, E, Arena, S, Cassingena, A, Filiciotto, G, Marzolla, G, Elez, E, van Geel RM, Bartolini, A, Crisafulli, G, Boscaro, V, Godfrey, Jt, Buscarino, M, Cancelliere, C, Linnebacher, M, Corti, G, Truini, M, Siravegna, G, Grasselli, J, Gallicchio, M, Bernards, R, Schellens, Jh, Tabernero, J, Engelman, Ja, Sartore-Bianchi, A, Bardelli, A, Siena, S, Corcoran, Rb, Di Nicolantonio, F.

مصطلحات موضوعية: BRAF, colorectal cancer, drug resistance, cetuximab, ERK inhibitors

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27312529; info:eu-repo/semantics/altIdentifier/wos/WOS:000382295300020; volume:76; issue:15; firstpage:4504; lastpage:4515; numberofpages:12; journal:CANCER RESEARCH; info:eu-repo/grantAgreement/EC/FP7/602901; http://hdl.handle.net/2318/1569569Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84982684991; http://cancerres.aacrjournals.org/content/76/15/4504.longTest

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-16-0396Test
http://hdl.handle.net/2318/1569569Test
http://cancerres.aacrjournals.org/content/76/15/4504.longTest

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9

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

المساهمون: MUMC+: DA KFT Laboratorium (9), RS: FHML non-thematic output

المصدر: Cancer Research
Cancer Research, 76(15), 4504-4515. American Association for Cancer Research Inc.

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, 0301 basic medicine, MAPK/ERK pathway, Cancer Research, endocrine system diseases, Colorectal cancer, medicine.medical_treatment, Gene Dosage, colorectal cancer, Drug resistance, medicine.disease_cause, Article, BRAF, ERK inhibitors, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, cetuximab, medicine, Humans, neoplasms, EGFR inhibitors, drug resistance, Cetuximab, business.industry, BRAF, colorectal cancer, drug resistance, cetuximab, ERK inhibitors, Gene Amplification, Cancer, medicine.disease, digestive system diseases, 3. Good health, 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, KRAS, Colorectal Neoplasms, business, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b75892ae1f547d111434229a042c4aTest
https://cris.maastrichtuniversity.nl/en/publications/d6475322-dc21-4472-a221-427cede7b2e7Test

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Design, synthesis and biological evaluation of fused naphthofuro[3,2-c]quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma

المؤلفون: Momtaz E. M. Bakheet, Mai A.E. Mourad, Mahmoud A. A. Ibrahim, Martin Nieger, Essmat M. El-Sheref, Tamer S. Kaoud, Boyan K. Garvalov, Ashraf A. Aly, Kevin N. Dalby, Stefan Bräse

المساهمون: Department of Chemistry

مصطلحات موضوعية: MAPK/ERK pathway, NCI-60 panel, 116 Chemical sciences, PROTEIN, Apoptosis, Tumor initiation, Quinolones, 01 natural sciences, Biochemistry, GTP Phosphohydrolases, ERK inhibitors, ACTIVATION, Catalytic Domain, Drug Discovery, DOCKING, PHOSPHORYLATION, Melanoma, Mitogen-Activated Protein Kinase 1, 0303 health sciences, Mitogen-Activated Protein Kinase 3, Molecular Structure, Kinase, Chemistry, Naphthafuro-quinoline, BRAF mutant, 3. Good health, BVD-523, Proto-Oncogene Proteins B-raf, Antineoplastic Agents, Article, Naphthafuro-pyranoquinoline, 03 medical and health sciences, Structure-Activity Relationship, Cell Line, Tumor, medicine, Humans, Furans, Molecular Biology, Protein Kinase Inhibitors, 030304 developmental biology, Pyrans, Dose-Response Relationship, Drug, 010405 organic chemistry, Organic Chemistry, Membrane Proteins, IN-VITRO, medicine.disease, In vitro, 0104 chemical sciences, PRODUCTS, Docking (molecular), Cell culture, DISCOVERY, Mutation, Cancer research, 1182 Biochemistry, cell and molecular biology, Drug Screening Assays, Antitumor, QUINONES, Naphthoquinones, ACQUIRED-RESISTANCE

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecdc0336ec22edd17175f0dbd110ad7Test
http://hdl.handle.net/10138/325574Test

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