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المؤلفون: Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L. Kim, Jason S. Pierce, Besim Ogretmen, Anthony H. Futerman, Frank Thévenod
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: TG, thapsigargin, Male, cancer drug resistance, FASN, fatty acid synthase, Biochemistry, ERAD, ER-associated degradation, UPR, unfolded protein response, MDR, multidrug resistance, Tandem Mass Spectrometry, Sphingosine N-Acyltransferase, Tumor Microenvironment, HERPUD1, homocysteine-inducible ER protein with ubiquitin-like domain 1, GRP78, glucose-regulated protein 78 kDa, unfolded protein response, Endoplasmic Reticulum-Associated Degradation, Kidney Neoplasms, XBP1, X-box binding protein 1, lipids (amino acids, peptides, and proteins), Female, ABC transporter, ATP6α, activating transcription factor 6α, Research Article, ATP Binding Cassette Transporter, Subfamily B, PDIA4, protein disulfide isomerase family A member 4, P-glycoprotein, CHOP, C/EBP homologous protein, Ceramides, ACACA, acetyl-CoA carboxylase alpha, ER, endoplasmic reticulum, VLC, very long chain, LCC, long-chain ceramide, HPCT, human proximal convoluted tubule, Humans, RNA, Messenger, TUN, tunicamycin, Molecular Biology, Sphingolipids, SM, sphingomyelin, UCSC, University of California, Santa Cruz, SREBP, sterol-regulatory element binding protein, LD, lipid domain, Tumor Suppressor Proteins, Membrane Proteins, Cell Biology, DOX, doxorubicin, Doxorubicin, Drug Resistance, Neoplasm, Mff, mitochondrial fission factor, CerS, ceramide synthase, HMGCL, 3-hydroxymethyl-3-methylglutaryl-CoA lyase, TM, transmembrane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1819640a96f5d4d5386b5634e205d7Test
http://europepmc.org/articles/PMC8804196Test -
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المؤلفون: Rohit Sharma, Jarin T. Snyder, Laura C. Alonso
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 27, Iss, Pp S69-S80 (2019)مصطلحات موضوعية: 0301 basic medicine, lcsh:Internal medicine, Programmed cell death, Cell type, Bcl-2, B-cell lymphoma 2, Cell Survival, Activating transcription factor 6, Replication, 030209 endocrinology & metabolism, Apoptosis, Cell Count, Review, Jnk, c-Jun N-terminal kinase, mTor, mammalian target of rapamycin, Cell fate determination, Biology, medicine.disease_cause, S1P, site 1 protease, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, Atf6α, Activating transcription factor alpha, medicine, Animals, Humans, cFos, human homolog of Finkel–Biskis–Jinkins murine osteogenic sarcoma virus oncogene, ERAD, ER associated degradation, Pancreatic beta cell, lcsh:RC31-1245, Molecular Biology, Cell Proliferation, S2P, site 2 protease, Cell Death, Rheb, Ras homolog, mTor binding, Chop, C/EBP homologous protein, Cell Biology, Cell cycle, Vegf, Vascular endothelial growth factor, 030104 developmental biology, Secretory protein, Unfolded protein response, Beta cell, Carcinogenesis, Runx2, Runt-related transcription factor 2, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aa24f685d0adce07b3a208b6f3cbf5Test
http://europepmc.org/articles/PMC6768497Test -
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المؤلفون: Fausto A. Varela, Kimberley E. Sala-Hamrick, Jacob R. Mackinder, Karin List, Andrew S. Murray, Carly E. Martin, Evan C. Harrison, Joseph G. Lundgren
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: serine protease, TMPRSS13, ERAD, ER-associated degradation system, Biochemistry, GPI, glycophosphatidylinositol, chemistry.chemical_compound, SRCR, scavenger receptor cysteine rich, TTSP, type II transmembrane serine protease, N-linked glycosylation, L, lipoprotein receptor class A, Chlorocebus aethiops, Cellular localization, Enzyme Precursors, biology, Chemistry, phosphorylation, type II transmembrane serine protease, Serine Endopeptidases, cell surface protein, Cell biology, HAI-2, Protein Transport, COS Cells, Phosphorylation, lipids (amino acids, peptides, and proteins), PNGase F, peptide:N-glycosidase F, Research Article, Glycosylation, Protein domain, macromolecular substances, HMW, high molecular weight, HAI, hepatocyte growth factor activator inhibitor, protease inhibitor, ER, endoplasmic reticulum, PCSK6, proprotein convertase subtilisin/kexin-6, Protein Domains, Zymogen, Animals, Humans, Molecular Biology, TTSP, Serine protease, SP, serine protease, KLK, kallikrein-related peptidase, Cell Membrane, Membrane Proteins, Cell Biology, MSPL, mosaic serine protease large-form, PI-PLC, phosphatidylinositol-specific phospholipase C, carbohydrates (lipids), HEK293 Cells, Zymogen activation, Proteolysis, biology.protein, HGF, hepatocyte growth factor, Protein Processing, Post-Translational, TM, transmembrane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f496da9b03bc8b4f22e362d41f685527Test
http://europepmc.org/articles/PMC8503615Test -
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المؤلفون: Bénédicte, Gaborit, Roland, Govers, Alexandre, Altié, Jean Michel, Brunel, Pierre, Morange, Franck, Peiretti
المساهمون: Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Membranes et cibles thérapeutiques (MCT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA), Service de Santé des Armées, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Brunel, Jean Michel
المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
Journal of Biological Chemistry, 2021, 297 (1), pp.100818. ⟨10.1016/j.jbc.2021.100818⟩
The Journal of Biological Chemistryمصطلحات موضوعية: O-GlcNacylation, HFD, high-fat diet, autophagy, Glycosylation, BACE1, β-secretase 1, ERLAD, ER-to-lysosome-associated degradation, liver, Models, Biological, Diabetes Mellitus, Experimental, ERAD, ER-associated degradation, ER, endoplasmic reticulum, APP, amyloid precursor protein, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, mental disorders, Animals, Aspartic Acid Endopeptidases, Humans, insulin receptor, BAF, Bafilomycin A1, TGN, trans Golgi network, Secretory Pathway, beta-secretase 1 (BACE1), Cholestanes, AD, Alzheimer disease, diabetes, Ubiquitin, Ubiquitination, PC, proprotein convertase, Hep G2 Cells, Endoplasmic Reticulum Stress, Receptor, Insulin, Disease Models, Animal, HEK293 Cells, proteasome, ESP, early secretory pathway, IR, insulin receptor, Proteolysis, Proteostasis, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, lysosome, Spermine, PTM, posttranslational modification, Amyloid Precursor Protein Secretases, HBP, hexosamine biosynthetic pathway, Protein Binding, Research Article
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d438b123de19467c77e8e9b4739301bbTest
https://hal.archives-ouvertes.fr/hal-03368302Test -
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المؤلفون: Juncheng Wei, Emilio P Mottillo, Hyunbae Kim, Jiandie D. Lin, Xuequn Chen, Kezhong Zhang, Lobelia Samavati, Deyu Fang, Ren Zhang, Zhenfeng Song, Bhanu P. Jena, Li Li
المصدر: Molecular Metabolism, Vol 49, Iss, Pp 101192-(2021)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, BOH, beta-hydroxybutyrate, ATG7, autophagy-related protein 7, ERAD, ER-associated degradation, ER-associated degradation, Mice, UPR, unfolded protein response, 0302 clinical medicine, Ubiquitin, Transcriptional regulation, LC3, microtubule-associated protein 1A/1B-light chain 3, Cyclic AMP Response Element-Binding Protein, Internal medicine, TG, triglyceride, biology, Chemistry, Fatty Acids, ARNTL Transcription Factors, Circadian Rhythm, HRD1, HMG-CoA reductase degradation 1 homolog, Sel1L, SEL1L adaptor subunit of ERAD E3 ubiquitin ligase, Ubiquitin ligase, Cell biology, Liver, BMAL1, aryl hydrocarbon receptor nuclear translocator-like protein 1, Original Article, Circadian metabolism, Lipolysis, Ubiquitin-Protein Ligases, 030209 endocrinology & metabolism, Protein degradation, Endoplasmic-reticulum-associated protein degradation, ER, endoplasmic reticulum, G6PC, glucose-6-phosphatase catalytic subunit, 03 medical and health sciences, CREBH, cAMP-responsive element-binding protein, hepatic-specific, Autophagy, Animals, PPAR alpha, Circadian rhythm, Molecular Biology, Triglycerides, BMAL1, brain and muscle ARNT-Like 1, PPARα, peroxisome proliferator-activated receptor α, PPARα, peroxisome proliferator–activated receptor α, KO, knockout, Gluconeogenesis, Ubiquitination, Lipid metabolism, Cell Biology, CTL, control, RC31-1245, Mice, Inbred C57BL, 030104 developmental biology, Nuclear receptor, FA, fatty acids, Proteolysis, biology.protein, PCK1, phosphoenolpyruvate carboxykinase 1, Endoplasmic reticulum
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb90729ce4a8ed907b485978d3c3aadTest
http://www.sciencedirect.com/science/article/pii/S2212877821000326Test -
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المصدر: Biotechnology Advances 37 (2019) 5
Biotechnology Advances
Biotechnology Advances, 37(5), 642-666مصطلحات موضوعية: 0106 biological sciences, GRAS, generally recognized as safe, Bio Process Engineering, PDI, protein disulfide isomerase, ITC, inverse transition cycling, medicine.disease_cause, Protein Engineering, 01 natural sciences, Applied Microbiology and Biotechnology, Protein-based polymers, Pichia, law.invention, ERAD, ER-associated degradation, P4H, peptidyl-prolyl-4-hydroxylase, UPR, unfolded protein response, Pichia pastoris, law, chemistry.chemical_classification, 0303 health sciences, biology, BiP, immunoglobulin-binding protein, Polymer, Self-assembly, OD600, optical density at 600 nm, Pho1, acid phosphatase, Block copolymers, Recombinant Proteins, AOX1, alcohol oxidase 1, Amino acid, ECM, extracellular matrix, Biochemistry, MaSp1, major ampullate spidroin 1, ppαF, Saccharomyces cerevisiae α-factor mating pheromone prepro peptide, EBP, elastin-binding protein, ELP, elastin-like polypeptide, Recombinant DNA, Collagen, GAP, glyceraldehyde-3-phosphate dehydrogenase, Biotechnology, LCST, lower critical solution temperature, Materials science, his4, histidinol dehydrogenase, Silk, Bioengineering, Article, 03 medical and health sciences, Industrial Microbiology, 010608 biotechnology, DPAPase A, dipeptidyl aminopeptidase A, Bioreactor, medicine, Bioprocess, Escherichia coli, 030304 developmental biology, MaSp2, major ampullate spidroin 2, biology.organism_classification, Yeast, Elastin, BBP Bioconversion, chemistry, FDA, food and drug administration, Proteolysis, Gelatin, Protein expression, Physical Chemistry and Soft Matter
وصف الملف: application/pdf; application/octet-stream
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38288728552ecae41f32d9750732c57aTest
https://doi.org/10.1016/j.biotechadv.2019.03.012Test -
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المؤلفون: Darren R. Heintzman, Jonathan P. Schlebach, Madison T. Wright, Katherine R. Clowes, Justin T. Marinko, Lars Plate, Charles R. Sanders
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Glycosylation, peripheral neuropathy, Protein Conformation, peripheral myelin protein 22 (PMP22), EMC, ER membrane protein complex, Mutant, Charcot–Marie–Tooth disease (CMTD), Biochemistry, ERAD, ER-associated degradation, N-linked glycosylation, ERQC, ER quality control network, ER quality control, OST, oligosaccharyltransferase, Chemistry, gRNA, guide RNA, Cell biology, Protein Transport, PM, plasma membrane, Myelin Proteins, Research Article, Endoplasmic-reticulum-associated protein degradation, ER, endoplasmic reticulum, 03 medical and health sciences, FBS, fetal bovine serum, trafficking, Calnexin, Humans, CMTD, Charcot–Marie–Tooth disease, RER1, retention in ER sorting receptor 1, RSC, rat Schwann cell, ER membrane protein complex, Molecular Biology, CNX, calnexin, GO, gene ontology, 030102 biochemistry & molecular biology, co-IP, coimmunoprecipitation, Endoplasmic reticulum, Oligosaccharyltransferase, PMP22, peripheral myelin protein 22, TMT, tandem mass tag, Cell Biology, Adaptor Proteins, Vesicular Transport, 030104 developmental biology, HEK293 Cells, Membrane protein, Mutation, PNS, peripheral nervous system, DMEM, Dulbecco’s modified Eagle medium, TM, transmembrane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f7aa822492ff0debb73ba9d1a8ad87Test
https://pubmed.ncbi.nlm.nih.gov/33933451Test -
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المؤلفون: Michelle Y. Fry, Shyam M. Saladi, William M. Clemons, Ku-Feng Lin
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cellular homeostasis, TMD, transmembrane domain, Sti1, medicine.disease_cause, Endoplasmic Reticulum, Biochemistry, ERAD, ER-associated degradation, Protein targeting, Integral membrane protein, Heat-Shock Proteins, Signal recognition particle, Fungal protein, Chemistry, Hop, GET, guided entry of tail-anchored protein, SGTA, small glutamine tetratricopeptide repeat protein alpha, Transmembrane domain, UBL, ubiquitin-like domain, Protein Binding, Research Article, cochaperones, Saccharomyces cerevisiae Proteins, TA, tail-anchored, Saccharomyces cerevisiae, Endoplasmic-reticulum-associated protein degradation, SRP, signal recognition particle, ER, endoplasmic reticulum, 03 medical and health sciences, medicine, protein targeting, Humans, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, tail-anchored proteins, Molecular Biology, IMP, integral membrane protein, TRC, transmembrane recognition complex, 030102 biochemistry & molecular biology, Ubiquitin, MLP, mislocalized membrane protein, C-terminus, Cell Membrane, Membrane Proteins, Cell Biology, 030104 developmental biology, PMSF, phenylmethylsulfonyl fluoride, BPA, p-benzoyl-l-phenylalanine, Biophysics, Protein Multimerization, Carrier Proteins, Molecular Chaperones
وصف الملف: application/pdf; application/vnd.ms-excel
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83ce878dc24df6e9c96eec46dad7f8fTest
https://pubmed.ncbi.nlm.nih.gov/33610544Test -
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المؤلفون: Marioara Chirițoiu, Simona Ghenea, Gabriela N. Chirițoiu, Andrei-Jose Petrescu, Stefana M. Petrescu, Cristian V.A. Munteanu
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: Proteomics, UGGT, Endoplasmic Reticulum, Biochemistry, ERLEC1, ER lectin 1, Analytical Chemistry, ERAD, ER-associated degradation, MAN1B1, mannosyl-oligosaccharide 1,2-alpha-mannosidase, PCDH2, protocadherin 2, TXNDC11, thioredoxin domain–containing protein 11, EDEM2, ER degradation–enhancing α-mannosidase-like protein 2, ER quality control, Glycomics, Melanoma, FA, formic acid, DMEM, Dulbecco's modified Eagle's medium, EndoH, endo-β-N-acetylglucosaminidase H, HCD, higher collisional dissociation, gpERAD, glycoprotein ERAD, Cell biology, N-glycoFASP, N-glyco filter–aided sample preparation, TRP-1, melanoma antigen gp75, WB, Western blot, SEL1L, protein sel-1 homolog 1, Proteome, ON, overnight, RT, room temperature, TMX, thioredoxin transmembrane member, CANX, calnexin, PSM, peptide spectrum match, GluC, glucosidase C, E2D, plasmid encoding the C terminus missing EDEM2, FDR, false discovery rate, Protein Sel-1 Homolog 1, AE, affinity enrichment, Endoplasmic-reticulum-associated protein degradation, Biology, siScr, noncoding RNA sequence, scramble, ER, endoplasmic reticulum, cDNA, complementary DNA, alpha-Mannosidase, Calnexin, Cell Line, Tumor, RES, relative evolution score, GO, Gene Ontology, Humans, glycoproteomics, CCDC47, coiled-coil domain–containing protein 47, ITGA1, integrin alpha-1, siEDEM2, siRNA sequence targeting EDEM2, Molecular Biology, Glycoproteins, SAINT, significance analysis of interactome, ERQC, endoplasmic reticulum quality-control, HLA, human leukocyte antigen, Endoplasmic reticulum, Research, LFQ, label-free quantification, MS, ERAD, ACN, acetonitrile, Label-free quantification, pulsed-SILAC, UGGT, uridine diphosphate–glucose:glycoprotein glucosyltransferase, pSILAC, pulse stable isotope labeling with amino acids in cell culture, EDEM2, NSC, normalized spectral count, DNAJB12, DnaJ homolog subfamily B member 12, DERL1, Derlin-1, HA, hemagglutinin, LBB, lectin-binding buffer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00203f941821c97c93215890a483b51Test
https://pubmed.ncbi.nlm.nih.gov/34332121Test -
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المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Apoptosis, medicine.disease_cause, Endoplasmic Reticulum, Biochemistry, ERAD, ER-associated degradation, endoplasmic reticulum associated protein degradation (ERAD), UPR, unfolded protein response, ATP1A3, 4-phenylbutyrate (4PBA), protein misfolding, Phosphorylation, unfolded protein response (UPR), BAD, Bcl-2 agonist of cell death, Mutation, Chemistry, Na+/K+-ATPase, tet, tetracycline, ER retention, Cell biology, subcellular fractionation, Protein Transport, eukaryotic initiation factor 2alpha (eIF2 α), Sodium-Potassium-Exchanging ATPase, Research Article, Signal Transduction, N-linked glycosylation, SDS, sodium dodecyl sulfate, Protein subunit, eIF2α, eukaryotic initiation factor 2α, Endoplasmic-reticulum-associated protein degradation, ER, endoplasmic reticulum, 03 medical and health sciences, genetic disease, 4PBA, 4-phenylbutyrate, also known clinically as Buphenyl, medicine, Humans, IRE1α, serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1α, a dual-function transmembrane ER receptor, Molecular Biology, XBP1s, X-box binding protein 1, spliced form, a transcription factor, 030102 biochemistry & molecular biology, Endoplasmic reticulum, Cell Biology, 030104 developmental biology, HEK293 Cells, Unfolded protein response, Unfolded Protein Response, endoplasmic reticulum stress (ER stress)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b84f0e296198a9bf694f744e12b710dTest
http://europepmc.org/articles/PMC7949067Test