Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study
| العنوان: | Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study |
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| المؤلفون: | Kyung Hwan Shin, Yong Bae Kim, Jinhyun Choi, Sei One Shin, Jung Ho Im, Chang Ok Suh, Yeon Joo Kim, Haeyoung Kim, Sea Won Lee, Dong Soo Lee, Jee Suk Chang, Seung Yeun Chung, Ik Jae Lee, Jihye Cha, Kyu Chan Lee, Won Sup Yoon, Boram Ha, Sun Young Lee, Jeongshim Lee, Sung Ja Ahn, Jinhee Kim, Mi Young Kim, Won Soon Park, Jin Hwa Choi, Kyubo Kim, Jin Ho Kim |
| المصدر: | The Breast : Official Journal of the European Society of Mastology Breast, Vol 56, Iss, Pp 7-13 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Multivariate analysis, EQD2, equivalent dose in 2 Gy fractions, medicine.medical_treatment, Mammaplasty, Context (language use), Breast Neoplasms, Major complication, Radiation Dosage, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, PMRT, post-mastectomy radiotherapy, OD, odds ratio, Clinical endpoint, Medicine, Humans, Breast reconstruction, HER2, human epidermal growth factor receptor 2, 030212 general & internal medicine, Mastectomy, Aged, Retrospective Studies, RT, Radiotherapy, MROC, Mastectomy Reconstruction Outcomes Consortium, business.industry, General Medicine, Odds ratio, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Confidence interval, Radiation therapy, CI, confidence interval, Treatment Outcome, 030220 oncology & carcinogenesis, Surgery, Original Article, Female, Radiotherapy, Adjuvant, Radiology, Dose Fractionation, Radiation, business |
| الوصف: | Purpose Emerging data suggest that higher radiation doses in post-mastectomy radiotherapy may be associated with an increased risk of reconstruction complications. This study aimed to validate previous findings regarding the impact of radiation dose on complications among women with breast cancer using a multi-center dataset. Methods Fifteen institutions participated, and women with breast cancer who received radiotherapy after either autologous or prosthetic breast reconstruction were included. The primary endpoint was major post-radiation therapy complications requiring re-operation for explantation, flap failure, or bleeding control. Results In total, 314 patients were included. Radiotherapy was performed using both conventional fractionation and hypofractionation in various schedules. The range of the radiation therapy dose in Equivalent Dose in 2 Gy fractions (EQD2; α/β = 3.5) varied from 43.4 to 71.0 Gy (median dose: 48.6 Gy). Boost radiation therapy was administered to 49 patients. Major post-radiation therapy complications were observed in 24 (7.6%) patients. In multivariate analysis, an increasing EQD2 per Gy (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.26–1.98; p Highlights • Radiation dose is associated with the risk of breast reconstruction complications. • We conducted a retrospective multi-center observational study of 314 women in Korea. • Complication-related risk factors were identified using multivariate analysis. • Use of hypofractionated radiation therapy may improve breast reconstruction outcomes. • A prospective multi-center study is under way to further validate our findings. |
| اللغة: | English |
| تدمد: | 1532-3080 0960-9776 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961e1d4c717830d89e8ba42c835fe7deTest http://europepmc.org/articles/PMC7848800Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....961e1d4c717830d89e8ba42c835fe7de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15323080 09609776 |
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