نتائج البحث - "ECL, extracellular loop"

1

A two-stage computational approach to predict novel ligands for a chemosensory receptor

المؤلفون: Amara Jabeen, Ramya Vijayram, Shoba Ranganathan

المصدر: Current Research in Structural Biology
Current Research in Structural Biology, Vol 2, Iss, Pp 213-221 (2020)

مصطلحات موضوعية: Hydrophobicity correspondence, MD, Molecular dynamics, Virtual ligand screening, SSD, Sum of squared difference, HMDB, Human metabolome database, Atomic property field, Binding free energy calculation, Computational biology, Molecular dynamics, RMSF, Root mean square fluctuation, PMEMD, Particle-Mesh Ewald Molecular Dynamics, Article, RMSD, Root mean square deviation, MMGBSA, Molecular mechanics generalized born surface area, Structural Biology, LBVS, Ligand based virtual screening, medicine, Olfactory receptor, Homology modeling, Receptor, Molecular Biology, lcsh:QH301-705.5, G protein-coupled receptor, HCMV, Human cytomegalovirus, Virtual screening, CSF, Cerebrospinal fluid, Chemistry, LC, Lung carcinoids, ECL, Extracellular loop, NAFLD, Non-alcoholic fatty liver disease, Small molecule, GPCR, G protein coupled receptor, APF, Atomic property field, MMPBSA, Molecular mechanics Poisson–Boltzmann surface area, medicine.anatomical_structure, lcsh:Biology (General), OR, olfactory receptor, POPC, 1-palmitoyl-2-oleoyl-sn-glycero- 3-phosphatidylcholine, Pharmacophore, OR1A2, SBVS, Structure based virtual screening, Amber, Assisted model Building with Energy Refinement, TM, Transmembrane, NASH, Nonalcoholic steatohepatitis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4aaf6d8e00bcaee8f8664f674f2cd30Test
http://europepmc.org/articles/PMC8244491Test

2

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

المؤلفون: Celine Valant, Patrick M. Sexton, Elham Khajehali, Peter J. Scammells, Manuela Jörg, Craig W. Lindsley, Arthur Christopoulos, Andrew B. Tobin, P. Jeffrey Conn

المصدر: Biochemical Pharmacology

مصطلحات موضوعية: WT, wild type, 0301 basic medicine, PF-06767832, N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-(4-(thiazol-4-yl)benzyl)pyridine-2-carboxamide, Cooperativity, Biochemistry, Muscarinic acetylcholine receptor, Cricetinae, TM, transmembrane domain, BQCA, benzylquinolone carboxylic acid, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Allosteric modulation, MIPS1780, 3-(2-hydroxycyclohexyl)-6-(2-((4-(1-methyl-1H-pyrazol-4-yl)- benzyl)oxy)phenyl)pyrimidin-4(3H)-one, ANOVA, analysis of variance, Drug discovery, Chemistry, PBZ, phenoxybenzamine, 3. Good health, PAM, positive allosteric modulator, BQZ-12, 3-((1S,2S)-2-hydroxycyclohexyl)-6-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)benzo [h]-quinazolin-4(3H)-one, medicine.symptom, Allosteric Site, Allosteric modulator, DMEM, Dulbecco modified eagle medium, Allosteric regulation, PBS, phosphate-buffered saline, BQCA, CHO Cells, ECL, extracellular loop, Cholinergic Agonists, Muscarinic Agonists, AD, Alzheimer’s disease, CHO, Chinese hamster ovary, Article, NMS, N-methylscopolamine, 03 medical and health sciences, Cricetulus, FBS, fetal bovine serum, Allosteric Regulation, medicine, Animals, Humans, mAChR, muscarinic acetylcholine receptor, Binding site, GPCR, G protein-coupled receptor, ComputingMethodologies_COMPUTERGRAPHICS, NAM, negative allosteric modulator, Pharmacology, IP1, inositol monophosphate, Binding Sites, Dose-Response Relationship, Drug, ACh, acetylcholine, Receptor, Muscarinic M1, VU6004256 (4, 6-difluoro-N-(1S,2S)-2-hydroxycyclohexyl-1-((6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-yl)methyl)-1H-indole-3-carboxamide, Rational design, Acetylcholine, 030104 developmental biology, Mechanism of action, Mutagenesis, HBSS, Hanks’ balanced salt solution, Biophysics, BSA, bovine serum albumin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825fb21ad2045775ecf4d26ab83b0c2Test
https://eprints.gla.ac.uk/163141/1/163141.pdfTest

3

Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue

المؤلفون: Lauren E. Heusinkveld, Jaclyn M. Kline, Sergio M. Pontejo, Eleanor Taranto, Kyoungin Cho, Isabel J. Hsu, Jaspal S. Khillan, Philip M. Murphy, Alessandra G. Tomasi, Clare B. Martin

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, 0301 basic medicine, CCR1, Chemokine, cell migration, CCR3, Ligands, Biochemistry, Receptors, G-Protein-Coupled, Mice, Chemokine receptor, FACS, fluorescence-activated cell sorting, TM, transmembrane domain, ACKR, atypical chemokine receptor, Ccr1l1, Ccr1-like 1, BMDM, bone marrow-derived macrophages, chemotaxis, Mice, Knockout, biology, Chemistry, tyrosine sulfation, Cell biology, Chemotaxis, Leukocyte, CCL9, Chemokines, CC, Female, Receptors, Chemokine, Chemokines, BMDE, bone marrow-derived eosinophils, Protein Binding, Signal Transduction, Research Article, 7TM, 7 transmembrane domain, Receptors, CCR1, PBS, phosphate-buffered saline, Rodentia, ICL, intracellular loop, ECL, extracellular loop, Structure-Activity Relationship, 03 medical and health sciences, sulfotyrosine, receptor internalization, Calcium flux, Animals, eosinophil, BRET, bioluminescence resonance energy transfer, constitutive activity, Molecular Biology, GPCR, G protein-coupled receptor, G protein-coupled receptor, calcium flux, 030102 biochemistry & molecular biology, Cell Membrane, Chemotaxis, Cell Biology, Eosinophils, Mice, Inbred C57BL, 030104 developmental biology, biology.protein, Ccr1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d8eb04029dd1ca8a1ca05532d4c0caTest
https://doi.org/10.1016/j.jbc.2021.100373Test

4

A monoclonal antibody raised against a thermo-stabilised β

المؤلفون: Mark, Soave, Gabriella, Cseke, Catherine J, Hutchings, Alastair J H, Brown, Jeanette, Woolard, Stephen J, Hill

المصدر: Biochemical Pharmacology

مصطلحات موضوعية: Monoclonal antibody, Turkey, Propranolol (Pubchem CID: 4946), IBMX (Pubchem CID: 3758), ICI 118551 (Pubchem CID: 5484725), Isoprenaline (Pubchem CID: 5807), CHO Cells, CGP 20712A (Pubchem CID: 2685), ECL, extracellular loop, CHO, Chinese hamster ovary, Extracellular loop 2, Protein Structure, Secondary, Article, Propanolamines, HEK, human embryonic kidney, Cricetulus, GPCR, Allosteric Regulation, Cricetinae, Allosterism, SPAP, secreted placental alkaline phosphatase, Animals, Humans, Amino Acid Sequence, mAb, monoclonal antibody, Alprenolol (Pubchem CID: 2119), ComputingMethodologies_COMPUTERGRAPHICS, Protein Stability, Antibodies, Monoclonal, ATCM, allosteric ternary complex model, Adrenergic beta-Agonists, Furimazine (Pubchem CID: 219083), Hoechst 33342 (Pubchem CID: 1464), Cimaterol (Pubchem CID: 2755), CGP 12177 (Pubchem CID: 2687), HEK293 Cells, CRE, cAMP response element, Receptors, Adrenergic, beta-1, Protein Binding, StaR, stabilised receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::63b12cac034dba90fb7f5e28b08c1ed2Test
https://pubmed.ncbi.nlm.nih.gov/29102678Test

5

Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

المؤلفون: Alex C. Conner, David R. Poyner, James Barwell

المصدر: Biochimica et Biophysica Acta

مصطلحات موضوعية: Models, Molecular, Extracellular loop, Protein Structure, Secondary, CGRP, calcitonin gene-related peptide, Receptor Activity-Modifying Protein 1, VPAC, vasoactive intestinal peptide receptor, CLR, calcitonin receptor-like receptor, TM, transmembrane domain, Chlorocebus aethiops, Cyclic AMP, 5-HT5A receptor, CGRP, PTH, parathyroid hormone, Calcitonin receptor, Calcitonin Receptor-Like Protein, CT, calcitonin, AM, adrenomedullin, Cell biology, Biochemistry, COS Cells, Protein Binding, Calcitonin Gene-Related Peptide, Molecular Sequence Data, ICL, intracellular loop, ECL, extracellular loop, Biology, Models, Biological, Article, Enzyme-linked receptor, Animals, Humans, Receptor activation, Protein Interaction Domains and Motifs, RMSD, root mean squared deviation, G protein-coupled receptor, Amino Acid Sequence, Molecular Biology, GPCR, G protein-coupled receptor, Juxtamembrane domain, Receptor activity-modifying protein, Cell Membrane, RAMP, receptor activity-modifying protein, Cell Biology, CALCRL, ECD, extracellular domain, Amino Acid Substitution, RAMP1, Mutagenesis, Site-Directed, Cattle, Mutant Proteins, HA, hemagglutinin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a09ecd371d40b599baf230d5460671Test
https://doi.org/10.1016/j.bbamcr.2011.06.005Test

6

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists

المؤلفون: Annika Kreuchwig, Gerd Krause, Ann-Karin Haas, Ralf Schülein, Inna Hoyer

المصدر: Biochemical Society Transactions
Biochemical Society transactions, 41(1): 213-217

مصطلحات موضوعية: Models, Molecular, wt, wild-type, Allosteric regulation, ICL, intracellular loop, ECL, extracellular loop, Biochemistry, GPHR, glycoprotein hormone receptor, S5, Thyrotropin receptor, compound 52, G-coupled-protein receptor, constitutively activating mutation, thyrotropin receptor, small molecular ligands, GO, Graves’ ophthalmopathy, LHCGR, luteinizing hormone/choriogonadotropin receptor, c52, compound 52, Binding site, CAM, constitutively activating mutation, Receptor, GPCR, G-protein-coupled receptor, chemistry.chemical_classification, Binding Sites, TSHR, thyrotropin receptor, Mutagenesis, Receptors, Thyrotropin, GD, Graves’ disease, Amino acid, Transmembrane domain, chemistry, SML, small-molecule ligand, TMH, transmembrane helix, Pharmacophore, Biochemical Society Focused Meetings, Allosteric Site, TSH, thyroid-stimulating hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fccb05650453d78e29b0c68fcb1c73Test
https://pubmed.ncbi.nlm.nih.gov/23356285Test

7

Interactions of the Melanocortin-4 Receptor with the Peptide Agonist NDP-MSH

المؤلفون: Gemma K. Kinsella, Alan Cox, Dan Donnelly, John B. C. Findlay, Kathryn L. Chapman

المصدر: Journal of Molecular Biology

مصطلحات موضوعية: WT, wild type, Protein Conformation, PDF, probability density function, MTII, melanotan II, Crystallography, X-Ray, Ligands, CuP, copper 1,10-phenanthroline, Conserved sequence, 0302 clinical medicine, Protein structure, Structural Biology, Catalytic Domain, melanocortin-4 receptor (MC4R), Receptor, 0303 health sciences, CRE, cyclic AMP response element, biology, Chemistry, MC1R, melanocortin-1 receptor, Ligand (biochemistry), Transmembrane protein, G-protein-coupled receptor (GPCR), Melanocortin 4 receptor, d-Nal, β-(2-naphthyl)-d-alanine, Biochemistry, Rhodopsin, Receptor, Melanocortin, Type 4, MCR, melanocortin receptor, Static Electricity, ECL, extracellular loop, Article, 03 medical and health sciences, PDB, Protein Data Bank, MSH, melanocyte-stimulating hormone, Humans, hMC4R, human MC4R, MC4R, melanocortin-4 receptor, Molecular Biology, GPCR, G-protein-coupled receptor, 030304 developmental biology, G protein-coupled receptor, NDP-MSH, [Nle4,d-Phe7]melanocyte-stimulating hormone, comparative model, [Nle4,d-Phe7]melanocyte-stimulating hormone (NDP-MSH), alpha-MSH, Mutation, Biophysics, biology.protein, cysteine cross-linking, Peptides, 030217 neurology & neurosurgery, TM, transmembrane

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78009df2a71543d45145d0258804c787Test

8

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

مصطلحات موضوعية: T4L, T4-lysozyme, BRIL, apocytochrome b562RIL, HGMP, hierarchical GPCR modelling protocol, TM, trans-membrane helix, SDM, site-directed mutagenesis, ECL, extracellular loop, 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively, PDB, Protein Data Bank, CRF1, corticotropin releasing factor receptor 1, β2AR, β2-adrenergic receptor, GPCRs, G-protein coupled receptors, GLAS, GPCR-likeness assessment score, α1B Adrenergic receptor, H1, histamine receptor 1, 7TM, seven-transmembrane domain, 3D, three-dimensional, δ-OR, delta-opioid receptor, GLP-1, Glucagon-like peptide-1 receptor, hM3R, human muscarinic M3 receptor, Dopamine D2 receptor, CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors, 3. Good health, ProS, pairwise protein similarity method, MD, molecular dynamic simulations, CCK2R, cholecystokinin receptor-2, XFELs, x-ray free electron lasers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2173e66f5c24b1f0755c14aa47a50559Test

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