دورية أكاديمية
Lymphoproliferative diseases in primary Sjogren's syndrome
| العنوان: | Lymphoproliferative diseases in primary Sjogren's syndrome |
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| المؤلفون: | V. i. Vasiljev, N. A. Probatova, N. N. Tupitsyn, E. Y. Varlamova, O. A. Logvinenko, A. M. Kovrigina, E. M. Sholohova, M. V. Simonova, T. N. Safonova, V. R. Gorodetsky, N. V. Kokosadze, A. M. Pavlovskaya, T. N. Kondratjeva, Z. G. Kadagidze, E. V. Gayduk |
| المصدر: | Онкогематология, Vol 0, Iss 3, Pp 16-26 (2022) |
| بيانات النشر: | ABV-press, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | primary sjogren's syndrome, non-hodgkin's lymphoma, lymphoproliferative diseases, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | During long term follow up (median 10 years) of 412 patients with primary Sjogren's syndrome (pSS) 46; (11,2%) women developed non-Hodgkin's lymphoma (NHL). Median pSS duration before development of NHL was 17 years. 43 (93,3%) patients had B-cell and 3 (6,7%) - T-cell NHL. All types of NHL were present except precursor cell lymphomas. Diffuse large B-cell lymphoma (LBCL) (39%) and MALT lymphomas (21%) prevailed. Nodal NHL with extranodal involvement (52,2%) were the most frequent. Nodal (21,8%) and extranodal (26%) lymphomas were less frequent. The most frequent target organs in lymphoproliferative disease (LPD) were lymph nodes (74%), salivary glands (45,5%), lungs (26%), bone marrow (19,5%), liver (17,5%), spleen (13%), lachrymal glands (6,5%). Waldeyer's throat ring (4%), oral cavity mucous membrane, ovary and brain (2%) were involved rarely. Immunoglobulin-secreting variant of lymphoma was revealed in 53,7% of cases. LPD developed predominantly in patients with systemic features and late stage of pSS. Significant increase of parotis, mixed monoclonal cryoglobulinemia, generalized lymphadenopathy, presence of more than 5 focuses of lymphoid infiltration in small salivary glands biopsies and thrombocytopenia were predictors of NHL development in pSS (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1818-8346 2413-4023 |
| العلاقة: | https://oncohematology.abvpress.ru/ongm/article/view/615Test; https://doaj.org/toc/1818-8346Test; https://doaj.org/toc/2413-4023Test |
| DOI: | 10.17650/1818-8346-2007-0-3-16-26 |
| الوصول الحر: | https://doaj.org/article/8a947f2af17e42a58b1c3ea1e6aded5bTest |
| رقم الانضمام: | edsdoj.8a947f2af17e42a58b1c3ea1e6aded5b |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 18188346 24134023 |
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| DOI: | 10.17650/1818-8346-2007-0-3-16-26 |