المؤلفون: Kathryn E Mangold, Wei Wang, Eric K Johnson, Druv Bhagavan, Jonathan D Moreno, Jeanne M Nerbonne, Jonathan R Silva

المصدر: PLoS Computational Biology, Vol 17, Iss 8, p e1008932 (2021)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1553-734XTest; https://doaj.org/toc/1553-7358Test

الوصول الحر: https://doaj.org/article/3aacf089bcfd4490b3426bc8206f6128Test

المؤلفون: Kathryn E. Mangold (1969360), Wei Wang (17594), Eric K. Johnson (11278882), Druv Bhagavan (11278885), Jonathan D. Moreno (11278888), Jeanne M. Nerbonne (8117018), Jonathan R. Silva (4430242)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, channel dynamics, Successful models, models Markov models, model topology, channel function, Markov model topologies, voltage-gated ion channel currents, ion channel, mouse atrial sodium currents, Markov models, model performance, channel models, ion channel dynamics, potassium currents, tissue simulations, Past studies, channel model creation pipeline

العلاقة: https://figshare.com/articles/journal_contribution/Supplementary_Equations_Methods_and_Example_Model_Rate_Constants/15175114Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1008932.s001Test

المؤلفون: Kathryn E. Mangold, Jonathan D. Moreno, Woenho Chung, Jonathan R. Silva, Wandi Zhu

المصدر: JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 736-751 (2019)

مصطلحات موضوعية: 0301 basic medicine, Drug, lcsh:Diseases of the circulatory (Cardiovascular) system, Computer science, media_common.quotation_subject, In silico, Computational biology, 030204 cardiovascular system & hematology, Nav1.5, Ventricular tachycardia, EAD, early afterdepolarization, IC50, half-maximal inhibitory voltage, 03 medical and health sciences, 0302 clinical medicine, computational biology, SSA, steady-state availability, Mexiletine, APD, action potential duration, VSD, voltage-sensing domain, medicine, UDB, use-dependent block, media_common, TRANSLATIONAL MODEL, biology, Drug discovery, translational studies, LQT3, long QT syndrome type 3, BCL2000, basic cycle length of 2,000 ms, DIII-VSD, domain III voltage-sensing domain, ion channels, medicine.disease, 3. Good health, RFI, recovery from inactivation, 030104 developmental biology, lcsh:RC666-701, biology.protein, V1/2, half-maximal voltage, pharmacology, Cardiology and Cardiovascular Medicine, arrhythmias, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c1aba62105f94a71b2216f4cd77a80Test
http://europepmc.org/articles/PMC6834944Test

المؤلفون: Wei Wang, Kathryn E. Mangold, Druv Bhagavan, Jonathan R. Silva, Jeanne M. Nerbonne, Eric K. Johnson, Jonathan D. Moreno

المصدر: PLoS Computational Biology, Vol 17, Iss 8, p e1008932 (2021)
PLoS Computational Biology

مصطلحات موضوعية: Patch-Clamp Techniques, Databases, Factual, Physiology, Computer science, Pipeline (computing), Connection (vector bundle), Action Potentials, Voltage-Gated Sodium Channels, Biochemistry, Ion Channels, Stiffness, Mice, Animal Cells, Medicine and Health Sciences, Biology (General), Topology (chemistry), Ecology, Physics, Simulation and Modeling, Models, Cardiovascular, Markov Chains, Electrophysiology, Computational Theory and Mathematics, Potassium Channels, Voltage-Gated, Modeling and Simulation, Physical Sciences, Simulated annealing, A priori and a posteriori, Cellular Types, Anatomy, Biological system, Research Article, Communication channel, Optimization, Markov Models, Permutation, QH301-705.5, Heart Ventricles, Materials Science, Material Properties, Biophysics, Muscle Tissue, Neurophysiology, Research and Analysis Methods, Markov model, Network topology, Topology, Membrane Potential, Biophysical Phenomena, Set (abstract data type), Cellular and Molecular Neuroscience, Genetics, Mechanical Properties, Animals, Humans, Computer Simulation, Heart Atria, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Muscle Cells, Discrete Mathematics, Myocardium, Biology and Life Sciences, Proteins, Computational Biology, Cell Biology, Function (mathematics), Probability Theory, Kinetics, Biological Tissue, HEK293 Cells, Combinatorics, Transient (oscillation), State (computer science), Mathematics, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e37b4d15397c0e087a505b10f10b27Test
https://doi.org/10.1101/2021.04.06.438566Test

المؤلفون: Kathryn E. Mangold, Jonathan R. Silva

المصدر: Modeling and Simulating Cardiac Electrical Activity ISBN: 9780750320641
Modeling and Simulating Cardiac Electrical Activity

مصطلحات موضوعية: Materials science, Chemical physics, Ion channel

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bf44d454700fef684be424abf10ae1b4Test
https://doi.org/10.1088/978-0-7503-2064-1ch2Test

المؤلفون: Kathryn E. Mangold (1969360), Wei Wang (17594), Eric K. Johnson (11278882), Druv Bhagavan (11278885), Jonathan D. Moreno (11278888), Jeanne M. Nerbonne (8117018), Jonathan R. Silva (4430242)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, channel dynamics, Successful models, models Markov models, model topology, channel function, Markov model topologies, voltage-gated ion channel currents, ion channel, mouse atrial sodium currents, Markov models, model performance, channel models, ion channel dynamics, potassium currents, tissue simulations, Past studies, channel model creation pipeline

العلاقة: https://figshare.com/articles/figure/Stiffness_penalties_for_I_sub_to_f_sub_optimized_models_across_all_optimization_starts_/15175123Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1008932.s004Test

المؤلفون: Kathryn E. Mangold (1969360), Wei Wang (17594), Eric K. Johnson (11278882), Druv Bhagavan (11278885), Jonathan D. Moreno (11278888), Jeanne M. Nerbonne (8117018), Jonathan R. Silva (4430242)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, channel dynamics, Successful models, models Markov models, model topology, channel function, Markov model topologies, voltage-gated ion channel currents, ion channel, mouse atrial sodium currents, Markov models, model performance, channel models, ion channel dynamics, potassium currents, tissue simulations, Past studies, channel model creation pipeline

العلاقة: https://figshare.com/articles/figure/State_probabilities_throughout_recovery_from_inactivation_protocol_for_I_sub_to_f_sub_illustrates_differences_between_acceptable_and_unacceptable_models_/15175129Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1008932.s006Test

المؤلفون: Kathryn E. Mangold (1969360), Wei Wang (17594), Eric K. Johnson (11278882), Druv Bhagavan (11278885), Jonathan D. Moreno (11278888), Jeanne M. Nerbonne (8117018), Jonathan R. Silva (4430242)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, channel dynamics, Successful models, models Markov models, model topology, channel function, Markov model topologies, voltage-gated ion channel currents, ion channel, mouse atrial sodium currents, Markov models, model performance, channel models, ion channel dynamics, potassium currents, tissue simulations, Past studies, channel model creation pipeline

العلاقة: https://figshare.com/articles/figure/Example_I_sub_to_f_sub_model_with_6_free_rate_constants/15175126Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1008932.s005Test

المؤلفون: Kathryn E. Mangold (1969360), Wei Wang (17594), Eric K. Johnson (11278882), Druv Bhagavan (11278885), Jonathan D. Moreno (11278888), Jeanne M. Nerbonne (8117018), Jonathan R. Silva (4430242)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, channel dynamics, Successful models, models Markov models, model topology, channel function, Markov model topologies, voltage-gated ion channel currents, ion channel, mouse atrial sodium currents, Markov models, model performance, channel models, ion channel dynamics, potassium currents, tissue simulations, Past studies, channel model creation pipeline

العلاقة: https://figshare.com/articles/figure/Example_model_for_I_sub_Na_sub_with_9_free_rate_constants_/15175138Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1008932.s009Test

المؤلفون: Kathryn E. Mangold (1969360), Wei Wang (17594), Eric K. Johnson (11278882), Druv Bhagavan (11278885), Jonathan D. Moreno (11278888), Jeanne M. Nerbonne (8117018), Jonathan R. Silva (4430242)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, channel dynamics, Successful models, models Markov models, model topology, channel function, Markov model topologies, voltage-gated ion channel currents, ion channel, mouse atrial sodium currents, Markov models, model performance, channel models, ion channel dynamics, potassium currents, tissue simulations, Past studies, channel model creation pipeline

العلاقة: https://figshare.com/articles/figure/Illustration_of_progress_and_generalization_loss_measures_stopping_an_optimization_early_as_described_in_46_/15175120Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1008932.s003Test