Antiproliferative and antimicrobial activities of alkylbenzoquinone derivatives fromArdisia kivuensis
| العنوان: | Antiproliferative and antimicrobial activities of alkylbenzoquinone derivatives fromArdisia kivuensis |
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| المؤلفون: | Inshad Ali Khan, Saxena K. Ajit, Dzoyem J. Paul, Ram A. Vishwakarma, Tane Pierre, Santosh Kumar Guru, Ndontsa B. Laure |
| المصدر: | Pharmaceutical Biology. 52:392-397 |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Stereochemistry, Pharmaceutical Science, Apoptosis, Microbial Sensitivity Tests, Gram-Positive Bacteria, Ardisia, Inhibitory Concentration 50, chemistry.chemical_compound, Minimum inhibitory concentration, Anti-Infective Agents, Cell Line, Tumor, Neoplasms, Drug Discovery, Benzoquinones, Humans, Cytotoxicity, Medicinal plants, Pharmacology, biology, Traditional medicine, Plant Extracts, Fungi, General Medicine, Myrsinaceae, Flow Cytometry, biology.organism_classification, Antimicrobial, Antineoplastic Agents, Phytogenic, Complementary and alternative medicine, chemistry, Molecular Medicine, Growth inhibition, Bacteria |
| الوصف: | Medicinal plants are continuously screened for their pharmacological properties. Despite the diversity and the numerous phytochemicals found in Ardisia (Myrsinaceae) species, its full biological potential has not been fully explored.Four naturally occurring alkylbenzoquinone derivatives, namely ardisiaquinone N (1), ardisiaquinone J (2), ardisiaquinone K (3) and a mixture of ardisiaquinone P (4) and K (3) from Ardisia kivuensis Taton (Myrsinaceae) were investigated in vitro for their cytotoxicity and antimicrobial activity.Minimal inhibitory concentration (MIC) was determined using the broth micro-dilution assay. Tumor cells growth inhibition was performed by sulphorhodamine B (SRB) assay while sub-diploid DNA fraction was measured by flow cytometry.Compounds 1, 2 and 3 showed significant antimicrobial activity against two Gram-positive bacteria and one fungus (with MICs varying between 3.12 and 6.25 µg/ml). The four compounds exhibited remarkable antiproliferative activity against the leukemia cell line TPH-1 with IC₅₀ inhibition values between 2 and 2.1 µg/ml. Cytotoxic activity was found to be related to apoptosis induction.These findings suggest that natural compounds herein studied are interesting potential candidates for the development of new therapeutic agents, especially against leukemia and Gram-positive bacterial infections. |
| تدمد: | 1744-5116 1388-0209 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da865fdc2a34f98c59123afd9aa87778Test https://doi.org/10.3109/13880209.2013.837076Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da865fdc2a34f98c59123afd9aa87778 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17445116 13880209 |
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