التفاصيل البيبلوغرافية
العنوان:
A Quantitative Proteome Map of the Human Body
المؤلفون:
Lihua Jiang , Meng Wang , Shin Lin , Ruiqi Jian , Xiao Li , Joanne Chan , Guanlan Dong , Huaying Fang , Aaron E. Robinson , Michael P. Snyder , François Aguet , Shankara Anand , Kristin G. Ardlie , Stacey Gabriel , Gad Getz , Aaron Graubert , Kane Hadley , Robert E. Handsaker , Katherine H. Huang , Seva Kashin , Daniel G. MacArthur , Samuel R. Meier , Jared L. Nedzel , Duyen Y. Nguyen , Ayellet V. Segrè , Ellen Todres , Brunilda Balliu , Alvaro N. Barbeira , Alexis Battle , Rodrigo Bonazzola , Andrew Brown , Christopher D. Brown , Stephane E. Castel , Don Conrad , Daniel J. Cotter , Nancy Cox , Sayantan Das , Olivia M. de Goede , Emmanouil T. Dermitzakis , Barbara E. Engelhardt , Eleazar Eskin , Tiffany Y. Eulalio , Nicole M. Ferraro , Elise Flynn , Laure Fresard , Eric R. Gamazon , Diego Garrido-Martín , Nicole R. Gay , Roderic Guigó , Andrew R. Hamel , Yuan He , Paul J. Hoffman , Farhad Hormozdiari , Lei Hou , Hae Kyung Im , Brian Jo , Silva Kasela , Manolis Kellis , Sarah Kim-Hellmuth , Alan Kwong , Tuuli Lappalainen , Xin Li , Yanyu Liang , Serghei Mangul , Pejman Mohammadi , Stephen B. Montgomery , Manuel Muñoz-Aguirre , Daniel C. Nachun , Andrew B. Nobel , Meritxell Oliva , YoSon Park , Yongjin Park , Princy Parsana , Ferran Reverter , John M. Rouhana , Chiara Sabatti , Ashis Saha , Andrew D. Skol , Matthew Stephens , Barbara E. Stranger , Benjamin J. Strober , Nicole A. Teran , Ana Viñuela , Gao Wang , Xiaoquan Wen , Fred Wright , Valentin Wucher , Yuxin Zou , Pedro G. Ferreira , Gen Li , Marta Melé , Esti Yeger-Lotem , Mary E. Barcus , Debra Bradbury , Tanya Krubit , Jeffrey A. McLean , Liqun Qi , Karna Robinson , Nancy V. Roche , Anna M. Smith , Leslie Sobin , David E. Tabor , Anita Undale , Jason Bridge , Lori E. Brigham , Barbara A. Foster , Bryan M. Gillard , Richard Hasz , Marcus Hunter , Christopher Johns , Mark Johnson , Ellen Karasik , Gene Kopen , William F. Leinweber , Alisa McDonald , Michael T. Moser , Kevin Myer , Kimberley D. Ramsey , Brian Roe , Saboor Shad , Jeffrey A. Thomas , Gary Walters , Michael Washington , Joseph Wheeler , Scott D. Jewell , Daniel C. Rohrer , Dana R. Valley , David A. Davis , Deborah C. Mash , Philip A. Branton , Laura K. Barker , Heather M. Gardiner , Maghboeba Mosavel , Laura A. Siminoff , Paul Flicek , Maximilian Haeussler , Thomas Juettemann , W. James Kent , Christopher M. Lee , Conner C. Powell , Kate R. Rosenbloom , Magali Ruffier , Dan Sheppard , Kieron Taylor , Stephen J. Trevanion , Daniel R. Zerbino , Nathan S. Abell , Joshua Akey , Lin Chen , Kathryn Demanelis , Jennifer A. Doherty , Andrew P. Feinberg , Kasper D. Hansen , Peter F. Hickey , Farzana Jasmine , Rajinder Kaul , Muhammad G. Kibriya , Jin Billy Li , Qin Li , Sandra E. Linder , Brandon L. Pierce , Lindsay F. Rizzardi , Kevin S. Smith , John Stamatoyannopoulos , Hua Tang , Latarsha J. Carithers , Ping Guan , Susan E. Koester , A. Roger Little , Helen M. Moore , Concepcion R. Nierras , Abhi K. Rao , Jimmie B. Vaught , Simona Volpi
المصدر:
Cell
بيانات النشر:
Elsevier BV, 2020.
سنة النشر:
2020
مصطلحات موضوعية:
Proteomics , Cell signaling , Proteome , Quantitative proteomics , Gene Expression , Disease , Computational biology , Biology , ENCODE , Article , General Biochemistry, Genetics and Molecular Biology , Transcriptome , 03 medical and health sciences , 0302 clinical medicine , Humans , Secretion , RNA, Messenger , Gene , 030304 developmental biology , 0303 health sciences , Gene Expression Profiling , RNA , Metabolism , Phenotype , Secretory protein , 030217 neurology & neurosurgery
الوصف:
Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins (5,499) were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly tissue specific proteins. Discordance in the sites of RNA expression and protein detection also revealed potential sites of synthesis and action of protein signaling molecules. Overall, these results provide an extraordinary resource, and demonstrate that understanding protein levels can provide insights into metabolism, regulation, secretome, and human diseases.SummaryQuantitative proteome study of 32 human tissues and integrated analysis with transcriptome data revealed that understanding protein levels could provide in-depth knowledge to post transcriptional or translational regulations, human metabolism, secretome, and diseases.
وصف الملف:
application/pdf
تدمد:
0092-8674
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fecfd381ad58880ff2fe2b28799a97Test https://doi.org/10.1016/j.cell.2020.08.036Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....62fecfd381ad58880ff2fe2b28799a97
قاعدة البيانات:
OpenAIRE
