دورية أكاديمية

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

التفاصيل البيبلوغرافية
العنوان: Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
المؤلفون: Tyrer, Jonathan, Shen, Howard C, Lawrenson, Kate, Lee, Janet M, Spindler, Tassja J, Lin, Yvonne G, Pejovic, Tanja, Bean, Yukie, Li, Qiyuan, Coetzee, Simon, Hazelett, Dennis, Isaccs, Claudine, Hein, Alexander, Ekici, Arif B, Beckmann, Matthias W, Fasching, Peter A, Lambrechts, Diether, Van Nieuwenhuysen, Els, Vergote, Ignace, Lambrechts, Sandrina, Doherty, Jennifer A, Wicklund, Kristine G, Rossing, Mary Anne, Rudolph, Anja, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Lele, Shashi, Wilkens, Lynne R, Goodman, Marc T, Thompson, Pamela J, Shvetsov, Yurii B, Runnebaum, Ingo B, Dürst, Matthias, Hillemanns, Peter, Dörk, Thilo, Antonenkova, Natalia, Bogdanova, Natalia, Leminen, Arto, Pelttari, Liisa M, Butzow, Ralf, Modugno, Francesmary, Kelley, Joseph L, Edwards, Robert P, Ness, Roberta B, du Bois, Andreas, Heitz, Florian, Schwaab, Ira, Harter, Philipp, Matsuo, Keitaro, Hosono, Satoyo, Jensen, Allan, Kjaer, Susanne Kruger, Hogdall, Estrid, Hasmad, Hanis Nazihah, Azmi, Mat Adenan Noor, Woo, Yin-Ling, Fridley, Brooke L, Goode, Ellen L, Vierkant, Robert A, Bruinsma, Fiona, Liang, Dong, Hildebrandt, Michelle A T, Wu, Xifeng, Levine, Douglas A, Bisogna, Maria, Berchuck, Andrew, Iversen, Edwin S, Schildkraut, Joellen M, Concannon, Patrick, Weber, Rachel Palmieri, Cramer, Daniel W, Terry, Kathryn L, Poole, Elizabeth M, Tworoger, Shelley S, Bandera, Elisa V, Orlow, Irene, Olson, Sara H, Krakstad, Camilla, Salvesen, Helga B, Tangen, Ingvild L, Bjorge, Line, van Altena, Anne M, Aben, Katja K H, Kiemeney, Lambertus A, Massuger, Leon F A G, Kellar, Melissa, Brooks-Wilson, Angela, Kelemen, Linda E, Cook, Linda S, Le, Nhu D, Yang, Hannah, Lissowska, Jolanta, Brinton, Louise A, Wentzensen, Nicolas, Hogdall, Claus, Lundvall, Lene, Nedergaard, Lotte, Baker, Helen, Song, Honglin, McNeish, Ian, Paul, James, Carty, Karen, Siddiqui, Nadeem, Glasspool, Rosalind, Rothstein, Joseph H, McGuire, Valerie, Sieh, Weiva, Ji, Bu-Tian, Zheng, Wei, Shu, Xiao-Ou, Gao, Yu-Tang, Rosen, Barry, Risch, Harvey A, McLaughlin, John R, Monteiro, Alvaro N, Chen, Ann, Lin, Hui-Yi, Permuth-Wey, Jenny, Sellers, Thomas A, Tsai, Ya-Yu, Chen, Zhihua, Ziogas, Argyrios, Anton-Culver, Hoda, Gentry-Maharaj, Aleksandra, Menon, Usha, Lee, Alice W, Wu, Anna H, Pearce, Celeste L, Coetzee, Gerry, Pike, Malcolm C, Dansonka-Mieszkowska, Agnieszka, Timorek, Agnieszka, Rzepecka, Iwona K, Kupryjanczyk, Jolanta, Freedman, Matt, Noushmehr, Houtan, Gayther, Simon, Pharoah, Paul P, Parsons, Peter G, Hayward, Nicholas K, Purdie, David M, Whiteman, David C, Bowtell, D, Chenevix-Trench, G, Green, Adele C, Webb, P, deFazio, A, Gertig, D, Goldgar, David E, John, Esther M, Terry, Mary Beth, Whittemore, Alice S, Buys, Saundra S, Chung, Wendy K, Daly, Mary B, Southey, Melissa, Miron, Alex, Janavicius, Ramunas, Rudaitis, Vilius, Eglitis, Janis, Tihomirova, Laima, Nikitina-Zake, Liene, Tung, Nadine, Dorfling, Cecilia M, van Rensburg, Elizabeth J, Steele, Linda, Neuhausen, Susan L, Ding, Yuan Chun, Gerdes, Anne-Marie, Ejlertsen, Bent, Nielsen, Finn C, Jønson, Lars, Andersen, Mette K, Hansen, Thomas V O, Lee, Andrew, Antoniou, Antonis C, Barrowdale, Daniel, Dennis, Joe, Kuchenbaecker, Karoline B, McGuffog, Lesley, Healey, Sue, Easton, Douglas F, Lee, Adam, Wang, Chen, Cunningham, Julie, Hart, Steven, Slager, Susan, Lasa, Adriana, Osorio, Ana, Benitez, Javier, Godino, Javier, Tejada, Maria-Isabel, Garcia, Maria Jose, Duran, Mercedes, Hall, Per, Dicks, Ed, Fontaine, Annette, Komenaka, Ian, Weitzel, Jeffrey N, Herzog, Josef, Ganschow, Pamela, Peterlongo, Paolo, Pilato, Brunella, Lambo, Rosanna, Tommasi, Stefania, Sardella, Domenico, Capra, Fabio, Ficarazzi, Filomena, Mariette, Frederique, Tizzoni, Laura, Bernard, Loris, Mariani, Paolo, Volorio, Sara, Fortuzzi, Stefano, Dall'Olio, Valentina, Pensotti, Valeria, Viel, Alessandra, Dolcetti, Riccardo, Bonanni, Bernardo, Feroce, Irene, Barile, Monica, Peissel, Bernard, Zaffaroni, Daniela, Cattaneo, Elisa, Roversi, Gaia, Melloni, Giulia, Scuvera, Giulietta, Radice, Paolo, Manoukian, Siranoush, Martayan, Aline, Savarese, Antonella, Varesco, Liliana, Gismondi, Viviana, Putignano, Anna Laura, Papi, Laura, Genuardi, Maurizio, Tibiletti, Maria Grazia, Ottini, Laura, Allavena, Anna, Pasini, Barbara, Vignolo-Lutati, Francesca, Vratimos, Athanassios, Fostira, Florentia, Fountzilas, George, Konstantopoulou, Irene, Apostolou, Paraskevi, Garber, Judy, Torres, Diana, Rashid, Muhammad Usman, Hamann, Ute, Donaldson, Alan, Murray, Alex, Dunning, Alison M, Chu, Carol, Brewer, Carole, Houghton, Catherine, Jacobs, Chris, Oliver, Clare, Evans, D Gareth, Frost, Debra, Eccles, Diana, Fineberg, Elena, Ellis, Steve, Platte, Radka, Perkins, Jo, Miedzybrodzka, Zosia, Gregory, Helen, Morrison, Patrick, Jeffers, Lisa, Ong, Kai-ren, Hoffman, Jonathan, James, Margaret, Paterson, Joan, Tischkowitz, Marc, Downing, Sarah, Taylor, Amy, Murray, Alexandra, Rogers, Mark T, McCann, Emma, Kennedy, M John, Barton, David, Porteous, Mary, Drummond, Sarah, Kivuva, Emma, Searle, Anne, Goodman, Selina, Hill, Kathryn, Davidson, Rosemarie, Murday, Victoria, Bradshaw, Nicola, Snadden, Lesley, Longmuir, Mark, Watt, Catherine, Gibson, Sarah, Haque, Eshika, Tobias, Ed, Duncan, Alexis, Izatt, Louise, Langman, Caroline, Dorkins, Huw, Barwell, Julian, Adlard, Julian, Serra-Feliu, Gemma, Ellis, Ian, Foo, Claire, Lalloo, Fiona, Taylor, Jane, Side, Lucy, Male, Alison, Berlin, Cheryl, Eason, Jacqueline, Collier, Rebecca, Henderson, Alex, Claber, Oonagh, Jobson, Irene, Walker, Lisa, McLeod, Diane, Halliday, Dorothy, Durell, Sarah, Stayner, Barbara, Eeles, Ros, Rahman, Nazneen, Bancroft, Elizabeth, Page, Elizabeth, Ardern-Jones, Audrey, Kohut, Kelly, Wiggins, Jennifer, Pope, Jenny, Saya, Sibel, Taylor, Natalie, Kemp, Zoe, Cook, Jackie, Quarrell, Oliver, Bardsley, Cathryn, Hodgson, Shirley, Goff, Sheila, Brice, Glen, Winchester, Lizzie, Eddy, Charlotte, Tripathi, Vishakha, Attard, Virginia, Lucassen, Anneke, Crawford, Gillian, McBride, Donna, Smalley, Sarah, Douglas, Fiona, ichert, Gabriella, Side, Lucy E, Cook, Margaret, Porteous, Mary E, Harrington, Patricia, Morrison, Patrick J, Peock, Susan, Cole, Trevor, Godwin, Andrew K, Bove, Betsy, Weaver, JoEllen, Sharma, Priyanka, Lee, Annette, Shapira, Iuliana, Vega, Ana, Becker, Alexandra, Meindl, Alfons, Gehrig, Andrea, Baumgärtner, Anne, Wappenschmidt, Barbara, Weber, Bernhard H F, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Schäfer, Dieter, Steinemann, Doris, Gadzicki, Dorothea, Hahnen, Erick, Plendl, Hansjoerg, Deissler, Helmut, Ruehl, Ina, Kast, Karin, Rhiem, Kerstin, Ditsch, Nina, Arnold, Norbert, Varon-Mateeva, Raymonda, Schmutzler, Rita Katharina, Preisler-Adams, Sabine, Heidemann, Simone, Engert, Stefanie, Heinritz, Wolfram, Hardouin, Agnès, Calender, Alain, de Pauw, Antoine, Bressac-de Paillerets, Brigitte, Buecher, Bruno, Delnatte, Capucine, Tirapo, Carole, Verny-Pierre, Carole, Kientz, Caroline, Nogues, Catherine, Lasset, Christine, Houdayer, Claude, Muller, Danièle, Leroux, Dominique, Stoppa-Lyonnet, Dominique, Rouleau, Etienne, Lesueur, Fabienne, Prieur, Fabienne, Damiola, Francesca, Sinilnikova, Olga, Mazoyer, Sylvie, Barjhoux, Laure, Giraud, Sophie, Léone, Mélanie, Boutry-Kryza, Nadia, Gauthier-Villars, Marion, Golmard, Lisa, Collet, Agnès, Moncoutier, Virginie, Lefol, Cédrick, Belotti, Muriel, Elan, Camille, Fourme, Emmanuelle, Birot, Anne-Marie, Bressac-de-Paillerets, Brigitte, Caron, Olivier, Guillaud-Bataille, Marine, Bignon, Yves-Jean, Uhrhammer, Nancy, Bonadona, Valérie, Handallou, Sandrine, Berthet, Pascaline, Vaur, Dominique, Castera, Laurent, Sobol, Hagay, Bourdon, Violaine, Noguchi, Tetsuro, Remenieras, Audrey, Eisinger, François, Coupier, Isabelle, Pujol, Pascal, Peyrat, Jean-Philippe, Fournier, Joëlle, Révillion, Françoise, Vennin, Philippe, Adenis, Claude, Fricker, Jean-Pierre, Barouk-Simonet, Emmanuelle, Bonnet, Françoise, Bubien, Virginie, Sevenet, Nicolas, Longy, Michel, Toulas, Christine, Guimbaud, Rosine, Gladieff, Laurence, Feillel, Viviane, Dreyfus, Hélène, Rebischung, Christine, Peysselon, Magalie, Coron, Fanny, Faivre, Laurence, Lebrun, Marine, Ferrer, Sandra Fert, Frénay, Marc, Vénat-Bouvet, Laurence, Mortemousque, Isabelle, Coulet, Florence, Colas, Chrystelle, Soubrier, Florent, Warcoin, Mathilde, Sokolowska, Johanna, Bronner, Myriam, Lynch, Henry T, Snyder, Carrie L, Venat-Bouvet, Laurence, Akloul, Linda, Frenay, Marc, Collonge-Rame, Marie-Agnès, Remon, Marie-Alice, Fassy-Colcombet, Marion, Léoné, Mélanie, Caux-Moncoutier, Virginie, Isaacs, Claudine, De Paepe, Anne, Poppe, Bruce, Claes, Kathleen, De Leeneer, Kim, Cohn, David E, O'Malley, David M, Rodriguez, Gustavo C, Basil, Jack B, Hoffman, James S, Fiorica, James V, Hurteau, Jean A, Boggess, John F, Byron, John W, Carter, Jonathan, Kirk, Judy, Wakeley, Katie, Small, Laurie, Andrews, Lesley, DeMars, Leslie R, Van Le, Linda, Piedmonte, Marion, Azodi, Masoud, Friedlander, Michael, DiSilvestro, Paul A, Schwartz, Peter E, Salani, Ritu, Nerenstone, Stacy R, Blank, Stephanie V, Bae-Jump, Victoria L, Romero, Atocha, de la Hoya, Miguel, Segura, Pedro Perez, Caldes, Trinidad, Nevanlinna, Heli, Aittomäki, Kristiina, Khan, Sofia, Muranen, Taru A, Jager, Agnes, van der Hout, Annemarie H, van den Ouweland, Ans M W, Hollestelle, Antoinette, Mensenkamp, Arjen R, van Deurzen, Carolien H M, Kets, Carolien M, van Asperen, Christi J, Aalfs, Cora M, Garcia, Encarna B Gómez, van Leeuwen, Flora E, Hogervorst, Frans B L, van der Baan, Frederieke H, Meijers-Heijboer, Hanne E J, Vasen, Hans F A, Rookus, M A, Hogervorst, F B L, van Leeuwen, F E, Verhoef, S, Schmidt, M K, Russell, N S, de Lange, J L, Wijnands, R, Collée, J M, van den Ouweland, A M W, Hooning, M J, Seynaeve, C, van Deurzen, C H M, Obdeijn, I M, van Asperen, C J, Wijnen, J T, Tollenaar, R A E M, Devilee, P, van Cronenburg, T C T E F, Kets, C M, Mensenkamp, A R, Ausems, M G E M, van der Luijt, R B, van der Pol, C C, Aalfs, C M, van Os, T A M, Gille, J J P, Waisfisz, Q, Meijers-Heijboer, H E J, Gómez-Garcia, E B, Blok, M J, Vasen, H F, Siesling, S, Verloop, J, Overbeek, L I H, Kluijt, Irma, Collee, J Margriet, Knol-Bout, Jacoba P, Oosterwijk, Jan C, Wijnen, Juul T, van Roozendaal, K E P, Schrijver, Lieske H, Hooning, Maartje J, Tilanus-Linthorst, Madeleine A, Ausems, Margreet G E M, Blom, Marie-Jose, van Dooren, Marieke F, Blok, Marinus J, Ligtenberg, Marjolijn J L, Rookus, Matti A, Kriege, Mieke, Hoogerbrugge, Nicoline, Devilee, Peter, Waisfisz, Quinten, van der Luijt, Rob B, Verhoef, Senno, van Os, Theo A M, Kwong, Ava, Ma, Edmund, Chan, T L, Olah, Edith, Papp, Janos, Vaszko, Tibor, Pocza, Timea, Balmana, Judith, Bosch, Nina, Diez, Orland, Teule, Alex, Izquierdo, Angel, Velasco, Angela, Solanes, Ares, Lazaro, Conxi, Darder, Esther, Tornero, Eva, Capella, Gabriel, Blanco, Ignacio, Del Valle, Jesus, Brunet, Joan, Feliubadalo, Lidia, Navarro, Matilde, Pujana, Miquel Angel, Menendez, Mireia, Salinas, Monica, Iglesias, Silvia, Toloczko-Grabarek, Aleksandra, Jakubowska, Anna, Gorski, Bohdan, Cybulski, Cezary, Złowocka-Perłowska, Elżbieta, Sukiennicki, Grzegorz, Gronwald, Jacek, Lubinski, Jan, Menkiszak, Janusz, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, bniak, Tadeusz D, Byrski, Tomasz, Huzarski, Tomasz, Arason, Adalgeir, Agnarsson, Bjarni A, Johannsson, Oskar Th, Barkardottir, Rosa B, Lesperance, Bernard, Maugard, Christine, Chiquette, Jocelyne, Plante, Marie, Dumont, Martine, Laframboise, Rachel, Simard, Jacques, Soucy, Penny, Casella, Cinzia, Alducci, Elisa, D'Andrea, Emma, Montagna, Marco, Tognazzo, Silvia, Agata, Simona, Peixoto, Ana, Teixeira, Manuel R, Holland, Helene, Beesley, Jonathan, Aghmesheh, Morteza, Amor, David, Antill, Yoland, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Bankier, Agnes, Bastick, Patti, Beilby, John, Bennett, Barbara, Bennett, Ian, Berry, Geoffrey, Blackburn, Anneke, Bogwitz, Michael, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burgess, Matthew, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Chauhan, Deepa, Chauhan, Manisha, Christian, Alice, Clarke, Christine, Colley, Alison, Cotton, Dick, Crook, Ashley, Cui, James, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah-Jane, deFazio, Anna, Delatycki, Martin, Dickson, Rebecca, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Edwards, Stacey, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Fellows, Andrew, Fenton, Georgina, Field, Michael, Firgaira, Frank, Flanagan, James, Fleming, Jean, Fong, Peter, Forbes, John, Fox, Stephen, French, Juliet, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Hardie, Kate, Harris, Marion, Hart, Stewart, Hayward, Nick, Heiniger, Louise, Hopper, John, Humphrey, Evelyn, Hunt, Clare, James, Paul, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kidd, Alexa, Kiely, Belinda, Koehler, Jessica, Kollias, James, Kovalenko, Serguei, Lakhani, Sunil, Leaming, Amanda, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Mann, Graham, Marsh, Deborah, McLachlan, Sue Anne, Meiser, Bettina, Meldrum, Cliff, Milne, Roger, Mitchell, Gillian, Newman, Beth, Niedermayr, Eveline, Nightingale, Sophie, O'Connell, Shona, O'Loughlin, Imelda, Osborne, Richard, Pachter, Nick, Patterson, Briony, Peters, Lester, Phillips, Kelly, Price, Melanie, Purser, Lynne, Reeve, Tony, Reeve, Jeanne, Richards, Robert, Rickard, Edwina, Rudzki, Bridget Robinson Barney, Saleh, Mona, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Saunus, Jodi, Sayer, Robyn, Scott, Elizabeth, Scott, Rodney, Scott, Clare, Seshadri, Ram, Sexton, Adrienne, Sharma, Raghwa, Shelling, Andrew, Simpson, Peter, Spurdle, Amanda, Suthers, Graeme, Sykes, Pamela, Tassell, Margaret, Taylor, Donna, Taylor, Jessica, Thierry, Benjamin, Thomas, Susan, Thompson, Ella, Thorne, Heather, Townshend, Sharron, Trainer, Alison, Tran, Lan, Tucker, Kathy, Walker, Logan, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Wu, Kathy, Young, Mary Ann, Chen, Xiaoqing, Lee, Jong Won, Lee, Min Hyuk, Park, Sue K, Kim, Sung-Won, Friebel, Tara, Olswold, Curtis, Stevens, Kristen, Kosel, Matthew, Lindor, Noralane, Pankratz, Vernon S, Wang, Xianshu, Fredericksen, Zachary, Couch, Fergus J, Foulkes, William D, Szabo, Csilla I, Machackova, Eva, Foretova, Lenka, Zikan, Michal, Pohlreich, Petr, Kleibl, Zdenek, Catts, Zohra Ali-Kahn, Dutra-Clarke, Anna, Aghajanian, Carol A, Przybylo, Jennifer, Vijai, Joseph, Sarrel, Kara, Offit, Kenneth, Corines, Marina, Robson, Mark, Gaudet, Mia M, Kauff, Noah, Shah, Sohela, Kirchhoff, Tomas, Berger, Andreas, Fink-Retter, Anneliese, Singer, Christian F, Rappaport, Christine, Kaulich, Daphne Geschwantler, Pfeiler, Georg, Tea, Muy-Kheng, Phelan, Catherine M, Narod, Steven A, Greene, Mark H, Mai, Phuong L, Savage, Sharon A, Loud, Jennifer T, Sherman, Mark E, Lejbkowicz, Flavio, Rennert, Gad, Sokolenko, Anna P, Imyanitov, Evgeny N, Selkirk, Christina, Hulick, Peter, Mulligan, Anna Marie, Glendon, Gord, Ozcelik, Hilmi, Andrulis, Irene L, Tchatchou, Sandrine, Toland, Amanda Ewart, Senter, Leigha, Bojesen, Anders, Skytte, Anne-Bine, Pedersen, Inge Sokilde, Sunde, Lone, Thomassen, Mads, Moeller, Sanne Traasdahl, Væth, Signe, Kruse, Torben A, Jensen, Uffe Birk, Collavoli, Anita, Caligo, Maria A, Tancredi, Mariella, Aretini, Paolo, Teo, Soo-Hwang, Kaufman, Bella, Friedman, Eitan, Zidan, Jamal, Berger, Raanan, Laitman, Yael, Borg, Ake, Öfverholm, Anna, von Wachenfeldt, Anna, Liljegren, Annelie, Lindblom, Annika, Melin, Beatrice, Arver, Brita, Ardnor, Christina Edwinsdotter, Bustinza, Gisela Barbany, Olsson, Håkan, Ehrencrona, Hans, Jernström, Helena, Rantala, Johanna, Henriksson, Karin, Harbst, Katja, Nordling, Margareta, Soller, Maria, Stenmark-Askmalm, Marie, Pigg, Maritta Hellström, Emanuelsson, Monica, Loman, Niklas, Karlsson, Per, Rosenquist, Richard, Liedgren, Sigrun, Kristoffersson, Ulf, Einbeigi, Zakaria, Huo, Dezheng, Sighoko, Dominique, Zhang, Jing, Patrick-Miller, Linda, Verp, Marion, Olopade, Olufunmilayo I, Nielsen, Sarah, Zheng, Yonglan, Seldon, Joyce, Ganz, Patricia A, Nussbaum, Robert L, Chan, Salina B, Moysich, Kirsten B, Odunsi, Kunle, Sucheston, Lara, Pharoah, Paul D P, Gayther, Simon A, Ramus, Susan J, Nathanson, Katherine L, Domchek, Susan M, Rebbeck, Timothy R, Arun, Banu K, Lu, Karen H, Karlan, Beth Y, Walsh, Christine, Lester, Jenny, Orsulic, Sandra, Thames, N E, George, Angela, Fournier, Jean-Philippe Peyrat Joëlle, Oosterwijk, J C, van der Hout, A H, Mourits, M J, de Bock, G H, Robinson, Bridget, Rudzki, Barney, Tyler, Janet, Visvader, Jane
المصدر: Tyrer , J , Shen , H C , Lawrenson , K , Lee , J M , Spindler , T J , Lin , Y G , Pejovic , T , Bean , Y , Li , Q , Coetzee , S , Hazelett , D , Isaccs , C , Hein , A , Ekici , A B , Beckmann , M W , Fasching , P A , Lambrechts , D , Van Nieuwenhuysen , E , Vergote , I , Lambrechts , S , Doherty , J A , Wicklund , K G , Rossing ....
سنة النشر: 2015
المجموعة: The University of Manchester: Research Explorer - Publications
الوصف: Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P <5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1038/ng.3185
الإتاحة: https://doi.org/10.1038/ng.3185Test
https://research.manchester.ac.uk/en/publications/93998625-ab14-4241-91ed-86c5c3f8d1f2Test
حقوق: info:eu-repo/semantics/closedAccess
رقم الانضمام: edsbas.48C6C53E
قاعدة البيانات: BASE