التفاصيل البيبلوغرافية
العنوان:
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
المؤلفون:
Sungnak, W. , Huang, N. , Bécavin, C. , Berg, M. , Queen, R. , Litvinukova, M. , Talavera-López, C. , Maatz, H. , Reichart, D. , Sampaziotis, F. , Worlock, K. B. , Yoshida, M. , Barnes, J. L. , Banovich, N. E. , Barbry, P. , Brazma, A. , Collin, J. , Desai, T. J. , Duong, T. E. , Eickelberg, O. , Falk, C. , Farzan, M. , Glass, I. , Gupta, R. K. , Haniffa, M. , Horvath, P. , Hubner, N. , Hung, D. , Kaminski, N. , Krasnow, M. , Kropski, J. A. , Kuhnemund, M. , Lako, M. , Lee, H. , Leroy, S. , Linnarson, S. , Lundeberg, Joakim , Meyer, K. B. , Miao, Z. , Misharin, A. V. , Nawijn, M. C. , Nikolic, M. Z. , Noseda, M. , Ordovas-Montanes, J. , Oudit, G. Y. , Pe’er, D. , Powell, J. , Quake, S. , Rajagopal, J. , Tata, P. R. , Rawlins, E. L. , Regev, A. , Reyfman, P. A. , Rozenblatt-Rosen, O. , Saeb-Parsy, K. , Samakovlis, Christos , Schiller, H. B. , Schultze, J. L. , Seibold, M. A. , Seidman, C. E. , Seidman, J. G. , Shalek, A. K. , Shepherd, D. , Spence, J. , Spira, A. , Sun, X. , Teichmann, S. A. , Theis, F. J. , Tsankov, A. M. , Vallier, L. , van den Berge, M. , Whitsett, J. , Xavier, R. , Xu, Y. , Zaragosi, L. -E , Zerti, D. , Zhang, H. , Zhang, K. , Rojas, M. , Figueiredo, F. , Network, HCA Lung Biological
المصدر:
Nature Medicine . 26(5):681-687
مصطلحات موضوعية:
angiotensin converting enzyme 2 , atp10b protein , c15orf48 protein , cathepsin B , cathepsin L , cdc42ep5 protein , crym protein , cyp2f1 protein , duoxa2 protein , fam3d protein , fcgbp protein , ido1 protein , lypd2 protein , messenger RNA , mx1 protein , oas1 protein , prkar2b protein , prostate stem cell antigen , protein , protein S 100 , proteinase , rarres1 protein , slc5a8 protein , spdef protein , st3gal4 enzyme , st6gal1 enzyme , tmprss2 protein , ube2l6 protein , unclassified drug , virus enzyme , vitronectin , Article , colon tissue , comparative study , cornea epithelium , cornea tissue , coronavirus disease 2019 , epithelium cell , esophagus tissue , fetus , fetus tissue , gene expression , gene expression level , heart tissue , human , human cell , human tissue , ileum tissue , immune response gene , innate immunity , kidney tissue , liver tissue , marker gene , muscle tissue , nose epithelium , pancreas tissue , priority journal , prostate tissue , retina tissue , Severe acute respiratory syndrome coronavirus 2 , single cell RNA seq , skeletal muscle , spleen tissue , testis tissue , viral tropism , virus entry , virus transmission
الوصف:
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
وصف الملف:
print
الوصول الحر:
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273986Test https://doi.org/10.1038/s41591-020-0868-6Test
قاعدة البيانات:
SwePub
