التفاصيل البيبلوغرافية
| العنوان: |
Glucose Concentration: Implication in Peritoneal Dialysis |
| المؤلفون: |
Human Peritoneal, Mesothelial Cells, Due High Dialysate, Susan Yung, Xiao-rui Chen, Ryan Cw Tsang, Qing Zhang |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://jasn.asnjournals.org/content/15/5/1178.full.pdfTest. |
| المجموعة: |
CiteSeerX |
| الوصف: |
Prolonged exposure of the peritoneal mesothelium to high dialysate glucose concentrations reduces anionic sites that are critical to its selective permeability, thereby impairing the peritoneal transport properties in patients on long-term peritoneal dialysis (PD). Perlecan, an anionic heparan sulfate proteoglycan, is pivotal to the selective permeability of basement membranes, and high glucose concentrations modulate its synthesis in mesangial cells. The effect of glucose on perlecan expression in the peritoneal mesothelium has not been established. We investigated perlecan expression in peritoneal biopsies from patients on PD, and the effect of high glucose concentrations on perlecan synthesis in cultured human peritoneal mesothelial cells (HPMC). Peritoneal biopsies from PD patients showed reduced perlecan expression compared with controls. Exposure of HPMC to high glucose concentrations resulted in a dose-dependent reduction in the synthesis of perlecan polypeptide and its deposition into the extracellular matrix. These effects were mediated in part through the induction of TGF-�1. Characterization studies showed that perlecan synthesized by HPMC contained solely heparan sulfate glycosaminoglycan (HS GAG) chains, and [ 35 S]-incorporation studies demonstrated progressive reduction of their de novo synthesis with increasing glucose concentrations (68142 � |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.4029Test; http://jasn.asnjournals.org/content/15/5/1178.full.pdfTest |
| الإتاحة: |
http://jasn.asnjournals.org/content/15/5/1178.full.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.221122EE |
| قاعدة البيانات: |
BASE |
