نتائج البحث - "Drug Resistance, Neoplasm -- genetics"

1

The EGFR-STYK1-FGF1 axis sustains functional drug tolerance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer

المؤلفون: Carolien Eggermont, Philippe Giron, Maxim Noeparast, Hugo Vandenplas, Pedro Aza-Blanc, Gustavo J. Gutierrez, Jacques De Grève

المساهمون: Laboratory for Medical and Molecular Oncology, Clinical sciences, Faculty of Medicine and Pharmacy, Medical Genetics, Basic (bio-) Medical Sciences, Biology

مصطلحات موضوعية: Cancer Research, Lung Neoplasms, Mutation/genetics, Carcinoma, Non-Small-Cell Lung/drug therapy, Immunology, Drug Resistance, Neoplasm/genetics, Receptor Protein-Tyrosine Kinases/metabolism, Afatinib, Cellular and Molecular Neuroscience, Carcinoma, Non-Small-Cell Lung, Afatinib/pharmacology, ErbB Receptors/antagonists & inhibitors, Humans, Genetics(clinical), RNA, Small Interfering, Lung Neoplasms/drug therapy, Protein Kinase Inhibitors, Drug Tolerance/genetics, RNA, Small Interfering/genetics, Receptor Protein-Tyrosine Kinases, Drug Tolerance, Cell Biology, ErbB Receptors, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, Mutation, oncology, Fibroblast Growth Factor 1, Fibroblast Growth Factor 1/metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8d369e1425569db56d294a0d66c876Test
https://hdl.handle.net/20.500.14017/e1c070ad-96c6-42f6-a7ad-d2c11f334822Test

2

Influence of Concurrent Mutations on Overall Survival in EGFR-mutated Non-small Cell Lung Cancer

المؤلفون: Alfredo Addeo, Alex Friedlaender, Petros Tsantoulis, Mathieu Chevallier

المصدر: Cancer Genomics & Proteomics, Vol. 17, No 5 (2020) pp. 597-603
Cancer Genomics Proteomics

مصطلحات موضوعية: Male, Oncology, Cancer Research, Lung Neoplasms, medicine.medical_treatment, Resistance, DNA Mutational Analysis, NSCLC, medicine.disease_cause, Lung Neoplasms / drug therapy, Biochemistry, Class I Phosphatidylinositol 3-Kinases / genetics, Lung Neoplasms / mortality, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Osimertinib, Epidermal growth factor receptor, Protein Kinase Inhibitors / therapeutic use, Lung, ddc:616, Aged, 80 and over, biology, Carcinoma, Non-Small-Cell Lung / mortality, Drug Resistance, Neoplasm / genetics, PTEN Phosphohydrolase / genetics, Middle Aged, ErbB Receptors / antagonists & inhibitors, Prognosis, Resistance mutation, Co-mutations, Progression-Free Survival, ErbB Receptors, 030220 oncology & carcinogenesis, Proto-Oncogene Proteins p21(ras) / genetics, Female, Carcinoma, Non-Small-Cell Lung / drug therapy, KRAS, ErbB Receptors / genetics, Research Article, Concurrent mutations, medicine.medical_specialty, Class I Phosphatidylinositol 3-Kinases, EGFR, Lung Neoplasms / pathology, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Lung / pathology, Carcinoma, Non-Small-Cell Lung / pathology, Internal medicine, Genetics, medicine, Carcinoma, Non-Small-Cell Lung / genetics, Humans, PTEN, Lung cancer, Protein Kinase Inhibitors, Molecular Biology, Aged, Retrospective Studies, Lung Neoplasms / genetics, Chemotherapy, business.industry, Protein Kinase Inhibitors / pharmacology, PTEN Phosphohydrolase, Retrospective cohort study, medicine.disease, respiratory tract diseases, Drug Resistance, Neoplasm, Mutation, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d312c1999e489861fdf5dde140077Test
https://doi.org/10.21873/cgp.20216Test

3

Molecular pathology of tumors of the central nervous system

المؤلفون: Loudy P Priesterbach-Ackley, Pieter Wesseling, Bjarne Winther Kristensen, Jeanette Krogh Petersen

المصدر: Annals of Oncology, 30(8), 1265. Oxford University Press
Kristensen, B W, Priesterbach-Ackley, L P, Petersen, J K & Wesseling, P 2019, ' Molecular Pathology of Tumors of the Central Nervous System ', Annals of Oncology, vol. 30, no. 8, pp. 1265-1278 . https://doi.org/10.1093/annonc/mdz164Test
Kristensen, B W, Priesterbach-Ackley, L P, Petersen, J K & Wesseling, P 2019, ' Molecular pathology of tumors of the central nervous system ', Annals of Oncology, vol. 30, no. 8, pp. 1265-1278 . https://doi.org/10.1093/annonc/mdz164Test
Annals of Oncology

مصطلحات موضوعية: 0301 basic medicine, Ependymoma, Solitary fibrous tumor, Neoplasms, Germ Cell and Embryonal/diagnosis, 0302 clinical medicine, molecular pathology, glioma, Antineoplastic Combined Chemotherapy Protocols, Molecular Targeted Therapy, Molecular pathology, Brain Neoplasms, Brain, Glioma/diagnosis, Hematology, Neoplasms, Germ Cell and Embryonal, Prognosis, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Survival Rate, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Atypical teratoid rhabdoid tumor, integrated diagnosis, IDH1, embryonal tumor, Reviews, Drug Resistance, Neoplasm/genetics, Antineoplastic Combined Chemotherapy Protocols/pharmacology, medulloblastoma, Biomarkers, Tumor/analysis, 03 medical and health sciences, Glioma, medicine, Biomarkers, Tumor, Journal Article, Humans, Brain/pathology, Hemangiopericytoma, Medulloblastoma, Brain Neoplasms/diagnosis, business.industry, DNA Methylation, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic/drug effects, Mutation, Cancer research, business, Molecular Targeted Therapy/methods, CNS tumor

وصف الملف: text/plain; application/pdf; image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878a37f0fbef4c9facbc0f76ef647cdcTest
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072721345&origin=inwardTest

4

Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

المؤلفون: Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Eickhoff, Nils, Schuurman, Karianne, de Barros, Hilda, Alkemade, Maartje, Bekers, Elise M., Severson, Tesa M., Sanders, Joyce, Huang, Chia Chi Flora, Morova, Tunc, Altintas, Umut Berkay, Hoekman, Liesbeth, Kim, Yongsoo, Baca, Sylvan C., Sjöström, Martin, Zaalberg, Anniek, Hintzen, Dorine C., de Jong, Jeroen, Kluin, Roelof J.C., de Rink, Iris, Giambartolomei, Claudia, Seo, Ji Heui, Pasaniuc, Bogdan, Altelaar, Maarten, Medema, René H., Feng, Felix Y., Zoubeidi, Amina, Freedman, Matthew L., Wessels, Lodewyk F.A., Butler, Lisa M., Lack, Nathan A., van der Poel, Henk, Bergman, Andries M., Zwart, Wilbert, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

المساهمون: Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Chemical Biology, Pathology, CCA - Cancer biology and immunology, Ethics, Law & Medical humanities, APH - Quality of Care, Urology

المصدر: Cancer Discovery, 12(9), 2074-2097. American Association for Cancer Research Inc.
Cancer Discovery, 12(9), 2074. American Association for Cancer Research Inc.
Linder, S, Hoogstraat, M, Stelloo, S, Eickhoff, N, Schuurman, K, de Barros, H, Alkemade, M, Bekers, E M, Severson, T M, Sanders, J, Huang, C-C F, Morova, T, Altintas, U B, Hoekman, L, Kim, Y, Baca, S C, Sjöström, M, Zaalberg, A, Hintzen, D C, de Jong, J, Kluin, R J C, de Rink, I, Giambartolomei, C, Seo, J-H, Pasaniuc, B, Altelaar, M, Medema, R H, Feng, F Y, Zoubeidi, A, Freedman, M L, Wessels, L F A, Butler, L M, Lack, N A, van der Poel, H, Bergman, A M & Zwart, W 2022, ' Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence ', Cancer discovery, vol. 12, no. 9, pp. 2074-2097 . https://doi.org/10.1158/2159-8290.CD-21-0576Test
Cancer Discov
Cancer discovery, 12(9)
Cancer discovery, vol 12, iss 9
Cancer discovery, 12(9), 2074-2097. American Association for Cancer Research Inc.

مصطلحات موضوعية: Urologic Diseases, Epigenomics, Male, Aging, Oncology and Carcinogenesis, ARNTL Transcription Factors/genetics, Drug Resistance, Drug Resistance, Neoplasm/genetics, SDG 3 – Goede gezondheid en welzijn, Castration-Resistant, Article, Cell Line, Androgen, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Receptors, Nitriles, Phenylthiohydantoin, Taverne, 2.1 Biological and endogenous factors, Humans, Aetiology, Androgens/pharmacology, Cancer, Prostatic Neoplasms, Castration-Resistant/drug therapy, Castration-Resistant/drug therapy, Tumor, Nitriles/therapeutic use, Neoplasm/genetics, Prostate Cancer, Aryl Hydrocarbon Receptor Nuclear Translocator, Androgen/genetics, Prostatic Neoplasms, ARNTL Transcription Factors, Receptors, Androgen/genetics, Circadian Rhythm, Prostatic Neoplasms, Castration-Resistant, Oncology, 5.1 Pharmaceuticals, Drug Resistance, Neoplasm, Receptors, Androgen, Benzamides, Androgens, Neoplasm, Development of treatments and therapeutic interventions, Biotechnology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039c32e9b5e18899785f8d02a47ca186Test
https://doi.org/10.1158/2159-8290.cd-21-0576Test

5

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

المساهمون: Rueda, Oscar M [0000-0003-0008-4884], Giovannetti, Agnese [0000-0001-5207-7243], Chin, Suet-Feung [0000-0001-5697-1082], Carnevalli, Larissa S [0000-0001-7432-0195], Provenzano, Elena [0000-0003-3345-3965], Serra, Violeta [0000-0001-6620-1065], Bressan, Dario [0000-0003-3592-699X], Mills, Gordon B [0000-0002-0144-9614], Ali, H Raza [0000-0001-7587-0906], Caldas, Carlos [0000-0003-3547-1489], Apollo - University of Cambridge Repository, IMAXT Consortium, Ali, H.R., Al Sa'd, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E.S., Bressan, D., Bruna, A., Burger, M., Caldas, C., Callari, M., Cannell, I.G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E.A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G.J., Harris, O., Harris, S., Jauset, C., Joyce, J.A., Karagiannis, E.D., Kovačević, T., Kuett, L., Kunes, R., Küpcü, Y.A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C.M., Nugent, F., O'Flanagan, C.H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A.J., Rueda, O.M., Ruiz, T., Sawicka, K., Sepúlveda, L.A., Shah, S.P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S.L., Walton, N.A., Wassie, A.T., Watson, S.S., Weselak, J., Wild, S.A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., Zhuang, X.

المصدر: Nature Communications
Nature communications, vol. 12, no. 1, pp. 1998
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Science, Tumour heterogeneity, Morpholines, Cell, General Physics and Astronomy, Breast Neoplasms, Drug resistance, Mice, SCID, Biology, Animals, Benzamides/pharmacology, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Cell Line, Tumor, Drug Resistance, Neoplasm/drug effects, Drug Resistance, Neoplasm/genetics, Female, Heterografts/drug effects, Heterografts/metabolism, Humans, MCF-7 Cells, Mice, Inbred NOD, Mice, Knockout, Morpholines/pharmacology, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Pyrimidines/pharmacology, Treatment Outcome, Xenograft Model Antitumor Assays/methods, General Biochemistry, Genetics and Molecular Biology, Article, Piperazines, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, Mass cytometry, Protein Kinase Inhibitors, Multidisciplinary, Genetic heterogeneity, Cancer, General Chemistry, medicine.disease, Biobank, Phenotype, Xenograft Model Antitumor Assays, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Pyrimidines, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Benzamides, Cancer research, Heterografts

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0712127e8562959156b1ae7983d647fTest

6

Bayesian Pathway Analysis for Complex Interactions

المؤلفون: Per Damkier, Anders Kjærsgaard, Thomas P. Ahern, Timothy L. Lash, Stephen Hamilton-Dutoit, James W. Baurley, Lindsay J Collin, Deirdre Cronin-Fenton, Michael E. Zwick

المصدر: Baurley, J W, Kjærsgaard, A, Zwick, M E, Cronin-Fenton, D P, Collin, L J, Damkier, P, Hamilton-Dutoit, S, Lash, T L & Ahern, T P 2020, ' Bayesian Pathway Analysis for Complex Interactions ', American Journal of Epidemiology, vol. 189, no. 12, pp. 1610-1622 . https://doi.org/10.1093/aje/kwaa130Test
Am J Epidemiol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef97ce2ec28500db579faf4d0677c11Test
https://pure.au.dk/portal/da/publications/bayesian-pathway-analysis-for-complex-interactionsTest(52ce96a9-89c8-4cfd-9914-087ae3645a90).html

7

Advanced technological tools to study multidrug resistance in cancer

المؤلفون: Yehuda G. Assaraf, Luca Andrei, Mónica Suárez Korsnes, Radka Vaclavikova, Ignacio Ochoa Garrido, Tijana Stanković, Sandor Kasas, Milica Pešić

المصدر: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Drug Resistance Updates
Drug resistance updates, vol. 48, pp. 100658
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Cancer Research, Cell Culture Techniques, Drug resistance, Microscopy, Atomic Force, stem-cells, Transcriptome, Atomic force microscopy, drug-resistance, 0302 clinical medicine, Neoplasms, Tumor Microenvironment, Medicine, Pharmacology (medical), cancer multidrug resistance, microfluidic devices, Cancer multidrug resistance, atomic force microscopy, single live-cell tracking, High-Throughput Nucleotide Sequencing, personalized medicine, tumor-cells, circular rnas, Drug Resistance, Multiple, 3. Good health, Infectious Diseases, Oncology, 030220 oncology & carcinogenesis, extracellular vesicles, Biotechnology, Microfluidic devices, Computational biology, 03 medical and health sciences, Animals, Humans, atomic-force microscopy, Epigenetics, breast-cancer, Pharmacology, Tumor microenvironment, 3D cultures, business.industry, Cancer, single-cell tracking, medicine.disease, Multiple drug resistance, 030104 developmental biology, Biotechnology/methods, Cell Culture Techniques/methods, Drug Resistance, Multiple/genetics, Drug Resistance, Neoplasm/genetics, High-Throughput Nucleotide Sequencing/methods, Microscopy, Atomic Force/methods, Neoplasms/genetics, Neoplasms/pathology, Tumor Microenvironment/genetics, Next-generation sequencing, Single live-cell tracking, a-chip platforms, Drug Resistance, Neoplasm, Cancer cell, next-generation sequencing, business, 3d cultures

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f964cac0c4545e6fbfbd29e9725476ccTest
http://zaguan.unizar.es/record/95733Test

8

دورية أكاديمية

Effect of siRNAs targeting the EGFR T790M mutation in a non-small cell lung cancer cell line resistant to EGFR tyrosine kinase inhibitors and combination with various agents.

المؤلفون: Chen, Gang, Kronenberger, Peter, Teugels, Erik, Umelo, Ijeoma, De Greve, Jacques

المصدر: Biochemical and Biophysical Research Communications, 431 (3), 623-9 (2013)

مصطلحات موضوعية: Antibodies, Monoclonal, Humanized/pharmacology, Antineoplastic Agents/pharmacology, Carcinoma, Non-Small-Cell Lung/enzymology, Cell Line, Tumor, Cetuximab, Drug Resistance, Neoplasm/genetics, Gene Targeting, Humans, Lung Neoplasms/enzymology, Mutation, Protein Kinase Inhibitors/pharmacology, Quinazolines/pharmacology, RNA, Small Interfering/genetics, Receptor, Epidermal Growth Factor/antagonists & inhibitors/genetics, Human health sciences, Oncology, Sciences de la santé humaine, Oncologie

العلاقة: urn:issn:0006-291X; urn:issn:1090-2104

الوصول الحر: https://orbi.uliege.be/handle/2268/197879Test

View record in ORBi

9

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models

المؤلفون: Zheng Xue, Tonći Šuštić, René Bernards, Oscar M. Rueda, Daniel J. Vis, Alejandra Bruna, Sake van Wageningen, Ankita Sati Batra, Carlos Caldas, Evert Bosdriesz, Lodewyk F. A. Wessels

المساهمون: Bosdriesz, Evert [0000-0002-8788-9548], Bernards, René [0000-0001-8677-3423], Apollo - University of Cambridge Repository, Bioinformatics

المصدر: Xue, Z, Vis, D J, Bruna, A, Sustic, T, van Wageningen, S, Batra, A S, Rueda, O M, Bosdriesz, E, Caldas, C, Wessels, L F A & Bernards, R 2018, ' MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models ', Cell Research, vol. 28, no. 7, pp. 719-729 . https://doi.org/10.1038/s41422-018-0044-4Test
Cell Research
Cell Research, 28(7), 719-729. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, MAP Kinase Kinase 4, Nude, Drug Resistance, MAP2K4, Mitogen-activated protein kinase kinase, medicine.disease_cause, Receptor tyrosine kinase, Mice, Colonic Neoplasms/drug therapy, Loss of Function Mutation, MAP Kinase Kinase 4/antagonists & inhibitors, Inbred BALB C, Mutation, Mice, Inbred BALB C, Benzimidazoles/pharmacology, Tumor, Kinase, Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors, Colonic Neoplasms, Heterografts, Female, Prostatic Neoplasms/drug therapy, MAP Kinase Signaling System, MAP Kinase Kinase Kinase 1, Mice, Nude, Breast Neoplasms, Drug Resistance, Neoplasm/genetics, Biology, Article, Cell Line, 03 medical and health sciences, Breast Neoplasms/drug therapy, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Animals, Humans, MAP Kinase Kinase Kinase 1/antagonists & inhibitors, Protein kinase A, Molecular Biology, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Signaling System/drug effects, Neoplasm/genetics, Cancer, Prostatic Neoplasms, Cell Biology, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, Cancer research, biology.protein, Benzimidazoles

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ac8605c40f79c5eb054b8c12b0a93bTest
https://doi.org/10.1038/s41422-018-0044-4Test

10

دورية أكاديمية

P-glycoprotein - a pump of significance for drug response / P-glykoprotein - en pumpe av betydning for legemiddelrespons

المؤلفون: Molden, E

المصدر: Tidsskrift for Den Norske Laegeforening. 124(22):2921

View record in SveMed+

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