التفاصيل البيبلوغرافية
| العنوان: |
The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions |
| المؤلفون: |
Doyuran, Damla Zeynep, Eronat, Ömer |
| المساهمون: |
Gaziantep Üniversitesi |
| المصدر: |
The International Journal of Biological Markers ; volume 38, issue 3-4, page 233-242 ; ISSN 0393-6155 1724-6008 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Cancer Research, Clinical Biochemistry, Oncology, Pathology and Forensic Medicine |
| الوصف: |
Introduction Papillary thyroid carcinoma is the most common malignancy of the endocrine system. Most papillary thyroid carcinoma patients enjoy excellent outcomes. However, in patients with biologically aggressive features, additional prognostic and predictive data may aid disease management. Dysregulation of the endocannabinoid system including the cannabinoid receptors 1 and 2 (CB-1R and CB-2R) during carcinogenesis has been extensively studied over the last few decades. The aim of this study was to evaluate immunohistochemically the expression levels of both receptors in patients with papillary thyroid carcinoma and benign diseases, and to compare these rates and the histopathologically and clinically prognostic features. Methods The pathological materials and clinical data of 100 patients with papillary thyroid carcinoma and 40 with benign diseases were retrospectively re-evaluated. All tissues were immunohistochemically stained for CB-1R and CB-2R. The expression levels of CB-1R and CB-2R in papillary thyroid carcinomas, and benign lesions were recorded and compared with the pathological and clinical features. Results The expression levels of both receptors were significantly higher in papillary thyroid carcinoma patients than in those with benign conditions ( P = 0.001). CB-1R expression correlated with both extrathyroidal extension ( P = 0.022) and capsular invasion ( P = 0.001). CB-2R expression was associated with the risk group of the American Thyroid Association stratification system ( P = 0.004). Conclusion Our study suggests that increased cannabinoid receptor expression contributes to thyroid carcinogenesis. The CB-2R expression level could provide additional information aiding risk management. Furthermore, the CB-1R and CB-2R antibodies might increase the accuracy of papillary thyroid carcinoma diagnosis when combined with the papillary thyroid carcinoma biomarkers assayed after fine-needle aspiration of neoplastic cells. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/03936155231200285 |
| الإتاحة: |
https://doi.org/10.1177/03936155231200285Test |
| حقوق: |
https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.E6622B8 |
| قاعدة البيانات: |
BASE |
