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1دورية أكاديمية
المؤلفون: Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, Marta Popović, John Fielden, Bruno Vaz, Judith Oehler, Domenic Pilger, Davor Lessel, Katherine Wiseman, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Melanie Philipp, Kristijan Ramadan
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2041-1723Test
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2دورية أكاديمية
المؤلفون: Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2041-1723Test
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3دورية أكاديمية
المؤلفون: André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan, Thorsten Hoppe
المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2041-1723Test
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4دورية أكاديمية
المؤلفون: André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan, Thorsten Hoppe
المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2041-1723Test
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المؤلفون: Kunzah Jamal, Anna Staniszewska, Jacob Gordon, Domenic Pilger, Giuditta Illuzzi, Joanne Wilson, Aaron Smith, Eric Gosselin, Lisa McWilliams, Shenghua Wen, Frank McGrath, Gregory Dowdell, Dominic Kabbabe, Matthew Griffin, Barry Davies, Petra Hamerlik, Magnus Schou, Andy Pike, Jeffrey Johannes
المصدر: Neuro-Oncology. 24:vii98-vii98
مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d8a5ab0fd6bf02e246aaefc2c86f1258Test
https://doi.org/10.1093/neuonc/noac209.366Test -
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المؤلفون: Stephen P. Jackson, Leonard W. Seymour, Domenic Pilger
المساهمون: Pilger, Domenic [0000-0001-7339-0685], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository
المصدر: Genes Dev
مصطلحات موضوعية: PD-L1, DNA Repair, DNA damage, DNA repair, medicine.medical_treatment, Poly ADP ribose polymerase, Review, Biology, Adaptive Immunity, Poly(ADP-ribose) Polymerase Inhibitors, DNA damage response, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Cancer immunotherapy, Neoplasms, PD-1, Genetics, medicine, Humans, PARP inhibitors, Discoidin Domain Receptors, Immune Checkpoint Inhibitors, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Immunity, Cellular, Immunotherapy, body regions, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, DNA, Developmental Biology, STING, cGAS, DNA Damage
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4e97ec8cd5b53d98bd6bc8b3facc68Test
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المؤلفون: Emilio Lecona, Patricia Ubieto-Capella, André Franz, Domenic Pilger, Thorsten Hoppe, Antonio Galarreta, Fabian den Brave, Pablo Valledor, Guillermo de la Vega-Barranco, Alejandro Fernández-Llorente, Vanesa Lafarga, Oscar Fernandez-Capetillo
المصدر: Cell Reports
مصطلحات موضوعية: DNA Replication, ATPase, DUB, Article, General Biochemistry, Genetics and Molecular Biology, Cofactor, Animals, Genetically Modified, Evolution, Molecular, Ubiquitin-Specific Peptidase 7, Ubiquitin, Valosin Containing Protein, ubiquitin, Endopeptidases, Animals, Humans, UBXN-3, Caenorhabditis elegans, Caenorhabditis elegans Proteins, FAF1, Adaptor Proteins, Signal Transducing, MATH-33, biology, DNA synthesis, Chemistry, Ubiquitination, DNA replication, Sumoylation, HCT116 Cells, DNA Replication Fork, biology.organism_classification, Chromatin, Cell biology, CDC-48, SUMO, USP7, MCF-7 Cells, biology.protein, Apoptosis Regulatory Proteins, Carrier Proteins, VCP, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a291217615ce3cb75fbfeedec0a8f0a2Test
https://doi.org/10.1016/j.celrep.2021.109819Test -
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المؤلفون: Katherine Wiseman, Martin D. Burkhalter, Abhay Narayan Singh, Ignacio Torrecilla, Melanie Philipp, John Fielden, Marta Popović, Domenic Pilger, Davor Lessel, Kristijan Ramadan, Iolanda Vendrell, Swagata Halder, Roman Fischer, Bruno Vaz, Judith Oehler
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)مصطلحات موضوعية: 0301 basic medicine, Genome instability, medicine.medical_treatment, General Physics and Astronomy, 02 engineering and technology, environment and public health, chemistry.chemical_compound, 0302 clinical medicine, Phosphorylation, lcsh:Science, Zebrafish, Metalloproteinase, 0303 health sciences, Multidisciplinary, Biochemistry and Molecular Biology, 021001 nanoscience & nanotechnology, Chromatin, Cell biology, DNA-Binding Proteins, 030220 oncology & carcinogenesis, embryonic structures, Signal transduction, biological phenomena, cell phenomena, and immunity, 0210 nano-technology, Signal Transduction, DNA Replication, animal structures, Science, SPRTN, Chk1, DNA replication, DNA-protein crosslinks, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Genomic Instability, Article, 03 medical and health sciences, medicine, Animals, CHEK1, Kinase activity, 030304 developmental biology, Protease, Models, Genetic, DNA Breaks, Basic Medical Sciences, General Chemistry, DNA Replication Fork, enzymes and coenzymes (carbohydrates), 030104 developmental biology, chemistry, Checkpoint Kinase 1, Proteolysis, lcsh:Q, Replisome, DNA
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a27bf3c6bc52b0a15e3a055a5fb3bbTest
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المؤلفون: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu
المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)
المصدر: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4Test
https://www.repository.cam.ac.uk/handle/1810/282947Test -
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المؤلفون: Stephen P. Jackson, Matylda Sczaniecka-Clift, Domenic Pilger, Mukerrem Demir, Michael Woods, Petra Beli, Josep V. Forment, Kosuke Yusa, Stephen T. Durant, Julia Coates, Hannes Ponstingl, Elisabeth Chen, Anna Barros, Matthias Ostermaier, Beiyuan Fu, Gabriel Balmus, Allan Bradley, Fengtang Yang, Francisco Munoz Martinez, Tatjana Stankovic, Mareike Herzog, Emmanouil Metzakopian, David J. Adams, Yaron Galanty
المساهمون: Balmus, Gabriel [0000-0003-2872-4468], Pilger, Domenic [0000-0001-7339-0685], Yang, Fengtang [0000-0002-3573-2354], Chen, Elisabeth [0000-0003-2129-7985], Ponstingl, Hannes [0000-0001-7573-1703], Durant, Stephen T [0000-0003-4209-7499], Galanty, Yaron [0000-0001-7167-9004], Beli, Petra [0000-0001-9507-9820], Forment, Josep V [0000-0002-7797-2583], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)مصطلحات موضوعية: DNA End-Joining Repair, endocrine system diseases, Ataxia Telangiectasia Mutated Proteins, Piperazines, law.invention, chemistry.chemical_compound, DNA Ligase ATP, Mice, 0302 clinical medicine, law, Mice, Inbred NOD, DNA Breaks, Double-Stranded, lcsh:Science, chemistry.chemical_classification, Mice, Knockout, 0303 health sciences, biology, BRCA1 Protein, Mouse Embryonic Stem Cells, 3. Good health, Non-homologous end joining, 030220 oncology & carcinogenesis, Female, medicine.drug, DNA Replication, DNA damage, Cell Survival, Science, Antineoplastic Agents, Article, Olaparib, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, 030304 developmental biology, DNA ligase, Topoisomerase, Neoplasms, Experimental, chemistry, Drug Resistance, Neoplasm, Mutation, biology.protein, Cancer research, Suppressor, Phthalazines, lcsh:Q, Topotecan, CRISPR-Cas Systems, Homologous recombination
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdf76caefb39985120b8937ddce2cb2Test