Are psychiatric disorders associated with thyroid hormone therapy in adolescents and young adults with type 1 diabetes?
| العنوان: | Are psychiatric disorders associated with thyroid hormone therapy in adolescents and young adults with type 1 diabetes? |
|---|---|
| المؤلفون: | Dirk Bierkamp-Christophersen, Melanie Hess, Angela Galler, Elke Hammer, Angeliki Pappa, Martin Holder, Alexander J. Eckert, Stefanie Lanzinger, Carsten Döing, Matthias Papsch |
| بيانات النشر: | Universität Ulm, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Thyroiditis, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Kind, CHILDREN, 030204 cardiovascular system & hematology, Mental disorders, Anxiety, 0302 clinical medicine, Diabetes mellitus, Type 1, Germany, Medicine, Child, Depression (differential diagnoses), biology, Depression, Thyroid disease, Mental Disorders, Thyroid, AUTOIMMUNE-THYROIDITIS, Diabetes mellitus Typ 1, Prognosis, PREVALENCE, Aufmerksamkeitsdefizit-Syndrom, medicine.anatomical_structure, Hypothyreose, DEPRESSIVE SYMPTOMS, Female, medicine.drug, Adult, medicine.medical_specialty, Thyroid Hormones, Adolescent, Levothyroxine, 030209 endocrinology & metabolism, psychiatric disorder, 03 medical and health sciences, Young Adult, Hypothyroidism, Thyroid peroxidase, Humans, ddc:610, Psychiatry, Type 1 diabetes, business.industry, Odds ratio, medicine.disease, Thyroid Diseases, Diabetes Mellitus, Type 1, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, biology.protein, Thyroglobulin, business, DDC 610 / Medicine & health, Follow-Up Studies |
| الوصف: | Background To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention���deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11���25 years). Methods We compared 9368 type 1 diabetes patients with thyroid autoimmunity (3789 of them treated with levothyroxine) with 62 438 type 1 diabetes patients without any thyroid disease from a multicentre diabetes patient follow���up registry (DPV) in terms of psychiatric disorders. Thyroid autoimmunity was defined as documented diagnosis of Hashimoto thyroiditis or positive antibodies against thyroid peroxidase or thyroglobulin. Multivariable logistic regression models were used to calculate odds ratios for the respective psychiatric disorders in type 1 diabetes patients with thyroid autoimmunity (overall and stratified by levothyroxine therapy) compared to type 1 diabetes patients without thyroid diseases (reference). Results Of the 9368 patients with thyroid autoimmunity, 62% were female with a median (Q1���Q3) age of 16.3 (14.2���17.6) years. Thyroid autoimmunity (with or without levothyroxine therapy) revealed a slight, but significant higher chance for depression (odds ratio [OR], 1.35, 95% confidence interval [CI], 1.19, 1.52), eating disorder (OR, 1.25, CI, 1.03, 1.51), attention���deficit/hyperactivity disorder (OR, 1.22, CI, 1.07, 1.39) and schizophrenia (OR, 1.63, CI, 1.04, 2.56). In individuals with prescribed levothyroxine therapy because of thyroid dysfunction significantly higher odds for depression (OR, 1.63, CI, 1.34, 1.99), anxiety (OR, 1.60, CI, 1.18, 2.18), and attention���deficit/hyperactivity disorder (OR, 1.71, CI, 1.38, 2.12) were observed compared to reference. Thyroid autoimmunity without required levothyroxine therapy revealed no differences to the reference group. Conclusions Patients on levothyroxine had significantly higher odds for psychiatric disorders, but thyroid autoimmunity in terms of high antibody levels only did not show higher odds for any psychiatric disorder. �� In Copyright http://rightsstatements.org/vocab/InC/1.0Test/ Highlights Several psychiatric disorders were associated with levothyroxine therapy (LT4). Depression, anxiety disorders, and attention���deficit/hyperactivity disorder showed the strongest relation to LT4. Thyroid autoimmunity itself (no LT4) was not associated with psychiatric disorders. image publishedVersion |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13f1f43bcc924885ce5f1ee79742aeaTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b13f1f43bcc924885ce5f1ee79742aea |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |